A5018368098- Seismic Waves and Analysis
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Methane Hydrates and Related Phenomena
- Geophysics and Gravity Measurements
- Nanoparticle-Based Drug Delivery
- DNA and Nucleic Acid Chemistry
- Dendrimers and Hyperbranched Polymers
- Biosensors and Analytical Detection
- Nanoplatforms for cancer theranostics
- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- Seismology and Earthquake Studies
- Microbial Community Ecology and Physiology
- Earthquake Detection and Analysis
- Mitochondrial Function and Pathology
- Electrochemical Analysis and Applications
- Microbial Fuel Cells and Bioremediation
- Glycosylation and Glycoproteins Research
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Membrane Separation Technologies
- Advanced Polymer Synthesis and Characterization
- Ionosphere and magnetosphere dynamics
- Metabolism and Genetic Disorders
University of Illinois Urbana-Champaign
2019-2025
Rice University
2025
The University of Texas at Austin
2021-2025
Shanghai Jiao Tong University
2016-2020
Metal Matrix Cast Composites (United States)
2016-2019
State Key Laboratory of Metal Matrix Composites
2016-2019
Sichuan University
2012
Beyond its extraordinary genome editing ability, the CRISPR-Cas systems have opened a new era of biosensing applications due to high base resolution and isothermal signal amplification. However, reported sensors are largely only used for detection nucleic acids with limited application non-nucleic-acid targets. To realize full potential broaden their quantitation targets, we herein report CRISPR-Cas12a that regulated by functional DNA (fDNA) molecules such as aptamers DNAzymes selective...
Abstract Functional siRNAs are employed as cross‐linkers to direct the self‐assembly of DNA‐grafted polycaprolactone (DNA‐ g ‐PCL) brushes form spherical and nanosized hydrogels via nucleic acid hybridization in which small interfering RNAs (siRNAs) fully embedded protected for systemic delivery. Owing existence multivalent mutual crosslinking events inside, crosslinked nanogels with tunable size exhibit not only good thermostability, but also remarkable physiological stability that can...
Abstract Based on their structural similarity to natural nucleobases, nucleoside analogue therapeutics were integrated into DNA strands through conventional solid‐phase synthesis. By elaborately designing sequences, floxuridine‐integrated synthesized and self‐assembled well‐defined polyhedra with definite drug‐loading ratios as well tunable size morphology. As a novel drug delivery system, these drug‐containing could ideally mimic the Trojan Horse deliver chemotherapeutics tumor cells fight...
Combinatorial chemo and gene therapy provides a promising way to cure drug-resistant cancer, since the codelivered functional nucleic acids can regulate drug resistance genes, thus restoring sensitivity of cells chemotherapeutics. However, dramatic chemical physical differences between chemotherapeutics greatly hinder design construction an ideal delivery system (DDS) achieve synergistic antitumor effects. Herein, we report novel approach synthesize nanosized DDS using drug-integrated DNA...
DNA aptamers have been widely used as biosensors for detecting a variety of targets. Despite decades success, they not applied to monitor any targets in plants, even though plants are major platform providing oxygen, food, and sustainable products ranging from energy fuels chemicals, high-value such pharmaceuticals. A barrier progress is lack efficient methods deliver into plant cells. We herein report thiol-mediated uptake method that more efficiently delivers Arabidopsis tobacco leaf cells...
Tumor-targeted drug delivery with simultaneous cancer imaging is highly desirable for personalized medicine. Herein, we report a supramolecular approach to design promising class of multifunctional nanoparticles based on molecular recognition nucleobases, which combine excellent tumor-targeting capability via aptamer, controlled release, and efficient fluorescent cancer-specific therapy. First, an amphiphilic prodrug dioleoyl clofarabine was self-assembled into micellar hydrophilic...
Herein, we report the self-assembled floxuridine-containing DNA and RNA nanogels with a precise drug loading ratio as effective delivery systems.
Herein, we construct a structure-switchable gemcitabine (Ge)-containing DNA nanogel that can respond to the intracellular acidic environment, subsequently facilitating chemodrug release inside cells. Based on structural similarity between Ge and deoxycytidine (dC), dC nucleotides in component strands used for assembly are fully replaced by during their synthesis. By changing designed sequences, two Ge-containing Y-shaped motifs with different sticky ends first assembled then associated...
Nano drug delivery systems have emerged as promising candidates for cancer therapy, whereas their uncertainly complete elimination from the body within specific timescales restricts clinical translation. Compared with hepatic clearance of nanoparticles, renal excretion small molecules is preferred to minimize agent-induced toxicity. Herein, we construct in vivo renal-clearable which are self-assembled amphiphilic holding capabilities magnetic resonance imaging (MRI) and chemotherapy. The...
Abstract Based on their structural similarity to natural nucleobases, nucleoside analogue therapeutics were integrated into DNA strands through conventional solid‐phase synthesis. By elaborately designing sequences, floxuridine‐integrated synthesized and self‐assembled well‐defined polyhedra with definite drug‐loading ratios as well tunable size morphology. As a novel drug delivery system, these drug‐containing could ideally mimic the Trojan Horse deliver chemotherapeutics tumor cells fight...
Abstract Small molecule nanodrugs consisting of pure drugs, drug‐drug dimers, conjugates, or drug derivatives could realize delivery by themselves without the aid carriers, which have received abundant attention in recent decades. Avoiding use additional yielded small hold following advantages: (a) high loading capacities (some them even reach up to 100%); (b) precise and tunable ration; (c) no carrier‐induced long‐term toxicity. The past decade has witnessed rapid growth advancements this...
A fluoride sensor based on riboswitch-regulated transcription coupled with Cas13a can detect in water a portable fluorometer. This expands nuclei acid sensors to an anion, high sensitivity and selectivity against other common anions.
Detecting Coenzyme A (CoA) in cells is vital for understanding its role metabolism. DNA aptamers, though widely used monitoring many other molecules, have not been effective CoA...
Abstract Functional siRNAs are employed as cross‐linkers to direct the self‐assembly of DNA‐grafted polycaprolactone (DNA‐ g ‐PCL) brushes form spherical and nanosized hydrogels via nucleic acid hybridization in which small interfering RNAs (siRNAs) fully embedded protected for systemic delivery. Owing existence multivalent mutual crosslinking events inside, crosslinked nanogels with tunable size exhibit not only good thermostability, but also remarkable physiological stability that can...
This review summarizes the main barriers of gene delivery, control properties and recent progress hyperbranched polymers for delivery.