A5045761229- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- SARS-CoV-2 and COVID-19 Research
- Metabolism and Genetic Disorders
- Folate and B Vitamins Research
- Adipokines, Inflammation, and Metabolic Diseases
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- Clinical Laboratory Practices and Quality Control
- Acute Myocardial Infarction Research
- Renal function and acid-base balance
- Cytokine Signaling Pathways and Interactions
- Cancer, Lipids, and Metabolism
- Medical Research and Treatments
- Cardiac Imaging and Diagnostics
- Electrolyte and hormonal disorders
- Cardiovascular Function and Risk Factors
- Hemoglobinopathies and Related Disorders
- Cancer Immunotherapy and Biomarkers
- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- Disaster Response and Management
- Esophageal and GI Pathology
- Health Systems, Economic Evaluations, Quality of Life
- Viral Infections and Outbreaks Research
The University of Texas Southwestern Medical Center
2020-2025
Children's Medical Center
2022-2025
Cook Children's Health Care System
2024
Changsha Central Hospital
2024
University of South China
2024
Regeneron (United States)
2022-2024
First Affiliated Hospital of Anhui Medical University
2021-2022
Anhui Medical University
2021-2022
Shenzhen Third People’s Hospital
2022
Baylor College of Medicine
2017-2021
The sum of eicosapentaenoic acid (EPA, 20:5 omega3) and docosahexaenoic (DHA, 22:6 in erythrocyte membranes, termed the omega-3 index, can indicate suboptimal intake fatty acids, a risk factor for cardiovascular disease (CVD). To study effects supplementation, we investigated rate incorporation clearance these acids membranes plasma after supplements.Twenty participants received supplementation with either fish oil (1296 mg EPA + 864 DHA/day) or flaxseed (3510 alpha-linolenic 900 linoleic...
Objective— We aimed to examine associations of lipoprotein(a) (Lp(a)) concentrations with coronary heart disease (CHD) and determine whether current Lp(a) clinical laboratory cut points identify risk incidence in 4 races/ethnicities the Multi-Ethnic Study Atherosclerosis (MESA). Approach Results— A subcohort 1323 black, 1677 white, 548 Chinese American, 1044 Hispanic MESA participants were followed up during a mean 8.5-year period which 235 incident CHD events recorded. mass measured using...
Lung-transplant (LT) recipients are at high risk for COVID-19 due to immunosuppression and respiratory tropism of SARS-CoV-2. The information on the effect mRNA vaccines elicit immunogenic responses after a two-dose (2D) regimen in LT is sparse. Thus, we assessed Pfizer-BioNTech Moderna vaccines' 2D anti-spike immunocompromised recipients.
The interleukin-6 (IL-6) family cytokines signal through gp130 receptor homodimerization or heterodimerization with a second signaling and play crucial roles in various cellular processes. We determined cryo–electron microscopy structures of five complexes this family, containing full ectodomains bound to their respective ligands ciliary neurotrophic factor, cardiotrophin-like cytokine factor 1 (CLCF1), leukemia inhibitory IL-27, IL-6. Our collectively reveal similarities differences the...
Lipoprotein(a) [Lp(a)] is a risk factor for calcific aortic valve disease (CAVD) but has not been evaluated across multiple races/ethnicities. This study aimed to determine whether Lp(a) cutoff values used in clinical laboratories assess of cardiovascular identify subclinical CAVD and its severity significant relations are observed race/ethnicity.Lp(a) concentrations were measured using turbidimetric immunoassay, was by quantifying calcification (AVC) through computed tomographic scanning...
Abstract The continuous administration of compound danshen dripping pills (CDDP) showed good efficacy in relieving myocardial ischemia clinically. To probe the underlying mechanism, metabolic features were evaluated a rat model acute induced by isoproterenol (ISO) and administrated with CDDP using metabolomics platform. Our data revealed that ISO-induced animal obvious injury, decreased energy production, marked change metabolomic patterns plasma heart tissue. pretreatment increased...
Many laboratories utilize direct LDL-C assays as part of a reflex protocol at TG >400 mg/dL. Despite the cost associated with testing in place freely available calculations, some still prefer assay lipid panel. This approach is followed regardless patient's or levels. However, Miller et al. have shown biases assays, often leading to overestimating dyslipidemia patients (7). Importantly, their analytical performance current context potent lipid-lowering therapies and stringent target levels...
Abstract Background The accurate measurement of blood lipids and lipoproteins is crucial for the clinical management atherosclerotic disease risk. Despite progress in standardization, there are still significant variations pre-analytical requirements, methods, nomenclature, reporting work flows. Content guidance document aims to improve standardization lipid testing It provides recommendations components panel, fasting results, specific non-high-density lipoprotein cholesterol (non-HDL-C),...
A number of lipoprotein(a) [Lp(a)] analytical techniques are available that quantify distinct particle components, yet their clinical efficacy has not been comprehensively evaluated. This study determined whether Lp(a) mass [Lp(a)-M], cholesterol content [Lp(a)-C], and concentration [Lp(a)-P] differentially discriminated risk calcific aortic valve disease (CAVD) or incident coronary heart (CHD) among 4679 participants the Multi-Ethnic Study Atherosclerosis (MESA).Lp(a)-M, Lp(a)-C, Lp(a)-P...
Laboratory test in transport is a critical component of patient care, and capillary blood preferred sample type particularly children. This study evaluated the performance testing on epoc Point Care Blood Analysis System (Alere Inc). Ten fresh venous samples was tested system under mode. Correlation with GEM 4000 (Instrumentation Laboratory) examined for Na+, K+, Cl-, Ca2+, glucose, lactate, hematocrit, hemoglobin, pO2, pCO2, pH, correlation serum Vitros 5600 (Ortho Clinical Diagnostics)...
Abstract The immunological effectiveness of SARS-CoV-2 mRNA vaccines in lung transplant (LT) recipients is largely unknown. Thus, we assessed the effect Pfizer-BioNTech and Moderna vaccines’ two-dose (2D) regimen on humoral responses immunocompromised recipients. About 25% (18/73) uninfected-LT patients generated positive spike-IgG response following 2D vaccines, with 36% (9/25) cohort only 19% (9/48) Pfizer cohort. LT elicited significantly lesser median IgG SP (1.7 AU/mL, 95% CI: 0.6-7.5...
We aimed to study the clinical utility of serum lipoprotein-associated phospholipase A2 (Lp-PLA2) in acute ischemic stroke (AIS) with cerebral artery stenosis (CAS). included 200 AIS patients and 90 healthy controls this study. were classified into three subgroups depending on severity CAS. They also based stability carotid plaques. Spearman correlation analysis was performed determine relationship between level Lp-PLA2 neurologic injury. Binary logistic regression independent risk factors...
This study compared small dense low-density lipoprotein cholesterol (sdLDL-C) with apolipoprotein B (apo B), and particles (LDL-P) in predicting CHD risk generally healthy adults normal fasting glucose (NFG).