A5115600953- Long-Term Effects of COVID-19
- Infectious Encephalopathies and Encephalitis
- COVID-19 Clinical Research Studies
- Dermatological and Skeletal Disorders
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Ocular Diseases and Behçet’s Syndrome
- Olfactory and Sensory Function Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- SARS-CoV-2 and COVID-19 Research
- Venous Thromboembolism Diagnosis and Management
- Dysphagia Assessment and Management
- Platelet Disorders and Treatments
- Caveolin-1 and cellular processes
- Infectious Diseases and Mycology
- Fungal Infections and Studies
- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Sarcoidosis and Beryllium Toxicity Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Peripheral Nerve Disorders
- Tracheal and airway disorders
- Cerebrospinal fluid and hydrocephalus
University of Padua
2023-2025
Ospedale Papa Giovanni XXIII
2020-2024
San Raffaele University of Rome
2021
Vita-Salute San Raffaele University
2018-2020
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2020
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2020
Objectives To assess the safety and efficacy of interleukin (IL)−6 blockade with sarilumab in patients severe COVID-19 pneumonia systemic hyperinflammation. Methods We conducted an open-label study (PaO 2 /FiO <300 mm Hg) hyperinflammation (elevated inflammatory markers serum IL-6 levels). Sarilumab 400 mg was administered intravenously addition to standard care results were compared contemporary matched treated alone. Clinical improvement, mortality, predictors response assessed at 28...
COVID-19 neurological manifestations have been progressively recognized. Among available MRI techniques, diffusion weighted imaging (DWI) shows promise to study microstructure, inflammation, and edema. Previous DWI studies reported alterations in brain diffusivity patients, as assessed by morphologic evaluation of scans only. The aim this was assess quantify patients with manifestations. 215 (olfactory and/or other disorders) 36 normal controls were compared studied T1-weighted scans....
The COVID-19 pandemic has affected millions worldwide, causing mortality and multi-organ morbidity. Neurological complications have been recognized. This study aimed to assess brain structural, microstructural, connectivity alterations in patients with COVID-19-related olfactory or cognitive impairment using post-acute (time from onset: 264[208-313] days) multi-directional diffusion-weighted MRI (DW-MRI).
It is increasingly acknowledged that Coronavirus Disease 2019 (COVID-19) can have neurological manifestations, and cerebral microbleeds (CMBs) been observed in this setting. The aim of study was to characterize CMBs patterns on susceptibility-weighted imaging (SWI) hospitalized patients with COVID-19 manifestations. volume quantified correlated clinical laboratory parameters. included who were due COVID-19, exhibited underwent a brain MRI between March May 2020. Neurological, clinical,...
This study aimed at quantifying brain diffusion alterations on DWI scans in 215 COVID-19 patients with neurological manifestations as compared 36 normal controls. The Apparent Diffusion Coefficient (ADC) was quantified tissues and regions, using an in-house MRI processing procedure. In patients, a widespread significant increase ADC found white matter. values were significantly correlated time from disease onset. alteration highest hospitalized patients. Patients disorders showed higher than...
Cardiac amyloidosis is a group of diseases characterized by the deposition amyloid fibers in cardiac tissue. Two forms are mainly reported: light chain (AL) and transthyretin (ATTR) amyloidosis. Among complications there thrombotic events and, to lesser extent, hemorrhagic events. The latter likely caused perivascular resulting capillary fragility, addition INR lability during anticoagulant therapy. onset may be high prevalence atrial fibrillation (AF), mechanical dysfunction myopathy...
Abstract Objective The aim of this study was to assess COVID‐19‐related gray matter (GM) structural alterations in two distinct groups patients presenting with the prevailing and distinctive neurological symptoms – isolated olfactory disorders as sole manifestation (COVID‐OD) cognitive (COVID‐CD) compared a control group unaffected individuals. Methods included 61 COVID‐CD (57 [60–63] years, 62% females), 84 COVID‐OD (49 [35–57] 60% 17 controls (51 [41–52] 41% females). Region‐based...
To determine the incidence of acute neuroimaging (NI) findings and comorbidities in coronavirus disease 2019 (COVID-19)-infected subjects seven U.S. four European hospitals.This is a retrospective study COVID-19-positive with following inclusion criteria: age >18, lab-confirmed COVID-19 infection, NI (NI+) attributed to on CT or MRI brain. NI+ total hospitalized (TN) were assessed.A 37,950 reviewed 4342 underwent NI. was 10.1% (442/4342) including 7.9% (294/3701) United States 22.8%...
Purpose Creating an effective MRI protocol for examining the brachial plexus poses significant challenges, and despite abundance of protocols in literature, there is a lack reference standards basic sequences essential parameters needed replication. The aim this study to establish reproducible 1.5 T imaging protocol, including patient positioning, coil selection, planes, sequence parameters. Methods We systematically investigated sequences, testing each parameter through vivo experiments,...
Abstract Objectives: Neurological manifestations of COVID-19 disease are being increasingly recognized. A growing number studies has been showing CNS abnormalities on brain imaging.Purpose is to describe imaging findings a population patients with neurological and peculiar susceptibility weighted (SWI) sequences. Methods: we retrospectively evaluated data from 50 affected by SARS-CoV-2 infection, who underwent MRI because symptoms between March June 2020.We focused those presenting SWI...