A5049361201- Epigenetics and DNA Methylation
- Circadian rhythm and melatonin
- Oral and Maxillofacial Pathology
- Soft tissue tumor case studies
- Tumors and Oncological Cases
- RNA modifications and cancer
- Psychological and Temporal Perspectives Research
- Cancer-related Molecular Pathways
- Neurological Disease Mechanisms and Treatments
- Light effects on plants
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- COVID-19 and healthcare impacts
- Dental Research and COVID-19
- COVID-19 Clinical Research Studies
Chongqing Medical University
2015-2024
China International Science and Technology Cooperation
2022-2024
Children's Hospital of Chongqing Medical University
2022-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2015-2016
Background: Accumulating evidence suggests that the abnormal expression of circadian clock gene PER1 is closely related to development and progression cancer. However, exact molecular mechanism by which induces carcinogenesis unclear. This study was conducted investigate alterations in downstream cell cycle genes, distribution, proliferation, apoptosis, vivo tumorigenicity SCC15 oral squamous carcinoma cells after downregulation. Materials methods: A stable line established constitutively...
// Han-Xue Li 1 , Xiao-Juan Fu Kai Yang Dan Chen Hong Tang Qin Zhao Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital Chongqing Medical University, 400016, China Correspondence to: Yang, e-mail: cqfyyk@hotmail.com Keywords: oral cancer, tumor, circadian clock, PER1, tumor-related genes Received: October 11, 2015 Accepted: February 20, 2016 Published: March 01, ABSTRACT Abnormal expression the clock gene PER1 is highly correlated with carcinogenesis development...
Recent studies have demonstrated that the clock gene PER1 regulates various tumor-related genes. Abnormal expressions and circadian rhythm alterations of are closely related to carcinogenesis. However, dynamic variations genes at different stages carcinogenesis remain unknown. This study was conducted investigate daily variation expression VEGF, KI67, C-MYC, P53 in carcinogenesis.Dimethylbenzanthracene used establish a golden hamster model buccal mucosa Hamsters with normal mucosa,...
Pediatric oral and maxillofacial surgeons have faced severe challenges in ward management due to their high risk of exposure during the COVID-19 epidemic. The aim this study was analyze summarize treatment methods infection prevention control measures applied emergency cases Department Oral Maxillofacial Surgery, Children's Hospital Chongqing Medical University, epidemic.In retrospective study, information collected from 256 pediatric patients who were treated January 23, 2020 August 9,...
To investigate the effect and regulatory mechanism of clock gene Per1 on proliferation,apoptosis,migration,and invasion human oral squamous carcinoma SCC15 cells.RNA interference was used to knock down in cell line. Changes proliferation apoptosis were analyzed by flow cytometry. Transwell assay carried out assess migration invasion. Real-time polymerase chain reaction detect mRNA expressions Ki-67, murine double minute 2 (MDM2), c-Myc, p53, Bax, Bcl-2, metalloproteinase (MMP)2, MMP9,...