A5038517660- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Infant Development and Preterm Care
- Congenital Diaphragmatic Hernia Studies
- Birth, Development, and Health
- Congenital Heart Disease Studies
- Respiratory Support and Mechanisms
- Cardiovascular Conditions and Treatments
- Infant Nutrition and Health
- Cardiac Arrhythmias and Treatments
- Neonatal and fetal brain pathology
- Neonatal Health and Biochemistry
- Obstructive Sleep Apnea Research
- Metabolism and Genetic Disorders
- Child and Adolescent Health
- Hemoglobinopathies and Related Disorders
- Infant Health and Development
- Cardiovascular Syncope and Autonomic Disorders
- Testicular diseases and treatments
- Cannabis and Cannabinoid Research
- Patient Safety and Medication Errors
- Adrenal Hormones and Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Receptor Mechanisms and Effects
- Prenatal Substance Exposure Effects
Guangdong Academy of Medical Sciences
2025
Southern Medical University
2025
Guangdong Provincial People's Hospital
2025
National Cheng Kung University Hospital
2009-2024
National Cheng Kung University
1996-2014
University of Manitoba
1997
Northeastern University
1993
VEGF plays a critical role during lung development and is decreased in human infants with bronchopulmonary dysplasia. Inhibition of receptors the newborn rat decreases vascular growth alveolarization causes pulmonary hypertension (PH). Nitric oxide (NO) downstream mediator VEGF, but whether effects impaired signaling are due to NO production unknown. Therefore, we sought determine downregulates endothelial synthase (eNOS) expression developing inhaled (iNO) PH improves after inhibition....
The efficacy of nasal intermittent positive pressure ventilation (NIPPV) in treating apnea prematurity was evaluated. Apneic preterm infants were randomly assigned to receive either NIPPV or continuous airway (NCPAP) for 4 hr when they failed respond conservative therapy. amount reduction apneic spells and bradycardia the two groups after treatment compared. Thirty-four (18 with NIPPV, 16 NCPAP) enrolled. Their birth weights ranged from 590–1,880 g (mean, 1,021 g) gestational ages 25–32...
Abstract Our aim was to develop a machine learning-based predictor for early mortality and severe intraventricular hemorrhage (IVH) in very-low birth weight (VLBW) preterm infants Taiwan. We collected retrospective data from VLBW infants, dividing them into two cohorts: one model development internal validation (Cohort 1, 2016–2021), another external 2, 2022). Primary outcomes included mortality, IVH, poor (a combination of both). Data preprocessing involved 23 variables, with the top four...
The in-hospital length of stay (LOS) among very-low-birth-weight (VLBW, BW < 1500 g) infants is an index for care quality and affects medical resource allocation. We aimed to analyze the LOS VLBW in Taiwan, develop compare performance different prediction models using machine learning (ML) techniques.This retrospective study illustrated data from born between 2016 2018 registered Taiwan Neonatal Network. Among discharged alive, continuous variables (LOS or postmenstrual age, PMA) categorical...
Early postnatal use of dexamethasone has recently been shown to be effective in improving the pulmonary status premature infants with respiratory distress syndrome (RDS). To study effect on inflammatory responses, we studied ten treated and without this treatment. Serial tracheal aspirates were obtained for cell counts, neutrophil total protein concentrations, leukotriene B4 (LTB4) 6-keto prostaglandin (PG)F1α levels before after starting study. Infants dexamethasone-treated group required...
In single channel patch-clamp recordings from freshly dissociated rat corpus striatum (caudate-putamen) neurons, the sulfonylurea drugs tolbutamide and glibenclamide caused a concentration-dependent blockade of K+ that is activated by D2 dopamine receptor agonists. Tolbutamide was about 10-100 times more potent than glibenclamide, rank-order potency opposite to seen at previously described adenosine triphosphate-sensitive channels. The also poorly diazoxide, which known opener However, like...
Bronchopulmonary dysplasia (BPD) has been a critical morbidity in preterm infants. To improve our definition and prediction of BPD is challenging yet indispensable. We aimed to apply machine learning (ML) investigate effective models by using the recently-proposed data-driven predict late respiratory support modalities at 36 weeks' post menstrual age (PMA). collected data on very-low-birth-weight infants born between 2016 2019 from Taiwan Neonatal Network database. Twenty-four attributes...
Abstract Purpose Incorrect dosage was the most common type of medication errors in neonate patients. Different dosing recommendations from reference sources may have contributed to errors. This study assesses compliance rate with antibiotic prescribed for preterm infants a neonatal intensive care unit (NICU). Methods A retrospective using chart review conducted at tertiary medical center university affiliation Taiwan. Study subjects were neonates admitted NICU between 2000 and 2002 least one...
Invasive interventions have been conducted in preterm infants with significant patent ductus arteriosus (PDA) when medical treatment has failed, and methods of invasive intervention reported. Surgical ligation via lateral thoracotomy a well-established procedure for decades. Recently, transcatheter occlusion safely feasibly applied to the premature population. However, little research on benefits very-low-birth-weight (VLBW) compared surgical ligation. This study techniques VLBW terms...
Hour-specific bilirubin nomogram has been recommended to predict postdischarge hyperbilirubinemia in newborns. However, it may not be applicable Taiwan due ethnic differences. The aim of this study was construct a 12-h specific transcutaneous (TCB) newborns for clinical reference.We prospectively enrolled full term or late preterm neonates born tertiary care hospital between October 2013 and July 2014. exclusion criteria included chromosome anomaly, glucose-6-phosphate dehydrogenase...
Abstract Advances in perinatal care have led to the increased survival of preterm infants with subsequent neonatal morbidities, such as retinopathy prematurity (ROP). This study aims compare differences healthcare systems, resources, and clinical practice concerning ROP Asia review current literature. An on-line survey at institutional level was sent directors 336 intensive units (NICU) 8 collaborating national networks through Asian Neonatal Network Collaboration (AsianNeo). screening...
BackgroundTo study the distribution of birthplaces very-low-birth-weight (VLBW) infants and examine whether delivery at different levels hospital affects neonatal infant mortality.MethodsThis population-based cohort was retrieved from Taiwan Maternal Child Health Database. Livebirth singleton VLBW born between 2011 2014, with BW 500 1499 g gestational age ≥22 weeks were enrolled. The main outcomes risk-adjusted odds ratios (aOR) mortality by birthplace, which categorized as medical center...
Objectives The management of patent ductus arteriosus (PDA) is a critical concern in premature infants, and different hospitals may have varying treatment policies, fluid strategies, incubator humidity. Asian Neonatal Network Collaboration (AsianNeo) collected data on prematurity care details from across countries. aim this study was to provide survey the current practices PDA infants Methods AsianNeo performed cross-sectional international questionnaire 2022 assess human physical resources...
This study aimed to explore the relationship between trajectories of body weight (BW)