A5007896170- Long-Term Effects of COVID-19
- Advanced Neuroimaging Techniques and Applications
- Infectious Encephalopathies and Encephalitis
- Multiple Sclerosis Research Studies
Mario Negri Institute for Pharmacological Research
2023-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2024
The COVID-19 pandemic has affected millions worldwide, causing mortality and multi-organ morbidity. Neurological complications have been recognized. This study aimed to assess brain structural, microstructural, connectivity alterations in patients with COVID-19-related olfactory or cognitive impairment using post-acute (time from onset: 264[208-313] days) multi-directional diffusion-weighted MRI (DW-MRI).
COVID-19 neurological manifestations have been progressively recognized. Among available MRI techniques, diffusion weighted imaging (DWI) shows promise to study microstructure, inflammation, and edema. Previous DWI studies reported alterations in brain diffusivity patients, as assessed by morphologic evaluation of scans only. The aim this was assess quantify patients with manifestations. 215 (olfactory and/or other disorders) 36 normal controls were compared studied T1-weighted scans....
This study aimed at quantifying brain diffusion alterations on DWI scans in 215 COVID-19 patients with neurological manifestations as compared 36 normal controls. The Apparent Diffusion Coefficient (ADC) was quantified tissues and regions, using an in-house MRI processing procedure. In patients, a widespread significant increase ADC found white matter. values were significantly correlated time from disease onset. alteration highest hospitalized patients. Patients disorders showed higher than...