A5079725786- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Ion channel regulation and function
- Potassium and Related Disorders
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Transplantation: Methods and Outcomes
- Electrochemical Analysis and Applications
- S100 Proteins and Annexins
- Organ Transplantation Techniques and Outcomes
- Renal function and acid-base balance
- Renal Transplantation Outcomes and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ultrasound and Hyperthermia Applications
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Analytical Chemistry and Sensors
- Renal Diseases and Glomerulopathies
- Acute Ischemic Stroke Management
- Mast cells and histamine
- Vitamin C and Antioxidants Research
- Connexins and lens biology
- Sex and Gender in Healthcare
Columbia University
2017-2024
University of Mississippi
2021-2024
University of Mississippi Medical Center
2021-2022
Jackson Memorial Hospital
2021-2022
Emory University Hospital
2021
University of Michigan–Ann Arbor
2011-2018
Brown University
2018
West German Heart and Vascular Center Essen
2018
The University of Tokyo
2018
McGill University
2018
Little is known about the mechanisms underlying transition from paroxysmal to persistent atrial fibrillation (AF). In an ovine model of long-standing AF we tested hypothesis that rate electric and structural remodeling, assessed by dominant frequency (DF) changes, determines time at which becomes persistent.Self-sustained was induced tachypacing. Seven sheep were euthanized 11.5±2.3 days after without reversal sinus rhythm; 7 341.3±16.7 AF. sham-operated animals in rhythm for 1 year. DF...
Atrial dilatation and myocardial stretch are strongly associated with atrial fibrillation (AF). However, the mechanisms by which three-dimensional (3D) architecture heterogeneous contribute to AF perpetuation incompletely understood. We compared dynamics during stretch-related (pressure: 12cmH2O) in normal sheep hearts (n = 5) persistent (PtAF, n 8)-remodelled subjected prolonged tachypacing. hypothesized that, presence of stretch, meandering 3D scroll waves (ASWs) anchor regions large...
<h3>Importance</h3> Critical illness, a marked inflammatory response, and viruses such as SARS-CoV-2 may prolong corrected QT interval (QTc). <h3>Objective</h3> To evaluate baseline QTc on 12-lead electrocardiograms (ECGs) ensuing changes among patients with without COVID-19. <h3>Design, Setting, Participants</h3> This cohort study included 3050 aged 18 years older who underwent testing had ECGs at Columbia University Irving Medical Center from March 1 through May 1, 2020. Patients were...
Background— Dominant frequencies (DFs) of activation are higher in the atria patients with persistent than paroxysmal atrial fibrillation (AF), and left (LA)-to-right (RA) DF gradients have been identified both. However, whether such maintained as long-term AF is established remains unexplored. We aimed at determining vivo time course values from to sheep testing hypothesis that an LA-to-RA difference associated LA drivers AF. Methods Results— was induced using RA tachypacing (n=8)....
Heart disease, a leading cause of death in the developed world, is overwhelmingly correlated with arrhythmias, where heart muscle cells, myocytes, beat abnormally. Cardiac arrhythmias are usually managed by electric shock intervention, antiarrhythmic drugs, surgery, and/or catheter ablation. Despite recent improvements techniques, ablation procedures still limited risk complications from unwanted cellular damage, caused nonspecific delivery ablative energy to all cell types. We describe an...
Background Epicardial adiposity and plasma levels of free fatty acids (FFAs) are elevated in atrial fibrillation, heart failure obesity, with potentially detrimental effects on myocardial function. As major components epicardial fat, FFAs may be abnormally regulated, a potential to detrimentally modulate electro-mechanical The cellular mechanisms underlying such unknown. Objective To determine the electrophysiological palmitic (PA), stearic (SA) oleic (OA) sheep myocytes. Methods We used...
Background: Obesity and diets high in saturated fat increase the risk of arrhythmias sudden cardiac death. However, molecular mechanisms are not well understood. We hypothesized that an dietary could lead to abnormalities calcium homeostasis heart rhythm by a NOX2 (NADPH oxidase 2)-dependent mechanism. Methods: investigated this hypothesis feeding mice high-fat diets. In vivo telemetry, optical mapping, isolated myocyte imaging were used quantify arrhythmias, repolarization, transients,...
