A5100610988- Thyroid Disorders and Treatments
- Dementia and Cognitive Impairment Research
- Scoliosis diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Alzheimer's disease research and treatments
- Celiac Disease Research and Management
- Growth Hormone and Insulin-like Growth Factors
- Vector-borne infectious diseases
- Nutritional Studies and Diet
- Spinal Fractures and Fixation Techniques
- Vector-Borne Animal Diseases
- Vitamin C and Antioxidants Research
- Folate and B Vitamins Research
- Systemic Lupus Erythematosus Research
- Liver Disease Diagnosis and Treatment
- Iron Metabolism and Disorders
- Viral Infections and Vectors
- Blood Pressure and Hypertension Studies
- Diabetes and associated disorders
- Renal Diseases and Glomerulopathies
- Adipokines, Inflammation, and Metabolic Diseases
- Mycobacterium research and diagnosis
- Medical Imaging and Analysis
- Food Allergy and Anaphylaxis Research
- Monoclonal and Polyclonal Antibodies Research
Vibrant Data (United States)
2018-2025
Chinese PLA General Hospital
2018-2024
Rush University Medical Center
2021-2024
Northeast Agricultural University
2023
Capital Medical University
2023
Tianjin University
2021-2022
Government of the United States of America
2022
Oak Ridge National Laboratory
2022
Kafkas University
2022
Atatürk University
2022
The ageing brain is vulnerable to a wide array of neuropathologies. Prior work estimated that the three most studied these, Alzheimer's disease, infarcts, and Lewy bodies, account for ∼40% variation in late life cognitive decline. However, estimate did not incorporate many other diseases are now recognized as potent drivers decline [e.g. limbic predominant age-related TDP-43 encephalopathy (LATE-NC), hippocampal sclerosis, cerebrovascular conditions]. We examined degree which person-specific...
We examined whether plasma p-tau181 and p-tau217 are specific biomarkers of pathologically confirmed Alzheimer's disease (AD). In particular, we investigated the utility p-tau for differentiating AD from primary age-related tauopathy (PART), as well with mixed pathologies. Data came 269 older adults who participated in Religious Orders Study or Rush Memory Aging Project. Blood samples were collected during annual clinical evaluations. Participants died underwent brain autopsy. P-tau181...
Even though most thyroid subjects are undiagnosed due to nonspecific symptoms, universal screening for disease is not recommended the general population. In this study, our motive showcase early appearance of autoantibody, anti-TPO, prior onset hormone disruption; hence addition anti-TPO in conjunction with traditional markers TSH and FT4 would aid reduce long-term morbidity associated health concerns. Here, a total 4581 were tested multiple times TSH, FT4, anti-Tg followed up 2 years. We...
Abstract Background Adjacent segment disease (ASD ) is an acknowledged problem of posterior lumbar interbody fusion (PLIF). Many studies have been reported concerning the role lordosis distribution index (LDI) in spinal biomechanics. However, few reports published about impact LDI on ASD following L4-S1 PLIF. Methods The study enrolled 200 subjects who underwent PLIF for degenerative spine from 2009 to 2014. average follow-up term was 84 months. Several lower parameters were measured,...
Stress, herd transfer, and food changes experienced by nursery fattening pigs can lead to reduced performance, digestion absorption, impaired intestinal health. Given the role of essential oils in relieving stress improving animal welfare, we hypothesized that may improve pig performance via promoting gut health homeostasis laid EOs supplementation during continuously impacts pigs.A total 100 piglets (Landrace × Large White; weighted 8.08 ± 0.34 kg, weaned at d 28) were randomly selected...
To evaluate the association between thyroid disease and diabetes markers. Retrospective cohort study. The study was conducted in a diagnostic setting where primary care providers recommended patients to test for panels. markers were tested 32 787 subjects with suspected related conditions who visited Vibrant America Clinical Laboratory January 2015 June 2019. Our general prevalence results showed that homeostatic model assessment-insulin resistance (HOMA-IR) elevated overt hypothyroid...
Introduction Cardiovascular diseases (CVDs) remain the leading cause of mortality globally. The role micronutrients in maintaining cardiovascular health has gained increasing attention, as deficiencies or imbalances vitamins, minerals, and amino acids may influence risk progression CVDs. This study aimed to evaluate relationship between serum micronutrient levels critical lipid lipoprotein markers indicative health. Materials methods A retrospective analysis was conducted on 358 individuals...
To test the hypothesis that higher level of cognitive activity predicts older age at dementia onset in Alzheimer disease (AD) dementia.
<b><i>Objective:</i></b> To investigate correlations between hypertensive patients' knowledge of hypertension, awareness hypertension education, self-management behaviors, and control. <b><i>Methods:</i></b> Hypertensive patients from 5 community health centers in Xuhui District, Shanghai, China, were enrolled into this study. Data collected via patient interviews a questionnaire survey. Independent influence factors for control identified by...
