A5101468285- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Advanced Memory and Neural Computing
- Photoreceptor and optogenetics research
- EEG and Brain-Computer Interfaces
- Carbon and Quantum Dots Applications
- Polymer Science and PVC
- Polymer Nanocomposites and Properties
- Advanced Sensor and Energy Harvesting Materials
- Pickering emulsions and particle stabilization
- Polymer crystallization and properties
- Advanced Materials and Mechanics
- Supramolecular Self-Assembly in Materials
Science and Technology Corporation (Norway)
2024
Shandong University of Technology
2020-2023
Stanford University
2017
Abstract Objective. Decoding neural activity has been limited by the lack of tools available to record from large numbers neurons across multiple cortical regions simultaneously with high temporal fidelity. To this end, we developed Argo system at data rates. Approach. Here demonstrate a massively parallel recording based on platinum-iridium microwire electrode arrays bonded CMOS voltage amplifier array. The is highest channel count in vivo system, supporting simultaneous 65 536 channels,...
Mammalian brains consist of 10s millions to 100s billions neurons operating at millisecond time scales, which current recording techniques only capture a tiny fraction. Recording capable sampling neural activity high spatiotemporal resolution have been difficult scale. The most intensively studied mammalian neuronal networks, such as the neocortex, show layered architecture, where optimal technology samples densely over large areas. However, need for application-specific designs well...
Abstract Here we demonstrate the Argo System, a massively parallel neural recording system based on platinum-iridium microwire electrode arrays bonded to CMOS voltage amplifier array. The is highest channel count in vivo built date, supporting simultaneous from 65,536 channels, sampled at over 32 kHz and 12-bit resolution. This designed for cortical recordings, compatible with both penetrating surface microelectrodes. We have validated this by spiking activity 791 neurons rats Local Field...
Abstract Titanium dioxide (TiO 2 ) has a strong oxidation effect when absorbing ultraviolet light. Therefore, TiO is used as light stabilizer in polyvinyl chloride (PVC), it will cause the photodegradation of PVC. Herein, carbon quantum dots (CQDs) coated composite @CQDs) was prepared by one‐step hydrothermal method. The @CQDs were characterized transmission electron microscopy (TEM), UV–Vis spectroscopy, X‐ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR), and...
Brain-computer interfaces (BCIs) hold exciting therapeutic potential, but tissue damage caused by probe insertion limits channel count. Biohybrid devices, in which the cell-device interface is crafted laboratory, promise to address this limitation, these devices have lacked a demonstration of their applicability for BCI. We developed biohybrid approach engraft optogenetically-enabled neurons on cortical surface housed 2D-scaffold circular microwells. The engrafted survived, exhibited...
Fluidic control and sampling in complex environments is an important process biotechnology, materials synthesis, microfluidics. An elegant solution to this problem has evolved nature through cellular endocytosis, where the dynamic recruitment, self-assembly, spherical budding of clathrin proteins allows cells sample their external environment. Yet despite importance utility artificial systems which can replicate behavior have not been developed. Guided by clathrin's unusual structure, we...
Objective. The safe insertion of high density intracortical electrode arrays has been a long-standing practical challenge for neural interface engineering and applications such as brain-computer interfaces (BCIs). However, the pia mater can be difficult to penetrate causes deformation underlying cortical tissue during high-density arrays. This lead neuron damage or failed insertions. development method ease through would represent significant step toward inserting arrays.Approach. Here we...
Summary Mammalian brains consist of 10s millions to 100s billions neurons operating at millisecond time scales, which current recording techniques only capture a tiny fraction. Recording capable sampling neural activity such temporal resolution have been difficult scale: The most intensively studied mammalian neuronal networks, as the neocortex, show layered architecture, where optimal technology samples densely over large areas. However, need for application-specific designs well mismatch...
Abstract The safe insertion of high density intracortical electrode arrays has been a long-standing practical challenge for neural interface engineering and applications such as brain-computer interfaces (BCIs). Here we describe surgical procedure, inspired by laser corneal ablation, that can be used in large mammals to thin the pia mater, innermost meningeal layer encapsulating brain. This procedure allows microelectrode inserted into cortex with less force, thus reducing deformation...