Mechanistically driven therapies for atrial fibrillation (AF), the most common cardiac arrhythmia, are urgently needed, development of which requires improved understanding cellular signaling pathways that facilitate structural and electrophysiological remodeling occurs in atria. Similar to humans, increased persistent Na+ current leads an myopathy spontaneous long-lasting episodes AF mice. How causes both atria is unknown. We crossbred mice expressing human F1759A-NaV1.5 channels with...
Atrial fibrillation (AF) is the most common cardiac arrhythmia and accounts for substantial morbidity mortality. Recently, we created a mouse model with spontaneous sustained AF caused by mutation in NaV1.5 channel (F1759A) that enhances persistent Na+ current, thereby enabling investigation of molecular mechanisms cause identification potentially novel treatment strategies. The mice have regional heterogeneity action potential duration atria similar to observations patients AF. In these...
Leadless pacemakers (LPMs) have been shown to lower postoperative complications than traditional permanent but there no studies on the outcomes of LPMs in patients with transcatheter heart valve replacements (THVRs). This study determined compared transvenous single-chamber (SCPs) post-THVR.This is a retrospective single-center including 10 who received post-THVR between February 2017 and August 2018 comparison group 23 SCP July 2008 2018. LPM or was implanted at discretion...
Background: The mechanisms underlying spontaneous atrial fibrillation (AF) associated with ischemia/infarction are incompletely elucidated. Here, we investigate the AF in an ovine model of left myocardial infarction (LAMI). Methods and Results: LAMI was created by ligating branch anterior descending coronary artery. ECG loop recorders were implanted to monitor episodes. In 7 sheep, dantrolene—a ryanodine receptor blocker—was administered vivo during 8-day observation period (LAMI-D, 2.5...
The Ca2+-binding protein calmodulin has emerged as a pivotal player in tuning Na+ channel function, although its impact vivo remains to be resolved. Here, we identify the role of and NaV1.5 interactome regulating late current cardiomyocytes. We created transgenic mice with cardiac-specific expression human channels alanine substitutions for IQ motif (IQ/AA). mutations rendered incapable binding C-terminus. IQ/AA exhibited normal ventricular repolarization without arrhythmias an absence...
Abstract Obesity and diabetes increase the risk of arrhythmia sudden cardiac death. However, molecular mechanisms caused by metabolic abnormalities are not well understood. We hypothesized that mitochondrial dysfunction high fat diet (HFD) promotes ventricular arrhythmia. Based on our previous work showing saturated causes calcium handling in cardiomyocytes, we uptake contributes to HFD-induced arrhythmic events. For experiments, used mice with conditional cardiac-specific deletion uniporter...
Transient ST-T elevation (STE) is a rare complication that occurs during transseptal catheterization. This study aims to delineate the incidence and characteristics of transient STE catheterization for atrial fibrillation (AF) ablation. Consecutive patients who underwent fluoroscopy-guided circumferential pulmonary vein radiofrequency ablation in Beijing An Zhen Hospital from January 2006 2013 were enrolled this study. Out 2965 with total 3452 procedures, 13 (0.38%, mean age 57 ± 8, 6...
Prophylactic DeVega tricuspid annuloplasty (DVA) of the donor heart has been reported to improve regurgitation (TR), renal dysfunction, and mortality in cardiac transplant recipients. This is first study investigate electrical, as well as, hemodynamic effects DVA during orthotopic transplantation (OHT). Electrocardiographic, echocardiographic, data 76 patients with 104 without who underwent OHT between 2013 2017 at Columbia University Medical Center (New York, NY) were studied. Patients...
CKD remains incurable and is a one-way journey leading to kidney failure. Interventions slowing progression are of immense interest. Since the introduction angiotensin-converting enzyme inhibitors angiotensin receptor blockers few decades ago, emergence novel mineralocorticoid antagonists sodium-glucose cotransporter-2 revived enthusiasm for delaying CKD. Recently, another class drug that evoked curiosity bardoxolone, which was termed "blockbuster drug" foretoken not only arrest but also...