A5073224001- Geriatric Care and Nursing Homes
- Health disparities and outcomes
- Frailty in Older Adults
- Intergenerational Family Dynamics and Caregiving
- Palliative Care and End-of-Life Issues
- Genetic Associations and Epidemiology
- COVID-19 and healthcare impacts
- Nutrition and Health in Aging
- Liver Disease Diagnosis and Treatment
- Climate Change and Health Impacts
- Diabetes and associated disorders
- COVID-19 Clinical Research Studies
- Hip and Femur Fractures
- Health Systems, Economic Evaluations, Quality of Life
- Global Health Care Issues
- Alcohol Consumption and Health Effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Eating Disorders and Behaviors
- Childhood Cancer Survivors' Quality of Life
- Birth, Development, and Health
- Nutrition, Genetics, and Disease
- Obesity and Health Practices
- Aging and Gerontology Research
- Migration, Aging, and Tourism Studies
- Liver Disease and Transplantation
Newcastle University
2016-2025
Queen Mary University of London
2022-2025
University of London
2024
University College London
2023-2024
Universidad de Londres
2023-2024
Northumbria Healthcare NHS Foundation Trust
2024
University of Newcastle Australia
2024
Wellcome Sanger Institute
2023
William Harvey Research Institute
2023
Newcastle Hospitals - Campus for Ageing and Vitality
2018-2021
Timely recognition of the end life allows patients to discuss preferences and make advance plans, clinicians introduce appropriate care. We examined changes in frailty over 1 year, with aim identifying trajectories that could indicate where an individual is at increased risk all-cause mortality may require palliative care.Electronic health records from 13,149 adults (cases) age 75 who died during a 1-year period (1 January 2015 2016) were age, sex general practice matched individuals no...
loneliness has an adverse effect on health and well-being, is common at older ages. Evidence that it a risk factor for care home admission sparse. to investigate the association between admission. English Longitudinal Study of Ageing (ELSA). two-hundred fifty-four individuals across seven waves (2002–15) ELSA who moved into homes were age, sex matched four randomly selected remained in community. logistic regression models examined associations loneliness, socio-demographic factors,...
Background Late-life depression (LLD) is associated with a decline in physical activity. Typically this assessed by self-report questionnaires and, more recently, actigraphy. We sought to explore the utility of bespoke activity monitor characterize profiles LLD precisely. Method The was worn for 7 days 29 adults and 30 healthy controls. Subjects underwent neuropsychological assessment quality life (QoL) (36-item Short-Form Health Survey) activities daily living (ADL) scales (Instrumental...
recognising that a patient is nearing the end of life essential, to enable professional carers discuss prognosis and preferences for care.
Abstract Thyroid hormones play a critical role in regulation of multiple physiological functions and thyroid dysfunction is associated with substantial morbidity. Here, we use electronic health records to undertake genome-wide association study thyroid-stimulating hormone (TSH) levels, total sample size 247,107. We identify 158 novel genetic associations, more than doubling the number known associations TSH, implicate 112 putative causal genes, which 76 are not previously implicated. A...
Abstract South Asians develop type 2 diabetes (T2D) early in life and often with normal body mass index (BMI). However, reasons for this are poorly understood because genetic research is largely focused on European ancestry groups. We used recently derived multi-ancestry partitioned polygenic scores (pPSs) to elucidate underlying etiological pathways British Pakistani Bangladeshi individuals T2D ( n = 11,678) gestational mellitus (GDM) 1,965) the Genes & Health study 50,556). Beta cell...
Correct classification of type 1 (T1D) and 2 diabetes (T2D) is challenging due to overlapping clinical features the increasingly early onset T2D, particularly in South Asians. Polygenic risk scores (PRSs) for T1D T2D have been shown work relatively well Asians, despite being derived from largely European-ancestry samples. Here we used PRSs investigate rate potential misclassification amongst British Bangladeshis Pakistanis. Using linked health records Genes & