Insulin resistance is tightly related to cognition; however, the causal association between them remains a matter of debate. Our investigation aims establish relationship and direction insulin cognition, while also quantifying mediating role brain cortical structure in this association. The publicly available data sources for (fasting insulin, homeostasis model assessment beta-cell function resistance, proinsulin), structure, cognitive phenotypes (visual memory, reaction time) were obtained...

Abnormal structures in the cortical and subcortical regions have been identified vascular cognition impairment (SVCI). However, little is known about functional alterations SVCI, no study refers to connectivity prefrontal this context. The medial cortex (MPFC) an important region of executive network default mode network, thalamus plays vital roles mediating or modulating these two networks. To investigate both thalamus- MPFC-related as well its relationship with 32 SVCI patients 23 control...

White matter hyperintensities (WMHs) of presumed vascular origin are one the most important neuroimaging markers cerebral small vessel disease (CSVD), which closely associated with cognitive impairment. The aim this study was to elucidate pathogenesis WMHs from perspective inflammation and hypoperfusion mechanisms. A total 65 patients healthy controls were enrolled in study. Inflammatory measurements [hypersensitive C-reactive protein (hsCRP) lipoprotein-associated phospholipase A2...

To investigate the topological properties of functional connectivity and their relationships with cognition impairment in subcortical vascular cognitive (SVCI) patients, resting-state fMRI graph theory approaches were employed 23 SVCI patients 20 healthy controls. Functional between 90 brain regions was estimated using bivariate correlation analysis thresholded to construct a set undirected graphs. Moreover, all them subjected battery assessment, correlations metrics performance further...

Gait disturbances are important clinical features of cerebral small vessel disease (CSVD) that increase the risk falls and disability. Brain structural alterations gait in CSVD patients have been well demonstrated. However, intrinsic resting function patterns with disorders remain largely unknown. Fifty-eight were enrolled our studies categorized into disorder group (CSVD-GD, n = 29) no-gait (CSVD-NGD, based on a examination. was quantitatively assessed Timed Up Go test intelligent device...

Background: The relationship and mechanisms between body mass index (BMI) cognition are complex inconclusive. Additionally, the role of neuronal calcium dysfunction, reflected by cerebrospinal fluid (CSF) Visinin-like protein 1 (VILIP-1), in linked with BMI Alzheimer's disease (AD) has not been investigated. Objective: To investigate CSF VILIP-1, BMI, AD pathologies non-demented elderly at early stages AD. Methods: Baseline core biomarkers (amyloid-β 42 [Aβ ], phosphorylated tau [P-tau],...

Metabolic syndrome (MetS) combined with cerebral small vessel disease (CSVD) is associated cognitive dysfunction. However, the underlying mechanisms remain poorly understood. This study investigated roles of brain perfusion and gray matter volume (GMV) in dysfunction patients MetS CSVD (MetS-CSVD). enrolled 180 86 healthy controls (HCs). Patients were categorized into without (MetS-NCSVD) (n = 58) (MetS-CSVD) 122) groups. All participants underwent laboratory tests, neuropsychological...

Recent small subcortical infarcts (RSSIs) have emerged as a growing public health concern due to their poor long-term clinical outcomes. This study aimed investigate the associations between atherogenic index of plasma (AIP), systemic immune-inflammation (SII), and inflammation response (SIRI) with occurrence recurrence RSSIs. Three hundred forty-two patients RSSIs who met eligibility criteria were included in cross-sectional analysis. Comprehensive demographic, laboratory, neuroimaging data...

Background: White matter hyperintensities (WMHs) are common neuroimaging markers of cerebral small vessel disease (CSVD) and strongly associated with cognitive impairment. While hypoperfusion neuroinflammation recognized as major contributors to WMH pathology, the interplay between inflammatory biomarkers blood flow (CBF) remains poorly understood. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2), a marker microglial activation, may play dual role in vascular dysfunction....

Abstract Objective This study aimed to explore the relationship between white matter hyperintensities (WMHs) and cognitive impairment related metabolic syndrome (MetS) underlying neural network mechanisms. Methods cross‐sectional included 50 participants with MetS WMHs (MetS‐WMHs), 45 without WMHs, control participants. All underwent resting‐state functional magnetic resonance imaging a detailed evaluation. A graph theory analysis based on was conducted calculate properties. mediation...