Micronutrients are involved in various vital cellular metabolic processes including thyroid hormone metabolism. This study aimed to investigate the correlation between serum levels of micronutrients and their effects on parameters. The markers was studied a group 387 healthy individuals tested for (T4, T3, FT4, FT3, TSH, anti-TPO, RT3, anti-Tg) micronutrient profile at Vibrant America Clinical Laboratory. subjects were rationalized into three groups (deficient, normal, or excess...
Optimal intestinal health and functionality are essential for animal performance, simultaneously nutrient transporters peptides also involved in appetite food intake control mechanisms. Given the potential of oil (EO) improving performance feed palatability, we hypothesized that dietary supplementation cinnamaldehyde carvacrol could improve nursery pigs by modulating microbiota. Cinnamaldehyde (100 mg/kg), their mixtures (including 50 mg/kg carvacrol) were supplemented into diets 240 42 d,...
This preclinical study examines light fluence, photodynamic therapy (PDT) dose and "apparent reacted singlet oxygen," [1 O2 ]rx , to predict local control rate (LCR) for Photofrin-mediated PDT of radiation-induced fibrosarcoma (RIF) tumors. Mice bearing RIF tumors were treated with in-air fluences (50-250 J cm-2 ) fluence rates (50-150 mW at Photofrin dosages 5 15 mg kg-1 a drug-light interval 24 h using 630-nm, 1-cm-diameter collimated laser. A macroscopic model was used calculate based on...
Background This study tested the hypothesis that sarcopenia and its constituent components, reduced lean muscle mass impaired motor function, are associated with survival increased risk of incident disabilities. Methods 1466 community-dwelling older adults underwent assessment bioelectrical impedance analysis (BIA), grip strength, gait speed other components physical frailty annual self-report assessments disability. We used Cox proportional hazards models controlled for age, sex, race,...
Introduction . Individuals with one autoimmune disease are at risk of developing a second disease, but the pathogenesis or sequential occurrence multiple diseases has not been established yet. In this study, we explored association and antibodies in thyroid systemic subjects. We evaluated hormones, thyroid-stimulating hormone (TSH), free thyroxine (FT4), autoantibodies, anti-thyroperoxidase (anti-TPO), anti-thyroglobulin (Tg) to comprehend anti-nuclear (ANA), autoantibodies extractable...
Renal involvement is a common occurrence in subjects with systemic autoimmune diseases. The renal manifestation and its severity depend on the underlying condition may reversely complicate clinical course of function markers have been widely used assessment normal functioning kidneys including glomerular filtration rate concentrating diluting capacity kidney. An increase or decrease values these indicate kidney dysfunction. In this study, number critical were examined seropositive diseases...
This study aimed to systematically evaluate the factors influencing restoration of spontaneous circulation (ROSC) after cardiopulmonary arrest (CA).Relevant papers on ROSC in patients with CA were retrieved from PubMed, Embase, Cochrane Library, China Biology Medicine disk, National Knowledge Infrastructure, Wanfang, and VIP databases. After screening, data extraction, quality evaluation papers, a meta-analysis was carried out.A total 36 involving sample size 2,305 cases, included. The...
Background: Multidrug-resistant pulmonary tuberculosis (MDR-PTB) has become a major cause of high morbidity and mortality related to TB. Conventional drug regimens are ineffective for the treatment MDR-PTB patients with cavities. This study aimed evaluate clinical efficacy safety one-way endobronchial valves (EBVs) cavities in patients. Methods: positive sputum cultures, smears, were treated EBVs drainage bronchus cavity between November 2013 March 2018. The participants comprised those who...
Objective: To study the relationship between cancer patient/research participants' perceptions of communication with their research nurse and doctor (1) thoughts dropping out from clinical trials (CCTs), (2) how informed they felt before during trial participation, (3) trust in researchers. Methods: We surveyed 110 adult patients who were enrolled by using 15 modified items Medical Communication Competence Scale measuring information exchange relational communication. Retention was measured...
Alzheimer dementia is a complex clinical syndrome that can be defined broadly as an amnestic multidomain dementia. We previously reported human cortical proteins are implicated in To understand the pathologic correlates of these for underlying disease mechanisms, we investigated protein associations with common age-related neuropathologies.
ABSTRACT A novel oxazolidinone for the treatment of Mycobacterium tuberculosis has been developed, but activity contezolid (MRX-I) still needs to be clarified. In this study, we isolated from 48 clinical patients with pulmonary tuberculosis. Roche drug susceptibility tests identified drug-sensitive and 39 drug-resistant M. isolates. Drug assays indicated that MRX-I exhibited anti- against both isolates, an advantage The results also showed was comparable linezolid. IMPORTANCE Currently,...
Oxidative stress refers to the imbalance between production of oxidant species and body’s ability quench them using antioxidants, favoring rise in levels. This leads damage cellular macromolecules such as lipids, DNA, RNA, proteins. The manage oxidative maintain it at an optimum level is crucial for overall health. damage, if left unmitigated, contributes aging process characterized by progressive deterioration physiological functions structures. Understanding mechanisms along with its...
The interrelationship of parkinsonism, Parkinson's disease (PD) and other Alzheimer's (AD) related dementias (ADRD) pathologies is unclear.