A5006304513- CAR-T cell therapy research
- Gut microbiota and health
- Oral health in cancer treatment
- Nutrition and Health in Aging
- Hematopoietic Stem Cell Transplantation
- CNS Lymphoma Diagnosis and Treatment
- Central Venous Catheters and Hemodialysis
- Acute Lymphoblastic Leukemia research
- Retinoids in leukemia and cellular processes
- Glioma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Cancer Treatment and Pharmacology
- Asthma and respiratory diseases
- Virus-based gene therapy research
- Silk-based biomaterials and applications
- Public Health in Brazil
- Invertebrate Immune Response Mechanisms
- Lymphoma Diagnosis and Treatment
- Acute Kidney Injury Research
- Renal Transplantation Outcomes and Treatments
- Venous Thromboembolism Diagnosis and Management
- Safe Handling of Antineoplastic Drugs
- Synthetic Organic Chemistry Methods
- Diversity and Career in Medicine
- Advanced Biosensing Techniques and Applications
Michigan Medicine
2019-2024
Michigan United
2024
University of Michigan
2017-2024
U-M Rogel Cancer Center
2023
Denison University
2013
University of Kentucky
2012
Background The risk of peripherally inserted central catheter (PICC)‐related complications in patients hospitalized with solid tumors remains unclear. Existing studies are limited by single‐center, outpatient designs and include heterogenous patients. Methods A retrospective cohort study was designed included adult organ cancers who were admitted to a general medicine ward or intensive care unit received PICC. Data collected from November 2013 December 2019 at 50 Michigan hospitals. Major...
Abstract Evaluation of the impact dietary intervention on gastrointestinal microbiota and metabolites after allogeneic hematopoietic stem cell transplantation (HCT) is lacking. We conducted a feasibility study as first two-phase trial. Ten adults received resistant potato starch (RPS) daily from day −7 to 100. The primary objective was test RPS its effect intestinal microbiome metabolites, including short-chain fatty acid butyrate. Feasibility met preset goal 60% or more, adhering 70% more...
Introduction Lymphodepleting chemotherapy (LDC) is critical to CAR T-cell expansion and efficacy. Despite this, there not a consensus in the literature regarding optimal LDC regimen, including dose frequency. Methods We retrospectively reviewed consecutive patients at single institution that received prior treatment with CD19 directed products axicabtagene ciloleucel tisagenlecleucel. Patients treated our center fludarabine 30 mg/m 2 cyclophosphamide 500 for 3 days May 2019. After this...
Summary Intravascular large B‐cell lymphoma ( IVLBCL ) is a rare entity, with generally aggressive course that may vary based on geographic presentation. While United States US registry study showed relatively good outcomes , clinicopathological and treatment data were unavailable. We performed detailed retrospective review of cases identified at 8 medical centres, to improve understanding inform management. compiled retrieved via an Institutional Review Board‐approved from 1999 2015 nine...
Inhalation of tumor necrosis factor-alpha (TNF-α), a proinflammatory cytokine, induces airway hyperresponsiveness, and the underlying mechanism is not fully understood. Hypersensitivity vagal bronchopulmonary C-fiber afferents known to contribute hyperresponsiveness during an inflammatory reaction. Because activation these can elicit pulmonary chemoreflexes, this study was designed determine if pretreatment with TNF-α induced inflammation enhanced chemoreflex sensitivity in anesthetized...
All-trans retinoic acid (ATRA) serves as the backbone of management patients with acute promyelocytic leukemia (APL), guidelines recommending initiation ATRA soon APL is suspected. As a regional referral center for leukemia, those who are suspected having often transferred to our facility. However, many referring centers unable initiate treatment using ATRA. We conducted an exploratory analysis clinical availability and factors limiting access this critical drug.The United States was divided...
The transition of Drosophila third instar larvae from feeding, photo-phobic foragers to non-feeding, photo-neutral wanderers is a classic behavioral switch that precedes pupariation. neuronal network responsible for this behavior has recently begun be defined. Previous genetic analyses have identified signaling components food and light sensory inputs neuropeptide hormonal outputs as being critical the forager wanderer transition. Trio Rho-Guanine Nucleotide Exchange Factor integrated into...
TNFα is a proinflammatory cytokine, and plays an important role in the pathogenesis of allergic asthma. A recent study our lab has demonstrated that prolonged (24–48 h) treatment with increased Ca 2+ influx evoked by TRPV1 activators vagal pulmonary sensory neurons (Am J Physiol 299: 483–492, 2010). The present was carried out to test acute effect transient on sensitivity isolated rat neurons. Our results showed: 1) brief low concentration (1.44 nM; 9 min) induced biphasic hypersensitivity...