A5059749589- Antimicrobial Peptides and Activities
- Antibiotic Resistance in Bacteria
- Bacteriophages and microbial interactions
- Bacterial Genetics and Biotechnology
- Monoclonal and Polyclonal Antibodies Research
- Aquaculture disease management and microbiota
- Salmonella and Campylobacter epidemiology
- Animal Diversity and Health Studies
- Probiotics and Fermented Foods
- Phenothiazines and Benzothiazines Synthesis and Activities
- RNA and protein synthesis mechanisms
- Ecology and Conservation Studies
- Land Use and Ecosystem Services
- Gut microbiota and health
- Antimicrobial Resistance in Staphylococcus
- Moringa oleifera research and applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Medicinal Plants and Neuroprotection
Sichuan Agricultural University
2023-2024
Maternal and Child Health Hospital of Sichuan Province
2024
Abstract Novel therapeutic strategies against difficult-to-treat bacterial infections are desperately needed, and the faster cheaper way to get them might be by repurposing existing antibiotics. Nanodelivery systems enhance efficacy of antibiotics guiding their targets, increasing local concentration at site infection. While recently described nanodelivery promising, they generally not easy adapt different lack biocompatibility or specificity. Here, created that source targeting proteins...
Due to the accelerated appearance of antimicrobial-resistant (AMR) pathogens in clinical infections, new first-in-class antibiotics, operating via novel modes action, are desperately needed. Brevicidine, a bacterial nonribosomally produced cyclic lipopeptide, has shown potent and selective antimicrobial activity against Gram-negative pathogens. However, before our investigations, little was known about how brevicidine exerts its bactericidal effect In this study, we find that AMR...
Pullorum disease (PD) is a bacterial infection caused by Salmonella pullorum ( S. ) that affects poultry. It highly infectious and often fatal. Antibiotics are currently the mainstay of prophylactic therapeutic treatments for PD, but their use can lead to development resistance in pathogenic bacteria disruption host's intestinal flora. We added neomycin sulfate different doses tannic acid (TA) drinking water chicks at 3 days age infected them with PD intraperitoneal injection 9 age. analyzed...
The antibiotic resistance of Acinetobacter baumannii poses a significant threat to global public health, especially those strains that are resistant carbapenems. Therefore, novel strategies desperately needed for the treatment infections caused by antibiotic-resistant A. baumannii. In this study, we report brevicidine, bacterial non-ribosomally produced cyclic lipopeptide, shows synergistic effects with multiple outer membrane-impermeable conventional antibiotics against particular, at...
The rapid emergence of antibiotic-resistant strains Staphylococcus aureus presents a substantial challenge to global public health, underscoring the urgent need for novel antibiotics with diverse mechanisms action. In this study, we conducted mutagenesis on C-terminal region lantibiotic ripcin C enhance its antimicrobial efficacy against S. aureus. resulting optimized variant, CP23A, demonstrated potent and selective activity, minimal inhibitory concentration 2-4 mg/L Beyond strong...
Abstract The rise of antibiotic resistance, coupled with a dwindling pipeline, presents significant threat to public health. Consequently, there is an urgent need for novel therapeutics targeting antibiotic‐resistant pathogens. Nisin, promising peptide antibiotic, exhibits potent bactericidal activity through mechanism distinct from that clinically used antibiotics. However, its cationic nature leads hemolysis and cytotoxicity, which has limited clinical application. Here, nanodelivery...
<title>Abstract</title> Novel therapeutic strategies against difficult-to-treat bacterial infections are desperately needed, and the faster cheaper way to get them might be by repurposing existing antibiotics. Nanodelivery systems enhance efficacy of antibiotics guiding their targets, increasing local concentration at site infection. While recently described nanodelivery promising, they generally not easy adapt different lack biocompatibility or specificity. Here, created that source...
To understand the distribution characteristics and restoration status of vegetation at Sanxingdui City Wall, we sampled five typical communities city wall site explored stability niche herbaceous plant under different maintenance measures (natural regeneration, planting, abandoned field, shrub removal, pruning) following theory improved contribution law method. A total 87 species belonging to 73 genera 31 families were recorded. Compositae Gramineae dominant, perennial herbs majority. There...
Abstract Due to the accelerated appearance of antibiotic-resistant (AMR) pathogens in clinical infections, new first-in-class antibiotics, operating via novel modes action, are desperately-needed. Brevicidine, a bacterial non-ribosomally produced cyclic lipopeptide, has shown potent and selective antimicrobial activity against Gram-negative pathogens. However, before our investigations, little was known about how brevicidine exerts its bactericidal effect In this study, we find that AMR...