A5101401831- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Spinal Dysraphism and Malformations
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Cerebral Palsy and Movement Disorders
- Acute Ischemic Stroke Management
- Spinal Cord Injury Research
- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Medical Imaging and Analysis
- EEG and Brain-Computer Interfaces
- Moyamoya disease diagnosis and treatment
- Tensor decomposition and applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Neonatal and fetal brain pathology
- Intracranial Aneurysms: Treatment and Complications
- Stroke Rehabilitation and Recovery
- Meningioma and schwannoma management
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury Research
- Fetal and Pediatric Neurological Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Neurosurgical Procedures and Complications
Thomas Jefferson University
2015-2025
Imaging Center
2006-2025
Health and Education Research Management and Epidemiologic Services (United States)
2023
Thomas Jefferson University Hospital
2023
Johns Hopkins University
2017-2020
Foothills Medical Centre
2018
The Royal Melbourne Hospital
2017-2018
University Hospital and Clinics
2018
University Medical Center
2018
Inserm
2018
Poly(A)-RNA enriched for type I procollagen sequences was isolated from normal human fibroblasts and used as template to synthesize double-stranded cDNA with avian myeloblastosis virus (AMV) reverse transcriptase. After the ends had been blunted nuclease S1 dGMP tails added terminal deoxynucleotidyltransferase, annealed pBR322 DNA that previously cleaved EcoRI, AMV transcriptase, dCMP-tailed deoxynucleotidyltransferase. The chimeric molecule transform Escherichia coli strain HB101....
Functional MR imaging is increasingly being used for presurgical language assessment in the treatment of patients with brain tumors, epilepsy, vascular malformations, and other conditions. The inherent complexity fMRI, which includes numerous processing steps selective analyses, compounded by institution-unique approaches to patient training, paradigm choice, an eclectic array postprocessing options from various vendors. Consequently, institutions perform fMRI such markedly different manners...
PURPOSE: To determine the rate and clinical outcome of discrepancies in interpretation by radiology residents staff neuroradiologists posttraumatic cranial computed tomographic (CT) scans. MATERIALS AND METHODS: Prospective evaluation was performed for 419 consecutive emergency CT studies that had been interpreted on call over a 16-month period. Discrepancies between interpretations made those radiologists were divided into two groups: failure to recognize an abnormality (false-negative...
This study presents automated atlas-based magnetization transfer (MT) measurements of the typically developing pediatric cervical spinal cord (SC). We report normative MT ratio (MTR) values from whole white matter (WM) and WM tracts, examining variations with age, sex, height, weight. scans 33 healthy females (mean age = 12.8) 22 males 13.09) were acquired SC (C2-C7) using a 3.0 T MRI. Data processed Toolbox, segmented, registered to PAM50 template. Affine non-rigid transformations...
INTRODUCTION: Glioma-induced brain network reorganization often leads to neurological deficits, which vary depending on tumor location. METHODS: Resting-state fMRI was conducted 32 patients, including 15 with left temporal lesions and 17 frontal glioma. Group independent component analysis (ICA) employed extract networks, excluding tumor-affected areas, followed by dFC using the sliding window method k-means clustering. A two-sample t-test compared between speech-deficit normal speech...
A lumbar hernia usually involves protrusion of extraperitoneal fat or bowel through an area weakness in the posterolateral abdominal wall bounded superiorly by 12th rib, inferiorly iliac crest, posteriorly erector spinae muscle, and anteriorly posterior border external oblique muscle. Most are due to acquired nontraumatic congenital cause. Acute blunt trauma is a rare cause hernia; our knowledge, CT diagnosis this variety has not been reported. Since 1985, approximately 850 patients have...
<h3>BACKGROUND AND PURPOSE:</h3> Recent studies suggest that pediatric subjects as old 8-years-of-age may have difficulty with the ISNCSCI examinations. Our aim was to investigate DTI parameters of healthy spinal cord in children noncervical IS for comparison SCI and prospectively evaluate reliability measures correlate obtained ISNCSCI. <h3>MATERIALS METHODS:</h3> Five controls thoracic lumbar 5 cervical were imaged twice by using a single-shot echo-planar diffusion-weighted sequence. Axial...
PURPOSE: To determine if the cerebral cortical vain sign seen on magnetic resonance (MR) images can be used with color Doppler ultrasound (US) to differentiate enlarged subarachnoid space from subdural collection. MATERIALS AND METHODS: Eighteen infants pericerebral fluid collection were prospectively examined US and MR imaging. Patients classified into two groups: group A, positive vein (visualization of color-coded veins that cross collections at convexities); B, without sign. RESULTS:...
In Brief Study Design. The design was a nonexperimental, repeated measures design. Objective. To examine the reliability of diffusion tensor imaging (DTI) values pediatric cord and to compare DTI with obtained on clinical examination findings from conventional magnetic resonance (MRI). Summary Background Data. quantifies water molecules in directions parallel transverse plane neuronal axons. unique characteristic architecture spinal allows white matter potentially separate gray assess...
<h3>BACKGROUND AND PURPOSE:</h3> DTI in the brain has been well established, but its application spinal cord, especially pediatrics, poses several challenges. The small cord size inherent low SNR of diffusion signal intensity, respiratory and cardiac movements induce artifacts, EPI sequences used for obtaining indices cause eddy-current distortions. purpose this study was to 1) evaluate accuracy cervical children using a newly developed iFOV sequence with spatially selective 2D-RF...
<h3>BACKGROUND AND PURPOSE:</h3> DTI data of the normal healthy spinal cord in children are limited compared with adults and typically focused on cervical cord. The purpose this study was following: to investigate feasibility obtaining repeatable parameters along entire thoracic as a function age developing pediatric subjects; analyze among different transverse levels cord; examine sex differences <h3>MATERIALS METHODS:</h3> Twenty-two subjects underwent 2 identical scans by using 3T MR...
Anticholinergic medications are commonly used to treat urinary urgency and frequency. Muscarinic receptors located in areas beyond the detrusor muscle. In this study we measured changes central nervous system activity patients with lower tract symptoms treated tolterodine or a placebo.A total of 20 female frequency were randomized 4 weeks treatment placebo. Functional magnetic resonance imaging based on blood oxygenation level dependant brain during bladder filling was performed before after...
There are no studies to date,describing changes in the diffusion tensor imaging (DTI) metrics of white matter (WM) regions entire cervical and thoracic spinal cord (SC) remote from lesion pediatric injury (SCI) subjects. The purpose this study was determine whether DTI at sites cephalad caudal a provides measures abnormalities children with chronic SCI. A retrospective included 10 typically developing subjects (TD) SCI who underwent SC 2014–2017. Axial images using an inner field view...
Magnetic resonance based diffusion imaging has been gaining more utility and clinical relevance over the past decade. Using conventional echo planar techniques, it is possible to acquire characterize water within central nervous system (CNS); namely in form of Diffusion Weighted Imaging (DWI) Tensor (DTI). While each modality provides valuable information terms presence its directionality, both techniques are limited assuming an ideal Gaussian distribution for displacement with no...
This is a case report of central nervous system toxicity associated with paradichlorobenzene (PDCB) ingestion. The patient had ingested mothballs composed 99.99% PDCB for period 7 months. She was admitted depression and no neurologic symptoms. Later she developed an acute cerebellar syndrome followed by stupor coma. An extensive workup negative except decreasing levels in her serum. Imaging revealed diffuse leukoencephalopathy. Her clinical picture attributed to toxicity.