A5037958121- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- RNA regulation and disease
- RNA modifications and cancer
- Metalloenzymes and iron-sulfur proteins
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Anesthesia and Sedative Agents
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- PI3K/AKT/mTOR signaling in cancer
- Cancer Genomics and Diagnostics
- Veterinary Pharmacology and Anesthesia
- Breast Cancer Treatment Studies
- Abdominal Surgery and Complications
- Electrolyte and hormonal disorders
- Diabetes Management and Research
- Vascular Tumors and Angiosarcomas
- Anesthesia and Neurotoxicity Research
- Single-cell and spatial transcriptomics
- Cancer and Skin Lesions
- Hippo pathway signaling and YAP/TAZ
Cincinnati Children's Hospital Medical Center
2016-2023
Tata Memorial Hospital
2022-2023
University of Cincinnati
2021-2022
Dr. Rajendra Prasad Government Medical College
2022
Maharshi Dayanand University
2021
King Edward Memorial Hospital and Seth G.S. Medical College
2012
Background Cancer immunotherapy has taken center stage in cancer treatment. However, the current immunotherapies only benefit a small proportion of patients with cancer, necessitating better understanding mechanisms tumor immune evasion and improved strategies. Regulatory T (Treg) cells play an important role maintaining tolerance through inhibiting effector T-cell function. In microenvironment, Treg are used by to counteract cell-mediated suppression. Targeting may thus unleash antitumor...
Abstract Malignant gliomas such as glioblastoma are highly heterogeneous with distinct cells of origin and varied genetic alterations. It remains elusive whether the specific states neural cell lineages differentially susceptible to alterations during malignant transformation. Here, an analysis The Cancer Genome Atlas databases revealed that comutations PTEN TP53 most significantly enriched in human high-grade gliomas. Therefore, we selectively ablated Pten Trp53 different progenitors...
Retroperitoneal liposarcomas are rare malignant tumors known for their slow growth and challenging management, particularly due to substantial size upon diagnosis. This case report highlights a remarkable instance of massive retroperitoneal sarcoma concomitant with synchronous renal cell carcinoma.We 57-year-old male patient huge abdominal mass hampering his daily activities on further investigation, CECT abdomen pelvis revealed large Scarcoma (RPS) occupying entire cavity displacing the...
Introduction Metaplastic breast cancer (MBC) is a rare malignancy that accounts for < 1% of all cancers. The aim this study to evaluate the clinicopathologic characteristics MBC patients treated at tertiary center. Materials and methods In study, authors retrospectively analyzed prospectively maintained data care center in North India between January 2019 July 2022. Results A total 28 MBCs were identified. median age presentation was 47 years (range 27-81 years). Seventeen (60.7%) presented...
This study was designed to evaluate the clinical efficacy of 2 low-dose nebulised drug combinations dexmedetomidine-ketamine and dexmedetomidine-midazolam as a premedication in children scheduled for surgery under general anaesthesia.Sixty classified American Society Anesthesiologists physical status I, aged between 3 10, listed undergo elective surgeries anaesthesia were enrolled this prospective, randomised, double-blind trial. Patients randomly allocated receive approximately 30 minutes...
Background: The cardiovascular implications due to CO2 insufflation during laparoscopic surgeries have been a subject of research. Animal studies reported life threatening increase in serum potassium levels rise intra-abdominal pressure. Methods: Induction 30 patients undergoing laproscopic cholecystectomy was done by giving Thiopentone sodium 5 mg/kg and orotracheal intubation facilitated 0.1 vecuronium bromide. Blood samples for were taken at pre-induction, pre insufflation, every 20...
Abstract Tumor suppressors PTEN and TP53 are the most commonly mutated anti-oncogenes in human gliomas after TERT mutation. 38% 17% of total 4023 samples TCGA show mutations respectively. signaling pathway plays an important role suppression tumor progression negatively regulates PI3 triphosphate levels suppresses AKT/PKB pathways. In-frame missense constitutively activates proliferative give a survival advantage. Mice with conditional mutation neural stem cells directed by hGFAP-Cre develop...
<div>Abstract<p>Malignant gliomas such as glioblastoma are highly heterogeneous with distinct cells of origin and varied genetic alterations. It remains elusive whether the specific states neural cell lineages differentially susceptible to alterations during malignant transformation. Here, an analysis The Cancer Genome Atlas databases revealed that comutations <i>PTEN</i> <i>TP53</i> most significantly enriched in human high-grade gliomas. Therefore, we...
<p>Supplementary figure with legends and supplementary methods</p>
<p>Supplementary figure with legends and supplementary methods</p>
<div>Abstract<p>Malignant gliomas such as glioblastoma are highly heterogeneous with distinct cells of origin and varied genetic alterations. It remains elusive whether the specific states neural cell lineages differentially susceptible to alterations during malignant transformation. Here, an analysis The Cancer Genome Atlas databases revealed that comutations <i>PTEN</i> <i>TP53</i> most significantly enriched in human high-grade gliomas. Therefore, we...
Glioblastoma (GBM) is the most common primary brain cancer in adults and has a poor prognosis.It characterized by high degree of cellular infiltration that leads to tumor recurrence, atypical hyperplasia, necrosis, angiogenesis.Despite aggressive treatment modalities, current therapies are ineffective for GBM.Mouse GBM models not only provide better understanding mechanisms gliomagenesis, but also facilitate drug discovery treating this deadly cancer.A retroviral vector system expresses...
Glioblastomas are malignant brain tumors that carry a poor prognosis. The tumor microenvironment has been identified as an important regulator of growth and may represent novel target for therapy. We have developed mouse models corresponding to two different glioma molecular subtypes, proneural mesenchymal, identify changes in composition between subtypes. performed Drop-Seq on endpoint from the model found associated macrophages microglia most prominent infiltrating microenvironmental...
Abstract Glioblastomas are malignant brain tumors that carry a poor prognosis. The tumor microenvironment has been identified as an important regulator of growth and may represent novel target for therapy. Transcriptional subtypes glioma major source heterogeneity expression in gliomas. Gliomas highly heterogeneous diseases can be classified into different including proneural, classical mesenchymal tumors. We hypothesized will have microenvironmental composition exhibit distinct responses to...
Abstract Glioblastomas are malignant brain tumors that carry a poor prognosis. The tumor microenvironment has been identified as an important regulator of growth and may represent novel target for therapy. We have developed mouse models corresponding to two different glioma molecular subtypes, proneural mesenchymal, identify changes in composition between subtypes. performed Drop-Seq on endpoint from the model found associated macrophages microglia most prominent infiltrating...
Abstract Regulatory T (Treg) cells play an important role in maintaining immune tolerance through inhibiting effector cell function. In the tumor microenvironment, Treg are utilized by to counteract cell-mediated killing. Targeting may thus unleash anti-tumor activity of cells. While systemic depletion can cause excessive responses and subsequent autoimmune diseases, controlled targeting benefit cancer patients. Here we show that cell-specific heterozygous deletion or pharmacological Cdc42...