A5007257449- Photoreceptor and optogenetics research
- Neurobiology and Insect Physiology Research
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Retinal Development and Disorders
- Motor Control and Adaptation
- Inertial Sensor and Navigation
- Human-Automation Interaction and Safety
- Circadian rhythm and melatonin
- Zebrafish Biomedical Research Applications
- Robotics and Automated Systems
- Animal Behavior and Reproduction
- Island Studies and Pacific Affairs
- Gaze Tracking and Assistive Technology
Harvard University
1987-2025
Science and Technology Corporation (Norway)
2024
Alameda Applied Sciences Corporation (United States)
2023
Howard Hughes Medical Institute
2020-2021
Northern Illinois University
1987
University of Georgia
1987
University of California, Berkeley
1987
To navigate, we must continuously estimate the direction are headed in, and correct deviations from our goal
Abstract Retinitis pigmentosa and macular degeneration lead to photoreceptor death loss of visual perception. Despite recent progress, restorative technologies for remain largely unavailable. Here, we describe a novel optogenetic prosthesis (FlexLED) based on combination thin-film retinal display activation ganglion cells (RGCs). The FlexLED implant is 30 µm thin, flexible, wireless µLED with 8,192 pixels, each an emission area 66 2 . affixed the surface, electronics package mounted under...
When an animal moves through the world, its brain receives a stream of information about body’s translational movement. These incoming movement signals, relayed from sensory organs or as copies motor commands, are referenced relative to body. Ultimately, such body-centric signals must be transformed into world-centric coordinates for navigation 1 . Here we show that this computation occurs in fan-shaped body Drosophila brain. We identify two cell types body, PFNd and PFNv 2,3 , conjunctively...
Abstract To navigate, we must continuously estimate the direction are headed in, and use this information to guide our path toward goal 1 . Direction estimation is accomplished by ring attractor networks in head system 2,3 However, do not understand how sense of used action. Drosophila connectome analyses 4,5 recently revealed two cell types (PFL2 PFL3) that connect locomotor system. Here show both combine an allocentric signal with internal produce egocentric motor drive. We recorded their...
Brain-computer interfaces (BCIs) hold exciting therapeutic potential, but tissue damage caused by probe insertion limits channel count. Biohybrid devices, in which the cell-device interface is crafted laboratory, promise to address this limitation, these devices have lacked a demonstration of their applicability for BCI. We developed biohybrid approach engraft optogenetically-enabled neurons on cortical surface housed 2D-scaffold circular microwells. The engrafted survived, exhibited...
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