A5051992892- Complement system in diseases
- Blood groups and transfusion
- Drug Transport and Resistance Mechanisms
- Hematopoietic Stem Cell Transplantation
- Renal Diseases and Glomerulopathies
- Protease and Inhibitor Mechanisms
- Liver Diseases and Immunity
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Liver Disease Diagnosis and Treatment
- Platelet Disorders and Treatments
- Helicobacter pylori-related gastroenterology studies
- Bone health and treatments
- Bone Metabolism and Diseases
- Acute Myeloid Leukemia Research
- Cell Adhesion Molecules Research
- Adenosine and Purinergic Signaling
- Chronic Myeloid Leukemia Treatments
- Lipid metabolism and disorders
- Gut microbiota and health
- Proteoglycans and glycosaminoglycans research
- Chemokine receptors and signaling
- Chronic Lymphocytic Leukemia Research
- Mesenchymal stem cell research
- Hemoglobinopathies and Related Disorders
- Cancer Cells and Metastasis
University of Perugia
2009-2024
University of Naples Federico II
2002-2023
Federico II University Hospital
2006-2022
Azienda Ospedaliera di Perugia
2016
University of Salerno
2016
Pharmaceutical Biotechnology (Czechia)
2006
National Research Council
2003-2006
Institute for Experimental Endocrinology and Oncology
2003-2006
IFOM
2004
Istituto Oncologico Romagnolo
1988
Background Adipocytes from mesenteric white adipose tissue amplify the inflammatory response and participate in inflammation-driven immune dysfunction Crohn's disease by releasing proinflammatory mediators. Peroxisome proliferator-activated receptors (PPAR)-α -γ, pregnane x receptor (PXR), farnesoid (FXR) liver x-receptor (LXR) are ligand-activated nuclear that provide counter-regulatory signals to dysregulated immunity modulates tissue. Aims To investigate expression function of intestinal...
Complement blockade by eculizumab is clinically effective in hemolytic paroxysmal nocturnal hemoglobinuria. However, the response variable and some patients remain dependent on red blood cell transfusions. In 72 with hemoglobinuria we tested hypothesis that may depend genetic polymorphisms of complement-related genes. We found no correlation between complement component C3 genotypes need for On other hand, a significant HindIII polymorphism regulatory gene, receptor 1 (CR1) gene. At this...
While patients with nonalcoholic fatty liver disease (NAFLD) are at increased risk to develop clinically meaningful cardiovascular diseases (CVD), there no approved drug designed target the and CVD component of NAFLD. GPBAR1, also known as TGR5, is a G protein coupled receptor for secondary bile acids. In this study we have investigated effect GPBAR1 activation by BAR501, selective agonist, in Apolipoprotein E deficient (ApoE-/-) mice fed high fat diet fructose (Western diet), validated...
Although osteoporosis is a relatively common complication after allogeneic stem cell transplantation, the role of bisphosphonates in its management has not yet been completely established. Thirty-two patients who underwent transplantation were prospectively evaluated for bone mineral density (BMD) at lumbar spine (LS) and femoral neck (FN) median period 12.2 months. Then, 15 with or rapidly progressing osteopenia (bone loss > 5%/yr) received three monthly doses 4 mg zoledronic acid...
C5 blockade by eculizumab prevents complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). However, C3-bound PNH red blood cells (RBCs), arising almost all treated patients, may undergo extravascular reducing clinical benefits. Despite the uniform deficiency of CD55 and CD59, there are always two distinct populations RBCs, with (C3+) without (C3-) C3 binding.To investigate this paradox, phenomenon has been modeled vitro incubating RBCs from untreated...
A growing body of evidence suggests that probiotic functionality is not accurately predicted by their taxonomy. Here, we have set up a study to investigate the effectiveness two formulations containing blend seven bacterial species in modulating intestinal inflammation rodent models colitis, induced treating mice with 2,4,6-Trinitrobenzenesulfonic acid (TNBS) or dextran sodium sulfate (DSS). Despite taxonomy being similar, only one preparation (Blend 2-Vivomixx) effectively attenuated...
The farnesoid-x-receptor (FXR) is a ubiquitously expressed nuclear receptor selectively activated by primary bile acids.FXR validated pharmacological target. Herein, the authors review preclinical and clinical data supporting development of FXR agonists in treatment nonalcoholic fatty liver disease.Development systemic to treat metabolic disease has been proven challenging because side effects associated with these agents including increased levels cholesterol LDL-c reduced HDL-c raising...
The leukemia inhibitory factor (LIF), is a cytokine belonging to IL-6 family, whose overexpression correlate with poor prognosis in cancer patients, including pancreatic ductal adenocarcinoma (PDAC). LIF signaling mediate by its binding the heterodimeric receptor (LIFR) complex formed LIFR and Gp130, leading JAK1/STAT3 activation. Bile acids are steroid that modulates expression/activity of membrane nuclear receptors, Farnesoid-X-Receptor (FXR) G Protein Acid Activated Receptor...
Abstract The urokinase‐type plasminogen activator ( uPA ) receptor uPAR focuses proteolytic activity on the cell membrane, promoting localized degradation of extracellular matrix ECM ), and binds vitronectin VN mediating adhesion to . ‐bound induce proteolysis‐independent intracellular signalling, regulating adhesion, migration, survival proliferation. cross‐talks with CXCR 4, for stroma‐derived factor 1 chemokine. 4 is crucial in trafficking hematopoietic stem cells from/to bone marrow,...
Non-alcoholic steatohepatitis (NASH) is a progressive, chronic, liver disease whose prevalence growing worldwide. Despite several agents being under development for treating NASH, there are no drugs currently approved. The Farnesoid-x-receptor (FXR) and the G-protein coupled bile acid receptor 1 (GPBAR1), two activated receptors, have been investigated their potential in NASH. Here we report that BAR502, steroidal dual ligand FXR/GPBAR1, attenuates of clinical histopathology features NASH...
Pelargonidins are anthocyanidins thought to be beneficial for the human health, although controversies exist over doses needed and unclear mechanism of action, along with poor systemic bioavailability. One putative target pelargonidins is aryl hydrocarbon receptor (AhR). A synthetic pelargonidin (Mt-P) was synthesized by methylation (the natural compound indicated as P). Mt-P transactivated AhR an EC50 1.97 µM ~2-fold more potent than compound. In vitro attenuated pro-inflammatory activities...