A5058054705- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Mass Spectrometry Techniques and Applications
- Cancer-related gene regulation
Istituto per lo Studio e la Prevenzione Oncologica
2020-2023
University of Siena
2020
Abstract Background ETV4 is one of the ETS proteins overexpressed in prostate cancer (PC) as a result recurrent chromosomal translocations. In human cell lines, promotes migration, invasion, and proliferation; however, its role PC has been unclear. this study, we have explored effects expression novel transgenic mouse model. Methods We created model with prostate-specific (ETV4 mice). By histochemical molecular analysis, investigated these engineered mice p21, p27, p53. The implications our...
ETV4, one of ETS proteins overexpressed in prostate cancer, promotes migration, invasion, and proliferation cells. This study identifies a series previously unknown ETV4 alternatively spliced transcripts human cell lines. Their expression has been validated using several unbiased techniques, including Nanopore sequencing. Most these originate from an in-frame exon skipping and, thus, are expected to be translated into protein isoforms. Functional analysis the most abundant among isoforms...