A5063144652- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- HIV, Drug Use, Sexual Risk
- Viral Infections and Vectors
- Spinal Cord Injury Research
- Mosquito-borne diseases and control
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 detection and testing
- Viral Infections and Outbreaks Research
- Poxvirus research and outbreaks
- Vestibular and auditory disorders
- Text and Document Classification Technologies
- Transcranial Magnetic Stimulation Studies
- Cervical and Thoracic Myelopathy
- Herpesvirus Infections and Treatments
- Zoonotic diseases and public health
- Bacillus and Francisella bacterial research
- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology
- Hemophilia Treatment and Research
- Census and Population Estimation
- Advanced Causal Inference Techniques
Istituto Ortopedico Rizzoli
2025
Ministero della Salute
2021-2024
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2012-2022
Fondazione Bruno Kessler
2022
Regione Lombardia
2022
National Institute of Infectious Diseases
2022
University of Rome Tor Vergata
2013-2022
Joint Research Center
2022
Ministry of Health
2021
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2020
We analyzed the first 255 PCR-confirmed cases of monkeypox in Italy 2022. Preliminary estimates indicate mean incubation period 9.1 (95% CI 6.5-10.9) days, generation time 12.5 7.5-17.3) and reproduction number among men who have sex with 2.43 1.82-3.26).
Country-specific forecasts of the growing non-communicable disease (NCD) burden in ageing HIV-positive patients will be key to guide future HIV policies. We provided first national for Italy and Unites States America (USA) quantified direct cost caring these increasingly complex patients.We adapted an individual-based model USA, which followed on HIV-treatment as they aged developed NCDs (chronic kidney disease, diabetes, dyslipidaemia, hypertension, non-AIDS malignancies, myocardial...
Abstract In 2022, a global outbreak of mpox occurred, predominantly impacting men who have sex with (MSM). The rapid decline this epidemic is yet to be fully understood. We investigated the Italian by means an individual-based mathematical model calibrated surveillance data. accounts for transmission within MSM sexual contact network, in recreational and clubs attended MSM, households. indicate strong spontaneous reduction (61-87%) affected communities as possible driving factor cases....
Background Treating bone sarcomas in young children, particularly the proximal femur, is challenging because of need to preserve growth potential, maintain joint function, and conserve for future revisions. In 1997, we introduced a new technique combining vascularized fibula that preserved epiphysis substitute femoral head physis with massive allograft aimed at providing supportive scaffold autograft during growth. This approach initially showed promising results both anatomic functional...
COVID-19 vaccination is allowing a progressive release of restrictions worldwide. Using mathematical model, we assess the impact in Italy since December 27, 2020 and evaluate prospects for societal reopening after emergence Delta variant. We estimate that by June 30, 2021, allowed resumption about half pre-pandemic social contacts. In absence vaccination, same number cases obtained resuming only one third contacts, with 12,100 (95% CI: 6,600-21,000) extra deaths (+27%; 95% 15-47%)....
Background The SARS-CoV-2 variant of concern Omicron was first detected in Italy November 2021. Aim To comprehensively describe spread the 2 subsequent months and its impact on overall circulation at population level. Methods We analyse data from four genomic surveys conducted across country between December 2021 January 2022. Combining sequencing results with epidemiological records collated by National Integrated Surveillance System, reproductive number exponential growth rate are...
In Brief Study Design. Observational Study. Objective. To evaluate the effects of neurologic and non-neurologic factors on walking level performance in chronic spinal cord lesion (SCL) patients. Summary Background Data. Walking is one primary goals patients after a SCL. Several studies have demonstrated that different can affect performance. However, SCL age muscle strength always been considered major determinants walking. Methods. Sixty-five with were included. Their demographic, status...
BackgroundSeveral SARS-CoV-2 variants of concern (VOC) have emerged through 2020 and 2021. There is need for tools to estimate the relative transmissibility emerging with respect circulating strains.AimWe aimed assess prevalence co-circulating VOC in Italy their transmissibility.MethodsWe conducted two genomic surveillance surveys on 18 February March 2021 across whole Italian territory covering 3,243 clinical samples developed a mathematical model that describes dynamics strains.ResultsThe...
