A5019575613- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Acute Myeloid Leukemia Research
- Healthcare Policy and Management
- Medication Adherence and Compliance
- Cardiac electrophysiology and arrhythmias
- Hemoglobinopathies and Related Disorders
- Cardiovascular Function and Risk Factors
- Palliative Care and End-of-Life Issues
- Primary Care and Health Outcomes
- Global Cancer Incidence and Screening
- Metabolism, Diabetes, and Cancer
- Multiple and Secondary Primary Cancers
- Global Health Care Issues
- Cancer survivorship and care
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Pharmaceutical Economics and Policy
- COVID-19 and healthcare impacts
- Pharmaceutical Practices and Patient Outcomes
- Chronic Myeloid Leukemia Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
National Cancer Institute
2015-2024
Yale University
2014-2022
Yale Cancer Center
2015-2022
Yale New Haven Health System
2015-2021
National Cancer Institute
2021
University of New England
2008-2021
University of New Haven
2019
Yale New Haven Hospital
2019
Brown University
2017-2018
Rhode Island Hospital
2017-2018
To estimate the prevalence of financial hardship associated with cancer in United States and identify characteristics survivors hardship.We identified 1,202 adult diagnosed or treated at ≥ 18 years age from 2011 Medical Expenditure Panel Survey Experiences With Cancer questionnaire. Material was measured by ever (1) borrowing money going into debt, (2) filing for bankruptcy, (3) being unable to cover one's share medical care costs, (4) making other sacrifices because cancer, its treatment,...
Cellular constituents of heart muscle contain both constitutive and inducible nitric oxide (NO) signaling pathways that modulate the contractile properties cardiac myocytes. The identities NO synthase (iNOS) isoform(s) expressed in muscle, specific cell types expressing iNOS activity, remain poorly characterized. We amplified a 217-base pair cDNA by reverse transcriptase-polymerase chain reaction from primary cultures inflammatory cytokine-pretreated adult rat ventricular myocytes (ARVM) was...
Objectives To use the most recently available population‐based data to estimate potentially inappropriate medication ( PIM ) prevalence under 2012 update of Beers list s and provide a benchmark from which measure future changes. Design Retrospective cohort study using nationally representative data. Setting 2006–2010 Medical Expenditure Panel Survey MEPS ). Participants Community‐dwelling sample U.S. older adults (N = 18,475). Measurements The updated criteria were operationalized,...
Platinum-doublet chemotherapy regimens have been shown to extend survival in fit patients with advanced non-small-cell lung cancer (AdvNSCLC). This study extends recent population-based analyses focusing on treatment and benefit from use of platinum-doublet therapy, addressing the role performance status (PS).Patients >or= 66 years AdvNSCLC incident 1997 2002 were identified SEER-Medicare. Multivariate models examined tumor patient characteristics associated receipt any compared single-agent...
To determine whether diabetes-induced cardiac dysfunction is due to contractile at the single-cell level, mechanical properties and Ca2+ transients were evaluated in ventricular myocytes isolated from diabetic rats. Rats made by injection with streptozotocin killed either 4-6 days or 8 wk after treatment. Shortening relengthening (twitch) a high-resolution (120-Hz) video-based edge-detection system during electrical stimulation between 0.1 5 Hz. A separate cohort of was loaded fura 2 assess...
Abstract BACKGROUND: There is increasing concern regarding the financial burden of care on cancer patients and their families. Medicare beneficiaries often have extensive comorbidities limited resources, may face substantial cost sharing even with supplemental coverage. In current study, authors examined out‐of‐pocket (OOP) spending relative to income for cancer. METHODS: This retrospective, observational study pooled data 1997 through 2007 from Current Beneficiary Survey linked claims....
Purpose To examine change in the percent uninsured and early-stage diagnosis among nonelderly patients with newly diagnosed cancer after Affordable Care Act (ACA). Patients Methods By using National Cancer Data Base, we estimated absolute (APC) relative age 18 to 64 years between 2011 third quarter of 2013 (pre-ACA implementation) second fourth 2014 (post-ACA) Medicaid expansion nonexpansion states by family income level. We also examined demographics-adjusted difference differences APC...
