A5006476820- Circadian rhythm and melatonin
- Photoreceptor and optogenetics research
- Light effects on plants
- RNA Interference and Gene Delivery
- Electromagnetic Fields and Biological Effects
- Genetics, Aging, and Longevity in Model Organisms
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Mitochondrial Function and Pathology
- Nanoparticle-Based Drug Delivery
- Climate Change Communication and Perception
- MicroRNA in disease regulation
- Chemical Reactions and Isotopes
- Spaceflight effects on biology
Chongqing Medical University
2016-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2025
Wuhan University
2024
The various clock genes in normal cells, through their interaction, establish a number of positive and negative feedback loops that compose network structure. These play an important role regulating physiological activities. expression gene PER1 is decreased many types cancer. highly correlated with the initiation progression cancer by numerous downstream genes. However, it still unclear whether lower can influence other network. In this study, we used short hairpin RNA interference to knock...
Abstract Glioblastoma multiforme (GBM) is the most aggressive and common adult brain tumor. Current therapies primarily involve surgical resection, followed by chemotherapy radiotherapy. However, low survival rate due to high toxicity, side effects, poor targeting necessitates novel treatments. Post‐transcriptional regulation pathways, particularly of alternative polyadenylation based on mRNA 3′UTR, play a critical role in cell growth development progression tumors. Targeting tumor cells...
Clock genes are the core of circadian rhythms in human body and important regulating normal physiological functions. To date, research has indicated that clock gene, period 2 (PER2), is downregulated numerous types cancer, it associated with cancer occurrence progression via regulation various downstream cell cycle genes. However, remains unclear whether decreased expression PER2 influences other cells. In present study, short hairpin RNA interference was used to knockdown effectively oral...
This study investigated the effect of clock gene PER1 on expression levels other genes in networks oral squamous cell carcinoma cells.We used RNA interference mediated by short hairpin RNAs (shRNAs) to effectively knock down SCC15 human cells. Flow cytometry was detect degree proliferation and apoptosis cells after knockdown, quantitative real-time PCR mRNA CLOCK, BMAL1, PER1, PER2, PER3, DEC1, DEC2, CRY1, CRY2, TIM, CKIE, RORA, NPAS2, REV-ERBA.The index increased significantly while...