A5027382532- Cannabis and Cannabinoid Research
- Immune Cell Function and Interaction
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- T-cell and B-cell Immunology
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Immunotherapy and Immune Responses
- History of Medicine Studies
- Cancer, Lipids, and Metabolism
- GABA and Rice Research
- Medicine and Dermatology Studies History
- PARP inhibition in cancer therapy
- Biochemical effects in animals
- SARS-CoV-2 and COVID-19 Research
- Plant biochemistry and biosynthesis
- Cancer-related Molecular Pathways
- Lipoproteins and Cardiovascular Health
- Ubiquitin and proteasome pathways
- Cholesterol and Lipid Metabolism
- Psychedelics and Drug Studies
- Cancer, Hypoxia, and Metabolism
- Inflammasome and immune disorders
- Retinoids in leukemia and cellular processes
- Immune responses and vaccinations
University of Salerno
2015-2024
Institute for Experimental Endocrinology and Oncology
2011-2016
University of Pisa
2016
University of Naples Federico II
2002-2004
Hebrew University of Jerusalem
1972-1974
Tel Aviv University
1974
Δ<sup>9</sup>-Tetrahydrocannabinol (THC) exhibits antitumor effects on various cancer cell types, but its use in chemotherapy is limited by psychotropic activity. We investigated the activities of other plant cannabinoids, i.e., cannabidiol, cannabigerol, cannabichromene, cannabidiol acid and THC acid, assessed whether there any advantage using <i>Cannabis</i> extracts (enriched either or THC) over pure cannabinoids. Results obtained a panel tumor lines clearly indicate that, five natural...
Abstract Background Understanding how HLA polymorphisms may affect both susceptibility, course and severity of Covid-19 infection could help at the clinical level to identify individuals higher risk from disease epidemiological one explain differences in epidemic trend among countries or even within a specific country. Italy showed peculiar geographical distribution northern most affected regions southern ones only slightly touched. Methods In this study we analysed regional frequencies for...
The fruit of Garcinia mangostana (mangosteen) is known in ancient traditional Asian medicine for its antioxidant, anti-inflammatory, immunomodulatory and anticancer activities. These effects are mainly due to the action polyphenols as xanthones, which contained pericarp fruit. In recent years, there has been a growing interest from pharmaceutical companies formulating new topicals based on mangosteen full extracts prevent skin aging. However, molecules responsible these mechanisms involved...
The endocannabinoid system has been shown to modulate key cell-signaling pathways involved in cancer cell growth. In this study, we show that cannabinoid receptor type 1 (CB1) antagonist Rimonabant (SR141716) inhibited human breast proliferation, being more effective highly invasive metastatic MDA-MB-231 cells than less-invasive T47D and MCF-7 cells. SR141716 antiproliferative effect was not accompanied by apoptosis or necrosis characterized a G<sub>1</sub>/S-phase cycle arrest, decreased...
Abstract Endocannabinoids are now emerging as suppressors of key cell‐signaling pathways involved in cancer cell growth, invasion, and metastasis. We have previously observed that the metabolically stable anandamide analog, 2‐methyl‐2′‐F‐anandamide (Met‐F‐AEA) can inhibit growth thyroid vivo. Our hypothesis was anti‐tumor effect could be at least part ascribed to inhibition neo‐angiogenesis. Therefore, aim this study assess anti‐angiogenic activity Met‐F‐AEA, investigate molecular mechanisms...
This study was designed to determine the molecular mechanisms underlying anti-proliferative effect of endocannabinoid anandamide on highly invasive human breast cancer cells, MDA-MB-231. We show that a metabolically stable analogue anandamide, Met-F-AEA, induces an S phase growth arrest correlated with Chk1 activation, Cdc25A degradation and suppression Cdk2 activity. These findings demonstrate Met-F-AEA induced cell cycle blockade relies modulated expression activity key regulatory...
Abstract Increasing evidence suggest the role of cannabinoid receptors (CBs) in control cell survival or death and signaling pathways involved tumor progression. Cancer lines are characterized by a subtle modulation CB levels which produces modified responsiveness to specific ligands, but molecular mechanisms underlying these events poorly partially understood. We previously provided that endocannabinoid (EC) anandamide (AEA) exerts anti‐proliferative effect likely expression genes cellular...
In this report we show, by confocal analysis of indirect immunofluorescence, that the type‐1 cannabinoid receptor (CB1R), which belongs to family G‐protein‐coupled receptors, is expressed on plasma membrane in human breast cancer MDA‐MB‐231 cells. However, a substantial proportion present lysosomes. We found CB1R associated with cholesterol‐ and sphyngolipid‐enriched domains (rafts). Cholesterol depletion methyl‐β‐cyclodextrin (MCD) treatment strongly reduces flotation protein raft‐fractions...