Abstract Background The current study examined medical financial hardship in cancer survivors and those without a history the United States. Methods 2013 to 2016 National Health Interview Survey was used identify (stratified by ages 18‐49 years [1424 survivors], 50‐64 [2916 ≥65 [6014 survivors]) individuals (ages 18‐64 [66,951 individuals], [31,741 [25,744 individuals]). Medical categorized into 3 domains: 1) material (eg, problems paying bills); 2) psychological worrying about 3) behavioral...
Abstract The hypomethylating agents (HMAs) azacitidine and decitabine have been the de facto standard of care for patients with acute myeloid leukemia (AML) who are unfit intensive therapy. Using Surveillance, Epidemiology, End Results-Medicare linked database, we identified 2263 older adults (age ≥66 years) diagnosed AML during 2005-2015 received a first-line HMA; 1154 (51%) azacitidine, 1109 (49%) decitabine. Median survival from diagnosis was 7.1 8.2 months (P < .01) azacitidine-...
Abstract Aims The glucose-driven enzymatic modification of myocardial proteins by the sugar moiety, β-N-acetylglucosamine (O-GlcNAc), is increased in pre-clinical models diabetes, implicating protein O-GlcNAc diabetes-induced heart failure. Our aim was to specifically examine cardiac manipulation two regulatory enzymes this process on phenotype, presence and absence utilising cardiac-targeted recombinant-adeno-associated viral-vector-6 (rAAV6)-mediated gene delivery. Methods results In human...
Low-osmolality contrast agents produce fewer hemodynamic and electrophysiologic alterations during cardiac angiography, but they are 20 times more expensive than high-osmolality agents. In a randomized, double-blind trial comparing nonionic, low-osmolality agent (Omnipaque 350) with that does not avidly bind calcium (Hypaque 76) in 505 patients undergoing we determined the incidence of minor, mild, moderate, severe adverse reactions, identified risk factors for such evaluated cost...
Increased levels of O-linked attachment N-acetylglucosamine ( O-GlcNAc) on nucleocytoplasmic proteins are implicated in the development diabetic cardiomyopathy and regulated by O-GlcNAc transferase (OGT) expression its substrate UDP-GlcNAc. Therefore, goal this study was to determine whether diabetes Zucker fatty (ZDF) rat, a model Type 2 diabetes, results defects cardiomyocyte mechanical function and, if so, is associated with increased OGT expression. Six-week-old ZDF rats were...
There is limited evidence from nationally representative samples about changes in prescription drug use for financial reasons among cancer survivors the United States.The 2011 to 2014 National Health Interview Survey was used identify adults who reported ever having been told they had (cancer survivors; n = 8931) and individuals without a history (n 126,287). Measures of included: 1) skipping medication doses, 2) taking less medicine, 3) delaying filling prescription, 4) asking doctor lower...
Purpose Little is known about the patterns and predictors of use end-of-life health care among patients with acute myeloid leukemia (AML). End-of-life particularly relevant for older adults AML because their poor prognosis. Methods We performed a population-based, retrospective cohort study who were ≥ 66 years age at diagnosis diagnosed during period from 1999 to 2011 died before December 31, 2012. Medicare claims used assess hospice aggressive treatment. Predictors these end points...
Objective To examine the determinants of potentially inappropriate medication ( PIM ) use. Data Sources/Study Setting U.S. nationally representative data on n = 16,588) noninstitutionalized older adults (age ≥65) with drug use from 2006–2010 Medical Expenditure Panel Survey. Study Design We operationalized 2012 Beers Criteria to identify during year, and we examined associations individual‐level characteristics hypothesized be quality enabling or related need complexity. Principal Findings...
Summary The hypomethylating agents ( HMA s) azacitidine and decitabine are both approved for treatment of myelodysplastic syndromes MDS ) in the USA . In Europe, is not due to lack survival advantage randomized trials. two drugs have been compared clinical We identified patients diagnosed with between 2004 2011 from Surveillance, Epidemiology, End Results SEER )‐Medicare linked database who received ≥ 10 doses either estimated initiation Kaplan–Meier methods used multivariate Cox...
To model with greater fidelity the electromechanical function of freshly isolated heart muscle cells in primary culture, we describe a technique for continual electrical stimulation adult myocytes at physiological frequencies several days. A reusable plastic cover was constructed to fit standard, disposable 175-cm2 tissue culture flasks and hold parallel graphite electrodes along long axis each flask, which treated uniform electric field that resulted capture efficiency ventricular 75–80%....