On September 7, 2017, three potentially autochthonous cases of chikungunya were notified in the Lazio region. An Outbreak investigation based on established surveillance system data and molecular analysis viral variant(s) conducted. Epidemiological suggested occurrence 3 main foci local transmission. The major focus involved 317 with epidemiological link area Anzio. other two occurred Rome (80 cases) Latina (8 cases). Cumulative incidence Anzio 331.4 7.13 per 100,000 residents, respectively....
Abstract Increasing evidence from neuroimaging and clinical studies has demonstrated cerebellar involvement in social cognition components, including the mentalizing process. The aim of this study was to apply transcranial direct current stimulation (tDCS) modulate excitability investigate role cerebellum plays mental state recognition. Forty-eight healthy subjects were randomly assigned different groups which anodal, cathodal, or sham tDCS (2 mA for 20 min) delivered centering electrode on...
To estimate the size and characteristics of undiagnosed HIV population in Italy 2012 applying a method that does not require surveillance data from beginning epidemic.We adapted known as 'London 2'; is estimated ratio between annual number simultaneous HIV/clinical AIDS diagnoses expected progression rate to clinical population; latter using CD4⁺ cell count distribution asymptomatic patients reported surveillance. Under-reporting/ascertainment new was also considered. Also, total people...
Abstract Background The spatial spread of many mosquito-borne diseases occurs by focal at the scale a few hundred meters and over longer distances due to human mobility. relative contributions different scales for transmission chikungunya virus require definition improve outbreak vector control recommendations. Methods We analyzed data from large mediated mosquito Aedes albopictus in Lazio region, Italy, consisting 414 reported cases between June November 2017. Using dates symptom onset,...
Abstract The SARS-CoV-2 variant of concern Omicron was first detected in Italy November 2021. Data from three genomic surveys conducted between December 2021 and January 2022 suggest that became dominant less than one month (prevalence on 3: 78.6%-83.8%) with a doubling time 2.7–3.1 days. mean net reproduction number rose about 1.15 absence to peak 1.83 for symptomatic cases 1.33 hospitalized cases, while it remained stable critical cases.
Objectives Combination antiretroviral therapy ( cART ) has become the main driver of total costs caring for persons living with HIV PLHIV ). The present study estimated short/medium‐term cost trends in response to recent evolution national guidelines and regional therapeutic protocols I taly. Methods We developed a deterministic mathematical model that was calibrated using epidemic data L azio, region located central taly about six million inhabitants. Results In B ase C S cenario, number...
Early surgical intervention remains the most successful therapy for melanoma. Despite better outcomes observed in soft tissue and lymph node metastases, results of pharmacological therapies are still disappointing. Currently, there is no standard adjuvant Low concentrations coenzyme Q10 have been demonstrated melanoma cell lines sera patients. These data clinical trials patients with other advanced cancers prompted this study long-term administration an optimized dose recombinant interferon...
The application of serological methods in HIV/AIDS routine surveillance systems to identify persons with recently acquired HIV infection has been proposed as a tool which may provide an accurate description the current transmission patterns HIV. Using information about recent it is possible estimate incidence, according model by Karon et al. 2008, that accounts for effect testing practices on number detected infected. We used data from period 2004-2008 newly diagnosed persons. These were...
Background. The relative rarity of ischemic compared with traumatic spinal cord injury (SCI) has limited a comparison the outcomes these conditions. Objective. To investigate neurological and functional recovery acute SCI. Methods. Data were derived from European Multicenter Study Spinal Cord Injury database. Patients (iSCI) or SCI (tSCI), aged 18 years older evaluated at different time points incidence: about 1 month, 3 months, 6 months. status was assessed each point by International...
Abstract Vaccination campaigns against COVID-19 are allowing the progressive release of physical distancing restrictions in many countries. However, global spread highly transmissible Delta variant has likely suppressed residual chances SARS-CoV-2 elimination through herd immunity alone. Here we assess impact vaccination program Italy since its start on December 27, 2020 and evaluate possible prospects for reopening society while at same time keeping under control. To this aim, propose a...