A5039891061- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Photoreceptor and optogenetics research
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Fetal and Pediatric Neurological Disorders
- Cardiac Arrest and Resuscitation
- Olfactory and Sensory Function Studies
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Cerebrovascular and Carotid Artery Diseases
- Nuclear Receptors and Signaling
- Neural dynamics and brain function
- Ultrasound and Hyperthermia Applications
- Lanthanide and Transition Metal Complexes
- Moyamoya disease diagnosis and treatment
- Neurogenesis and neuroplasticity mechanisms
University of Pittsburgh
2015-2024
Carnegie Mellon University
2006-2013
Northern California Institute for Research and Education
2006
San Francisco VA Medical Center
2006
University of California, San Francisco
2005-2006
Abstract APOE and Trem2 are major genetic risk factors for Alzheimer’s disease (AD), but how they affect microglia response to Aβ remains unclear. Here we report an isoform-specific phospholipid signature with correlation between human APOEε3/3 APOEε4/4 AD brain lipoproteins from astrocyte conditioned media of APOE3 APOE4 mice. Using preclinical mouse models, show that lipoproteins, unlike APOE4, induce faster microglial migration towards injected Aβ, facilitate uptake, ameliorate effects on...
This paper is motivated by the analysis of serial structural magnetic resonance imaging (MRI) data brain to map patterns local tissue volume loss or gain over time, using registration-based deformation tensor morphometry. Specifically, we address important confound contrast changes which can be induced neurodegenerative neurodevelopmental processes. These not only modify apparent volume, but also integrity and its resulting MRI parameters. In order this derive an approach voxel-wise...
Introducing optogenetics into neurovascular research can provide novel insights the cell-specific control of hemodynamic response. To generalize findings from molecular approaches, it is crucial to determine whether light-activated circuits have same effect on vasculature as sensory-activated ones. For that purpose, rats expressing channelrhodopsin (ChR2) specific excitatory glutamatergic neurons were used measure neural activity, blood flow, hemoglobin-based optical intrinsic signal, and...
White matter hyperintensity (WMH) lesions on brain MRI images are surrogate markers of cerebral small vessel disease. Longitudinal studies examining the association between diabetes and WMH progression have yielded mixed results. Thus, in this study, we investigated HbA1c, a biomarker for presence severity hyperglycemia, longitudinal change after adjusting known risk factors progression. We recruited 64 participants from South Korean memory clinics to undergo at baseline 2-year follow-up....
Purpose Glucose uptake and metabolism can be measured by chemical exchange–sensitive spin‐lock (CESL) MRI with an administration of glucose or its analogs. This study investigates the sensitivity, spatiotemporal characteristics, signal source glucoCESL a 9L rat brain tumor model. Methods Dynamic CESL intravenous injection D‐glucose, 2‐deoxy‐D‐glucose (2DG), L‐glucose were compared gadolinium‐based dynamic contrast‐enhanced (DCE) MRI. Results The signals analogs have faster larger changes in...
The interhemispheric circuit connecting the left and right mammalian brain plays a key role in integration of signals from side body. information transfer is carried out by modulation simultaneous excitation inhibition. Hemodynamic studies this are inconsistent since little known about neurovascular coupling mixed excitatory inhibitory signals. We investigated variability hemodynamic responses driven during optogenetic somatosensory activation. observed differences response based on...
We report the design of a MRI reporter gene with applications to non-invasive molecular imaging. modified mitochondrial ferritin localize cell cytoplasm. confirmed efficient cellular processing this engineered protein and demonstrated high iron loading in mammalian cells. The reporter's intracellular localization appears as distinct clusters that deliver robust contrast. used new image vivo ex expression native olfactory sensory neurons mouse epithelium. This can facilitate study mechanisms...
Abstract INTRODUCTION Compared to males, females have an accelerated trajectory of cognitive decline in Alzheimer's disease (AD). The neurobiological factors underlying the more rapid AD remain unclear. This study explored how sex‐dependent alterations hippocampal connectivity over 2 years are associated with cerebrovascular and amyloid pathologies normal aging. METHODS Thirty‐three 21 males 65 93 age no impairment performed a face‐name associative memory functional magnetic resonance...
<p dir="ltr">White matter hyperintensity (WMH) lesions on brain MRI images are surrogate markers of cerebral small vessel disease (CSVD). Longitudinal studies examining the association between diabetes and WMH progression have yielded mixed results. Thus, in this study we investigated HbA1c, a biomarker for presence severity hyperglycemia, longitudinal change after adjusting known risk factors progression. We recruited 64 participants from South Korean memory clinics to undergo at...
Functional MRI responses are localized to the synaptic sites of evoked inhibitory neurons, but it is unknown whether, or by what mechanisms, these neurons initiate functional hyperemia. Here, neuronal origins hemodynamic were investigated fMRI local field potential and blood flow measurements during topical application pharmacological agents when GABAergic granule cells in rat olfactory bulb synaptically targeted. First, examine if postsynaptic activation was required for neurovascular...
Epinephrine is the principal resuscitation therapy for pediatric cardiac arrest (CA). Clinical data suggest that although epinephrine increases rate of resuscitation, it fails to improve neurological outcome, possibly secondary reductions in microvascular flow. We characterized effect vs. placebo administered at from asphyxial CA on and macrovascular cortical perfusion assessed using vivo multiphoton microscopy laser speckle flowmetry, respectively, brain tissue oxygenation (PbO 2 ),...
In this paper we describe the application of folding measures to tracking <i>in vivo</i> cortical brain development in premature neonatal anatomy. The outer gray matter and gray-white interface surfaces were extracted from semi-interactively segmented high-resolution T1 MRI data. Nine curvature- geometric descriptor-based applied six infants, aged 28-37 weeks, using a direct voxelwise iso-surface representation. We have shown that such an approach it is feasible extract meaningful adequate...
<p dir="ltr">White matter hyperintensity (WMH) lesions on brain MRI images are surrogate markers of cerebral small vessel disease (CSVD). Longitudinal studies examining the association between diabetes and WMH progression have yielded mixed results. Thus, in this study we investigated HbA1c, a biomarker for presence severity hyperglycemia, longitudinal change after adjusting known risk factors progression. We recruited 64 participants from South Korean memory clinics to undergo at...
Cerebral microbleeds are morphologic changes contributing to the progression of Alzheimer’s Disease and vascular dementias. However, effects on brain connectivity across age sex remain be understood. In this study, we performed T2* mapping, that was registered a DTI space measure diffusion in microbleed locations. R2* tensor indices demonstrate an inverse relationship, where is low rates high. Our results suggest decrease water possibly due increased neuroinflammation hemosiderin...
<title>Abstract</title> <bold>Objective:</bold> White matter hyperintensities (WMH) on brain MRI images are the most common feature of cerebral small vessel disease (CSVD). Studies have yielded divergent findings modifiable risk factors for WMH and WMH’s impact cognitive decline. Mounting evidence suggests sex differences in burden subsequent effects cognition. Thus, we aimed to identify sex-specific WMH. We then explored whether there were associations longitudinal clinical dementia...
We collected two-photon line-scans along brain capillaries in Alzheimer's and wildtype mice. applied Radon transform to quantify red blood cell velocity found it decreasing with increased cerebral amyloid angiopathy but not tissue plaques.