Stefania Mantovani
A5064069847- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- melanin and skin pigmentation
- Amyotrophic Lateral Sclerosis Research
- Immune cells in cancer
- Respiratory viral infections research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammasome and immune disorders
- Mitochondrial Function and Pathology
- PARP inhibition in cancer therapy
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Extracellular vesicles in disease
- Long-Term Effects of COVID-19
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Sphingolipid Metabolism and Signaling
- ATP Synthase and ATPases Research
- Urban Planning and Valuation
Policlinico San Matteo Fondazione
2013-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
University of Pavia
2012-2020
Fondazione Salvatore Maugeri
2000-2011
Christie's
2002
Abstract In December 2019, an initial cluster of interstitial bilateral pneumonia emerged in Wuhan, China. A human-to-human transmission was assumed and a previously unrecognized entity, termed coronavirus disease-19 (COVID-19) due to novel (SARS-CoV-2) described. The infection has rapidly spread out all over the world Italy been first European country experiencing endemic wave with unexpected clinical severity comparison Asian countries. It shown that SARS-CoV-2 utilizes angiotensin...
The relationship between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and host immunity is poorly understood. We performed an extensive analysis of immune responses in 32 patients with COVID-19, some whom succumbed. A control population healthy subjects was included. Patients COVID-19 had altered distribution peripheral blood lymphocytes, increased proportion mature natural killer (NK) cells low T-cell numbers. NK CD8+ T overexpressed immunoglobulin mucin domain-3 (TIM-3)...
Background: Recently, loss-of-function variants in TLR7 were identified two families which COVID-19 segregates like an X-linked recessive disorder environmentally conditioned by SARS-CoV-2. We investigated whether the represent tip of iceberg a subset male patients. Methods: This is nested case-control study we compared participants with extreme phenotype selected from Italian GEN-COVID cohort SARS-CoV-2-infected (<60 y, 79 severe cases versus 77 control cases). applied LASSO Logistic...
Background Amyotrophic lateral sclerosis (ALS) is a fatal progressive motor neuron disease, for which there are still no diagnostic/prognostic test and therapy. Specific molecular biomarkers urgently needed to facilitate clinical studies speed up the development of effective treatments. Methodology/Principal Findings We used two-dimensional difference in gel electrophoresis approach identify easily accessible samples, peripheral blood mononuclear cells (PBMC), panel protein that closely...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an RNA virus responsible for a pandemic that causes asymptomatic or paucisymptomatic infection in most individuals but may be severe interstitial pneumonia, myocarditis, kidney injury, hepatitis, distress (ARDS), multiorgan failure (MOF), and death. 1 Patients with disease (COVID-19) typically show signs of hyperinflammation characterized by exuberant host immune response leading to virus-driven cytokine release syndrome. 2A...
Abstract Toll-like receptors (TLR) are crucial components in the initiation of innate immune responses to a variety pathogens, triggering production pro-inflammatory cytokines and type I II interferons, which responsible for antiviral responses. Among different TLRs, TLR7 recognizes several single-stranded RNA viruses including SARS-CoV-2. We others identified rare loss-of-function variants X-chromosomal young men with severe COVID-19 no prior history major chronic diseases, that were...
Hepatitis C virus (HCV) persistence in the host results from inefficiencies of innate and adaptive immune responses. Most studies addressing role immunity concentrated on peripheral blood (PB) natural killer (NK) cells, whereas only limited information is available intrahepatic (IH) NK cells. We therefore examined phenotypic functional features IH PB cells paired liver biopsy venous samples 70 patients with chronic HCV infection 26 control persons subjected to cholecystectomy for gallstones...
The activating natural cytotoxicity receptor NKp30 is critical for killer (NK) cell function and tumor immune surveillance. receptor‐3 (NCR3) gene transcribed into several splice variants whose physiological relevance still incompletely understood. In this study, we investigated the role of its major ligand B7 homolog 6 (B7‐H6) in patients with hepatocellular carcinoma (HCC). Peripheral blood NK phenotype was skewed toward a defective/exhausted profile decreased frequencies cells expressing...
Abstract Natural Killer (NK) cells play a significant role in the early defense against virus infections and cancer. Recent studies have demonstrated involvement of NK both induction effector phases vaccine‐induced immunity various contexts. However, their shaping immune responses following SARS‐CoV‐2 vaccination remains poorly understood. To address this matter, we conducted comprehensive analysis cell phenotype function unexposed individuals who received BNT162b2 vaccine. We employed...
The voltage-dependent anion-selective channel isoform 1 (VDAC1) is a pivotal component in cellular metabolism and apoptosis with prominent role many cancer types, offering unique therapeutic intervention point. Through an
Abstract Granulocyte colony‐stimulating factor (G‐CSF) induces a transient mobilization of hematopoietic progenitor cells from bone marrow to peripheral blood. Our aim was evaluate safety repeated courses G‐CSF in patients with amyotrophic lateral sclerosis (ALS), assessing disease progression and changes chemokine cytokine levels serum cerebrospinal fluid (CSF). Twenty‐four ALS entered an open‐label, multicenter trial which four mannitol were administered at 3‐month intervals. Levels...
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, from whole-exome sequencing data about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting severity. First, converted into separate sets Boolean features, depending on the absence or presence each gene. An ensemble LASSO logistic regression models was identify most informative features with respect genetic...
The polymorphism L412F in TLR3 has been associated with several infectious diseases. However, the mechanism underlying this association is still unexplored. Here, we show that a marker of severity COVID-19. This increases sub-cohort males. Impaired macroautophagy/autophagy and reduced TNF/TNFα production was demonstrated HEK293 cells transfected TLR3L412F-encoding plasmid stimulated specific agonist poly(I:C). A statistically significant survival at 28 days shown COVID-19 patients treated...
<h3>Objective</h3> Sialic-acid-binding immunoglobulin-like lectin-7 (Siglec-7) is a natural killer (NK) cell inhibitory receptor associated with NK phenotypic and functional abnormalities in HIV-1 infection. We investigated the significance of NK-expressed serum soluble Siglec-7 relation to ability parameters liver necroinflammation fibrosis chronic HCV <h3>Design</h3> were evaluated 130 166 HCV-infected individuals by flow cytometry ELISA, respectively. degranulation cytokine secretion...
Polyoxometalates (POMs) are inorganic molecular clusters that exhibit significant biological activity against various pathologies, including cancer. Despite their therapeutic potential, the clinical application of POMs is limited by challenges such...
Summary Chronic hepatitis C virus ( HCV ) infection is characterized by persistent B‐cell activation, with enhanced differentiation and reduced proliferative ability. To assess the possible role of in altering subset distribution, we examined ex vivo frequencies inhibitory receptor expression 37 chronic ‐infected patients 25 healthy donors HD ). In addition, determined whether short‐term exposure to culture‐derived cc) resulted skewing and/or activation. There was a statistically significant...
The major histocompatibility complex-class I chain related proteins A and B (MICA/B) is upregulated because of cellular stress MICA/B shedding by cancer cells causes escape from NKG2D recognition favoring the emergence cancers. Cholangiocarcinoma (CCA) a relatively rare, though increasingly prevalent, primary liver characterized late clinical presentation dismal prognosis. We explored NKG2D-MICA/B axis in NK 41 patients with intrahepatic cholangiocarcinoma (iCCA). MICA/B-specific 7C6 mAb was...