A5019461567- Complement system in diseases
- Blood groups and transfusion
- Renal Diseases and Glomerulopathies
- Immune Cell Function and Interaction
- Platelet Disorders and Treatments
- T-cell and B-cell Immunology
- Adenosine and Purinergic Signaling
- Erythrocyte Function and Pathophysiology
- Hemoglobinopathies and Related Disorders
- Neonatal Health and Biochemistry
- Acute Myeloid Leukemia Research
- Gastrointestinal disorders and treatments
- Immunotherapy and Immune Responses
- Gastrointestinal Bleeding Diagnosis and Treatment
- Delphi Technique in Research
- Patient Satisfaction in Healthcare
- Vaccine Coverage and Hesitancy
- Prostate Cancer Treatment and Research
- Hematopoietic Stem Cell Transplantation
- Influenza Virus Research Studies
- Cytomegalovirus and herpesvirus research
- Spinal Dysraphism and Malformations
- Hippo pathway signaling and YAP/TAZ
- Management of metastatic bone disease
- Esophageal and GI Pathology
Istituto per lo Studio e la Prevenzione Oncologica
2018-2024
Meyer Children's Hospital
2021-2022
University of Florence
2021-2022
Piedmont Reference Center for Epidemiology and Cancer Prevention
2020
Tumour Institute of Tuscany
2010-2017
Federico II University Hospital
2007-2015
University of Naples Federico II
2004-2010
National Academy of Medicine
1965
Complement blockade by eculizumab is clinically effective in hemolytic paroxysmal nocturnal hemoglobinuria. However, the response variable and some patients remain dependent on red blood cell transfusions. In 72 with hemoglobinuria we tested hypothesis that may depend genetic polymorphisms of complement-related genes. We found no correlation between complement component C3 genotypes need for On other hand, a significant HindIII polymorphism regulatory gene, receptor 1 (CR1) gene. At this...
The discovery of translocations that involve one the genes ETS family (ERG, ETV1, ETV4 and ETV5) has been a major advance in understanding molecular basis prostate cancer (PC). Each these results deregulated expression proteins. Here, we focus on mechanism whereby overexpression gene mediates oncogenesis prostate. By siRNA technology, show inhibition PC3 cell line reduces not only mobility anchorage-independent growth, but also proliferation, cycle progression tumor growth xenograft model....
We analyzed the autologous NK cell interaction with gliadin-presenting dendritic cells. Gliadin is known Ag priming celiac disease (CD) pathogenesis. demonstrate that gliadin prevents immature cells (iDCs) elimination by Furthermore, cooperation between human cells-iDCs and T increases IFN-gamma production of anti-gliadin immune response. fractions were for their capability to stabilize HLA-E molecules. The alpha omega conferred protection from lysis iDCs increased expression. pancreatic...
Forty-four dogs naturally infected by Leishmania infantum were divided into two groups: 20 thrombocytopenic with fewer than 150 x 10(9) platelets/l, and 24 non-thrombocytopenic more 200 platelets/l. Ten clinically healthy used as controls. A haematological profile was obtained the dogs' serum to assess presence of platelet-binding IgM IgG antibodies using a flow cytometry technique. Nineteen dogs, 13 had detectable levels immunoglobulins, but none control did so. The differences...
Summary The myelodysplastic syndromes (MDS) are clonal disorders characterised by ineffective haematopoiesis with high risk of leukaemia progression. relevance immune‐dysregulation for emergence, dominance and progression dysplastic clones has been suggested, but valuable criteria to obtain insight into these connections lacking. This study showed significant increase CD8 lymphocytes mature B cells in the bone marrow (BM) compared peripheral blood (PB) low MDS patients. Different BM levels...
C5 blockade by eculizumab prevents complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). However, C3-bound PNH red blood cells (RBCs), arising almost all treated patients, may undergo extravascular reducing clinical benefits. Despite the uniform deficiency of CD55 and CD59, there are always two distinct populations RBCs, with (C3+) without (C3-) C3 binding.To investigate this paradox, phenomenon has been modeled vitro incubating RBCs from untreated...
Abstract Background ETV4 is one of the ETS proteins overexpressed in prostate cancer (PC) as a result recurrent chromosomal translocations. In human cell lines, promotes migration, invasion, and proliferation; however, its role PC has been unclear. this study, we have explored effects expression novel transgenic mouse model. Methods We created model with prostate-specific (ETV4 mice). By histochemical molecular analysis, investigated these engineered mice p21, p27, p53. The implications our...
Abstract Aim To ascertain a delay in attendances to the emergency department (ED) during 2020 lockdown. Methods Area‐based cohort study on paediatric (0‐15 years) resulting hospital admission Tuscany, Italy, February‐May 2020, and corresponding periods 2018‐19. We analysed times from symptom onset arrival, odds of arriving late (>90th centile time) paediatricians’ judgements presentation by logistic models. Results As expected, ED attendance fell sharply (−62%) vs for cases studied (455...
Abstract Paroxysmal nocturnal haemoglobinuria (PNH) is a haematopoiesis disorder characterized by the expansion of stem cell bearing somatic mutation in phosphatidylinositol glycan-A (PIG-A) gene, which involved biosynthesis glycosylphosphatidylinositol (GPI) anchor. A number data suggest inability PIG-A to account alone for clonal dominance GPI-defective clone and development PNH. In this context, additional immune-mediated mechanisms have been hypothesized. We focused on analysis T...
Abstract This study focuses on the differential role of CD40 and CD80 costimulatory molecules major histocompatibility complex class I (MHC‐I) antigens in regulation interplay between dendritic cells (DCs) interleukin (IL)‐2‐activated human natural killer (NK) lymphocytes. Our data indicate that might play a preferential induction cytotoxic function but not interferon‐γ(IFN‐γ) production by IL‐2‐activated NK effectors presence autologous allogeneic DCs. In addition, critical CD94‐dependent...