The primary manifestations of Alzheimer's disease (AD) include cognitive decline and brain gray matter volume (GMV) atrophy. Recent studies have found that plasma phosphorylated-tau (p-tau) concentrations perform better in diagnosing, differentiating, monitoring the progression AD. However, correlation between p-tau, GMV, cognition remains unclear.To investigate whether GMV plays a mediating role association p-tau cognition.In total, 99 participants (47 patients with AD 52 cognitively...

Abstract Acute onset neurological symptoms evoked by traumatic, surgical, or emotional events in Wilson disease (WD) have never been reported and its clinical characteristics are unclear. We aimed to summarize the of a special WD whose acutely developed after events. Retrospective pilot study. Thirty-one patients who had acute symptom as an initial presentation new hepatic mild trauma, surgery, were retrospectively studied. All followed for half 1 year regular anti-copper treatment. The...

The methylenetetrahydrofolate reductase (MTHFR) gene has been associated with Alzheimer's disease (AD) pathogenesis. Amnestic mild cognitive impairment (aMCI) represents a prodromal stage of dementia and involves high risk progression into AD. Although the effects apolipoprotein E (APOE) on structural alterations in aMCI have widely investigated, MTHFR C677T interaction × APOE genotypes gray matter atrophy remain largely unknown. In present study, 60 patients 30 healthy controls were...

We aimed to study the clinical utility of serum lipoprotein-associated phospholipase A2 (Lp-PLA2) in acute ischemic stroke (AIS) with cerebral artery stenosis (CAS). included 200 AIS patients and 90 healthy controls this study. were classified into three subgroups depending on severity CAS. They also based stability carotid plaques. Spearman correlation analysis was performed determine relationship between level Lp-PLA2 neurologic injury. Binary logistic regression independent risk factors...

A headache circumscribed in a line-shaped area but not confined to the territory of one particular nerve had ever been described Epicrania Fugax (EF) which head pain is moving and ultrashort. In 25-month period from Feb 2012 Mar 2014, we encountered 12 patients with paroxysmal motionless restricted linear trajectory. The trajectory was similar that EF, its all other features obviously different those EF. We named this distinctive undescribed type (LH). detailed clinical feature obtained...

Purpose This study aimed to investigate the dynamic functional connectivity (DFC) pattern in cerebral small vessel disease (CSVD) and explore relationships between DFC temporal properties cognitive impairment CSVD. Methods Functional data were collected from 67 CSVD patients, including 35 patients with subcortical vascular (SVCI) 32 cognitively unimpaired (CU) as well healthy controls (HCs). The estimated by k - means clustering analysis. strength analysis was used regional alterations HCs....

The clinical data of safety and efficacy a combined treatment with dimercaptosuccinic acid (DMSA) Zinc 2 years' follow-up in 60 neurological Wilson's disease (WD) patients was retrospectively analyzed. All the included present study were newly diagnosed initialized D-penicillamine (DPA) but found to have either deterioration or allergy, their switched DMSA Zinc. Fifty-one (85%) had symptoms improved 1 years after treatment, 7 (11.67%) experienced stable condition, (3.33%) suffered symptoms....

Background: The hippocampus consists of histologically and functionally distinct subfields, which shows differential vulnerabilities to Alzheimer’s disease (AD)-associated pathological changes. Objective: To investigate the atrophy patterns main hippocampal subfields in patients with mild cognitive impairment (MCI) AD relationships among subfield volumes, plasma biomarkers performance. Methods: This cross-sectional study included 119 stratified into three categories: normal cognition (CN; N...

We aimed to examine changes in serum bilirubin and uric acid (ua) levels subcortical ischemic vascular disease (Sivd). addition, we investigated if altered ua correlate with the subtypes of Sivd as well severity leukoaraiosis (la).this cross-sectional study included 1098 consecutive patients slight symptoms, such dizziness, vertigo etc. according magnetic resonance imaging (Mri) appearances, they were divided into either group or controls (Cn), was further grouped lacunar infarction (li) la...