A5102881837- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Hepatitis B Virus Studies
- Animal Virus Infections Studies
- Biochemical and Molecular Research
- HIV-related health complications and treatments
- Antibiotic Resistance in Bacteria
- Streptococcal Infections and Treatments
- Antifungal resistance and susceptibility
- Antimicrobial Resistance in Staphylococcus
- Fungal Infections and Studies
- SARS-CoV-2 detection and testing
- Viral-associated cancers and disorders
- Mycobacterium research and diagnosis
- Renal Transplantation Outcomes and Treatments
- vaccines and immunoinformatics approaches
- PARP inhibition in cancer therapy
- Machine Learning in Bioinformatics
- Genomics and Rare Diseases
- HIV/AIDS oral health manifestations
University of Padua
2013-2025
Regione Puglia
2011
University of Siena
2007
Azienda Ospedaliera di Padova
2005
University of Verona
2001-2004
Abstract In December 2019, an initial cluster of interstitial bilateral pneumonia emerged in Wuhan, China. A human-to-human transmission was assumed and a previously unrecognized entity, termed coronavirus disease-19 (COVID-19) due to novel (SARS-CoV-2) described. The infection has rapidly spread out all over the world Italy been first European country experiencing endemic wave with unexpected clinical severity comparison Asian countries. It shown that SARS-CoV-2 utilizes angiotensin...
A study including 166 subjects was performed to investigate the frequency and persistence over a 6-month interval of concurrent oral anal Human Papillomavirus (HPV) infections in Immunodeficiency Virus (HIV)-infected men who have sex with (MSM).Patients no previously documented HPV-related anogenital lesion/disease were recruited participate longitudinal study. Polymerase chain reaction (PCR) detect HPV from swabs Herpes 8 (HHV-8) DNA saliva on 2 separate specimen series, one collected at...
Objectives Although deep neck infections are less common nowadays because of the widespread use antibiotics, they continue to carry significant morbidity and mortality rates. Methods Between 2000 2008, were treated in 233 patients at University Padova. Cases peritonsillar abscess, superficial infections, due external injuries, head tumors excluded. Clinical, radiologic, laboratory, microbiological assessments analyzed. Results The site origin was identified 189 cases (81.1%), most cause...
This study aimed to describe the longitudinal evolution of neutralizing antibody titres (NtAb) in three different cohorts healthcare workers (HCWs), including vaccinated HCWs with and without a previous SARS-CoV-2 infection previously infected unvaccinated HCWs. COVID-19 was mild or asymptomatic those experiencing infection.NtAb tested before BNT162b2 mRNA vaccine (V0), 20±2 days after first dose (V1_20), 20±3 (V2_20) 90±2 (V2_90) second about 2 months (N_60), 10 (N_300) 13 (N_390) from...
ObjectivesTo measure SARS-CoV-2 neutralizing antibody (NtAb) titres in previously infected or uninfected health care workers who received one two doses of BNT162b2 mRNA COVID-19 vaccine.MethodsNtAbs were titrated as dose-inhibiting 50% virus replication (ID50) by live microneutralization. We evaluated 41 recovering from mild asymptomatic infection at first vaccination dose (T1_inf) and 21 days later (T2_inf). Sixteen 20 after (T2_uninf) second vaccine (T3_uninf).ResultsAt T2_inf, but not...
Invasive fungal infections, significantly impact hospitalized and immunocompromised populations. Recent trends showed a shift from Candida albicans to non-albicans (NAC) species, raising concerns about antifungal resistance. Our study focuses on the distribution of species in blood cultures obtained different healthcare settings, including hospitals, long-term care facilities, community health centers Venetian region Italy. We retrospectively analyzed all consecutive culture isolates across...
Abstract Background Invasive fungal infections (IFIs) are a major global health issue.1 Candida species, especially albicans, the leading cause of IFIs. Non-albicans (NAC) species such as C. glabrata, tropicalis, and parapsilosis have become more prevalent.2 This study examines distribution in blood cultures trend antifungal susceptibility Venetian region Italy. Methods retrospective analyzed isolates from collected between January 2019 December 2023 region. Samples were sourced 5 hospitals,...
