A5098400748- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Retinal Development and Disorders
- Neural dynamics and brain function
Science and Technology Corporation (Norway)
2024
Alameda Applied Sciences Corporation (United States)
2023
Abstract Retinitis pigmentosa and macular degeneration lead to photoreceptor death loss of visual perception. Despite recent progress, restorative technologies for remain largely unavailable. Here, we describe a novel optogenetic prosthesis (FlexLED) based on combination thin-film retinal display activation ganglion cells (RGCs). The FlexLED implant is 30 µm thin, flexible, wireless µLED with 8,192 pixels, each an emission area 66 2 . affixed the surface, electronics package mounted under...
Brain-computer interfaces (BCIs) hold exciting therapeutic potential, but tissue damage caused by probe insertion limits channel count. Biohybrid devices, in which the cell-device interface is crafted laboratory, promise to address this limitation, these devices have lacked a demonstration of their applicability for BCI. We developed biohybrid approach engraft optogenetically-enabled neurons on cortical surface housed 2D-scaffold circular microwells. The engrafted survived, exhibited...