A5103143906- Protein Structure and Dynamics
- MicroRNA in disease regulation
- Aquaculture disease management and microbiota
- Infections and bacterial resistance
- Genomics and Phylogenetic Studies
- Enzyme Catalysis and Immobilization
- Bioinformatics and Genomic Networks
- RNA Research and Splicing
- Microbial Metabolic Engineering and Bioproduction
- Machine Learning in Bioinformatics
- Mycobacterium research and diagnosis
- RNA modifications and cancer
Tianjin Institute of Industrial Biotechnology
2024
Chinese Academy of Sciences
2024
Tianjin University of Science and Technology
2024
The aim of this study was to investigate the relationship between micro ribonucleic acid (miR)-152-3p and chronic myeloid leukemia (CML), explore underlying mechanism.The expression level miR-152-3p in bone marrow 40 CML patients 30 normal controls detected by fluorescence quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). MiR-152-3p up-regulated or down-regulated cell line (K562) transfection with overexpressed lentivirus LV5-miR-152-3p interfered LV3-miR-152-3p, respectively....
A key challenge in pathway design is finding proper enzymes that can be engineered to catalyze a non-natural reaction. Although existing tools identify potential based on similar reactions, these encounter several issues. Firstly, the calculated reactions may not even have same reaction type. Secondly, associated are often numerous and identifying most promising candidate difficult due lack of data for evaluation. Thirdly, web do provide interactive functions enable users fine-tune results...
The molecular weight (MW) of an enzyme is a critical parameter in enzyme-constrained models (ecModels). It determined by two factors: the presence subunits and abundance each subunit. Although number (NS) can potentially be obtained from UniProt, this information not readily available for most proteins. In study, we addressed gap extracting curating subunit UniProt database to establish robust benchmark dataset. Subsequently, propose novel model named DeepSub, which leverages protein...