Journal Article Characterization of a case virological failure after switch to long-acting cabotegravir and rilpivirine Get access Maria Mazzitelli, Mazzitelli Infectious Tropical Diseases Unit, Padua University Hospital, Padua, Italy Corresponding author. E-mail: m.mazzitelli88@gmail.com https://orcid.org/0000-0003-0263-0703 Search for other works by this author on: Oxford Academic PubMed Google Scholar Antonio Avolio, Avolio Laboratory Clinical Pharmacology Pharmacogenetics, Department...
Genotypic antiretroviral testing is recommended for newly infected drug-naive subjects, and the material of choice plasma RNA. Since drug resistance mutations (DRMs) may persist longer in cellular DNA than RNA, we investigated whether use peripheral blood mononuclear cell (PBMC) human immunodeficiency virus (HIV) increases sensitivity genotypic antiretroviral-drug-naive subjects. We compared rate primary RNA PBMC 288 HIV type 1-infected persons tested at a single clinical virology center...
Abstract The clinical manifestations of SARS-CoV-2 infection vary widely among patients, from asymptomatic to life-threatening. Host genetics is one the factors that contributes this variability as previously reported by COVID-19 Genetics Initiative (HGI), which identified sixteen loci associated with severity. Herein, we investigated genetic determinants mortality, performing a case-only genome-wide survival analysis, 60 days after infection, 3904 patients GEN-COVID and other European...
The aim of this study was to evaluate whether the presence anti-hepatitis B (HBV) c antibodies (HBcAb positivity) could influence control HIV viremia in patients living with (PLWH) who switch two-drug antiretroviral therapy (2DR) containing lamivudine (3TC) (2DR-3TC-based). A retrospective multicentre observational conducted on 160 PLWH switching 2DR-3TC-based regimen: 51 HBcAb-positive and 109 HBcAb-negative patients. group demonstrated a significantly lower percentage subjects viral...
ABSTRACT In 32 patients for whom highly active antiretroviral therapy was failing, a good agreement between drug resistance-associated mutations in plasma and peripheral blood mononuclear cells (PBMCs) found ( k = 0.85). The with the lowest were 20R, 63P, 84V protease gene 184V reverse transcriptase gene. eight patients, primary resistance detected only PBMCs.
We report the case of successful use cefiderocol (FDC) in a Carbapenemase Producing K. pneumoniae (CPKP) post-surgical meningitis 44-year-old man treated with antimicrobial therapy and external ventricular drainage (EVD). The patient was known for being colonised by CPKP; this reason, ceftazidime/avibactam (CZA) plus fosfomycin linezolid started. After an initial response CZA resistant CPKP strain isolated from CSF culture, so antibiotic modified to FDC trimethoprim/sulfamethoxazole 14 days,...
Abstract We employed a multifaceted computational strategy to identify the genetic factors contributing increased risk of severe COVID-19 infection from Whole Exome Sequencing (WES) dataset cohort 2000 Italian patients. coupled stratified k -fold screening, rank variants more associated with severity, training multiple supervised classifiers, predict severity based on screened features. Feature importance analysis tree-based models allowed us 16 highest support which, together age and gender...
The aim of this study was to compare amprenavir pharmacokinetics in HIV/hepatitis C virus (HCV)-co-infected cirrhotic patients receiving non-boosted fosamprenavir 700 mg twice daily with HCV/HIV-co-infected non-cirrhotic subjects and HIV-mono-infected fosamprenavir/ritonavir 700/100 daily. Liver stiffness at baseline alanine aminotransferase levels during follow-up were measured order find a correlation between drug liver fibrosis or hepatotoxicity.Amprenavir plasma concentration determined...
The results of tuberculosis (TB) screening and reactivation in a cohort 323 adult patients undergoing haematopoietic stem cell transplantation (HSCT) from 2015 to 2019 at the University Hospital Tor Vergata, Rome, Italy, were reported. A total 260 patients, 59 (18.3%) autologous 264 (81.7%) allogeneic transplants, underwent Interferon Release (IFN)-γ (IGRA) test screening: 228 (87.7%) negative, 11 (4.2%) indeterminate 21 (8.1%) positive. Most IGRA-positive Italian origin (95.2%)...
ABSTRACT Whether highly active antiretroviral therapy (HAART) should be modified in patients with persistent increases CD4 + T cells despite detectable viral loads is an unresolved question. Forty-three heavily pretreated human immunodeficiency virus (HIV)-infected virologic failure during HAART were studied before a change of guided by genotypic analysis and follow-up. Patients increase cell count (>100 cells/ml) over pre-HAART values considered to discordant (20 individuals), whereas...