A5093871668- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
- Genetics and Neurodevelopmental Disorders
- BRCA gene mutations in cancer
- COVID-19 Clinical Research Studies
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Lung Cancer Research Studies
- Neurogenetic and Muscular Disorders Research
- Occupational and environmental lung diseases
- Bioinformatics and Genomic Networks
- Epigenetics and DNA Methylation
University of Siena
2024
Azienda Ospedaliera Universitaria Senese
2024
Abstract The clinical manifestations of SARS-CoV-2 infection vary widely among patients, from asymptomatic to life-threatening. Host genetics is one the factors that contributes this variability as previously reported by COVID-19 Genetics Initiative (HGI), which identified sixteen loci associated with severity. Herein, we investigated genetic determinants mortality, performing a case-only genome-wide survival analysis, 60 days after infection, 3904 patients GEN-COVID and other European...
Lung cancer (LC) continues to be an important public health problem being the most common form of and a major cause deaths worldwide. Despite great bulk research identify genetic susceptibility genes by genome-wide association studies, only few loci associated nicotine dependence have been consistently replicated. Our previously published study in phenotypically discordant sib-pairs identified combination germline truncating mutations known never smoker early-onset LC patient does not...
Lung cancer, including both non-small cell lung cancer and small remains the leading cause of cancer-related mortality worldwide representing 18% total deaths in 2020. Many patients are identified already at an advanced stage with metastatic disease have a worsening prognosis. Recent advances genetic understanding opened new avenues for personalized treatments targeted therapies. This review examines latest discoveries genetics discusses key biomarkers, analyzes current clinical therapies...
Lung cancer (LC) continues to be an important public health problem, being the most common form of and a major cause deaths worldwide. Despite great bulk research identify genetic susceptibility genes by genome-wide association studies, only few loci associated nicotine dependence have been consistently replicated. Our previously published study in phenotypically discordant sib-pairs identified combination germline truncating mutations known never-smoker early-onset LC patients, which does...