A5033983195- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Memory and Neural Computing
- Conducting polymers and applications
- Neuroscience and Neuropharmacology Research
- Muscle activation and electromyography studies
- Neurological disorders and treatments
- Vagus Nerve Stimulation Research
- Electrochemical Analysis and Applications
- Photoacoustic and Ultrasonic Imaging
- Autophagy in Disease and Therapy
- Electrochemical sensors and biosensors
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Anesthesia and Neurotoxicity Research
- Advanced Fluorescence Microscopy Techniques
- Optical Imaging and Spectroscopy Techniques
- Transcranial Magnetic Stimulation Studies
- Barrier Structure and Function Studies
- 3D Printing in Biomedical Research
- Moyamoya disease diagnosis and treatment
- Dental Research and COVID-19
McGowan Institute for Regenerative Medicine
2015-2024
University of Pittsburgh
2015-2024
Center for the Neural Basis of Cognition
2015-2024
Carnegie Mellon University
2016-2024
Allen Institute for Brain Science
2015-2024
Pittsburg State University
2023
Center for Neurosciences
2018-2020
Neurotech (United States)
2016
Naruto University of Education
2014
University of Michigan
2009-2012
Abstract Advancements in neurotechnologies for electrophysiology, neurochemical sensing, neuromodulation, and optogenetics are revolutionizing scientific understanding of the brain while enabling treatments preventative measures a variety neurological disorders. The grand challenge neural interface engineering is to seamlessly integrate between neurobiology engineered technology record from modulate neurons over chronic timescales. However, biological inflammatory response implants,...
Individual carbon fiber microelectrodes can record unit activity in both acute and semi-chronic (∼1 month) implants. Additionally, new methods have been developed to insert a 16 channel array of microelectrodes. Before assessing the vivo long-term viability these arrays, accelerated soak tests were carried out determine most stable site coating material. Next, multi-animal, multi-month, chronic implantation study was with microelectrode arrays silicon electrodes.
Objective. Penetrating cortical neural probe technologies allow investigators to record electrical signals in the brain. Implantation of probes results acute tissue damage, and microglia density increases around implanted devices over weeks. However, mechanisms underlying this encapsulation are not well understood temporal domain. The objective here was evaluate dynamic microglial response using two-photon microscopy. Approach. Using vivo microscopy, ∼200 µm below surface visual cortex were...
Penetrating neural probe technologies allow investigators to record electrical signals in the brain. The implantation of probes causes acute tissue damage, partially due vasculature disruption during implantation. This trauma can cause abnormal electrophysiological responses and temporary increases neurotransmitter levels, perpetuate chronic immune responses. A significant challenge for is examine neurovascular features below surface brain vivo. objective this study was investigate localized...
Subcellular-sized chronically implanted recording electrodes have demonstrated significant improvement in single unit (SU) yield over larger probes. Additional work expands on this initial success by combining the subcellular fiber-like lattice structures with design space versatility of silicon microfabrication to further improve signal-to-noise ratio, density electrodes, and stability recorded units months years. However, ultrasmall microelectrodes present very high impedance, which must...
Single carbon fiber electrodes (d = 8.4 μm) insulated with parylene-c and functionalized
Blue laser photoelectrically and photothermally exciting a wireless carbon fiber electrode to activate nearby neuron.
Implantable neural electrode devices are important tools for neuroscience research and have an increasing range of clinical applications. However, the intricacies biological response after implantation, their ultimate impact on recording performance, remain challenging to elucidate. Establishing a relationship between neurobiology chronic performance is confounded by technical challenges related traditional electrophysiological, material, histological limitations. This can greatly...
Neural electrodes hold tremendous potential for improving understanding of brain function and restoring lost neurological functions. Multi-walled carbon nanotube (MWCNT) dexamethasone (Dex)-doped poly(3,4-ethylenedioxythiophene) (PEDOT) coatings have shown promise to improve chronic neural electrode performance. Here, we employ electrochemical techniques characterize the coating in vivo. Coated uncoated arrays were implanted into rat visual cortex subjected daily cyclic voltammetry (CV)...
Objective. The dorsal root ganglion is an attractive target for implanting neural electrode arrays that restore sensory function or provide therapy via stimulation. However, penetrating microelectrodes designed these applications are small and deliver low currents. For long-term performance of microstimulation devices, novel coating materials needed in part to decrease impedance values at the electrode-tissue interface increase charge storage capacity. Approach. Conductive polymer...
Abstract Objective. Decoding neural activity has been limited by the lack of tools available to record from large numbers neurons across multiple cortical regions simultaneously with high temporal fidelity. To this end, we developed Argo system at data rates. Approach. Here demonstrate a massively parallel recording based on platinum-iridium microwire electrode arrays bonded CMOS voltage amplifier array. The is highest channel count in vivo system, supporting simultaneous 65 536 channels,...
Abstract APOE and Trem2 are major genetic risk factors for Alzheimer’s disease (AD), but how they affect microglia response to Aβ remains unclear. Here we report an isoform-specific phospholipid signature with correlation between human APOEε3/3 APOEε4/4 AD brain lipoproteins from astrocyte conditioned media of APOE3 APOE4 mice. Using preclinical mouse models, show that lipoproteins, unlike APOE4, induce faster microglial migration towards injected Aβ, facilitate uptake, ameliorate effects on...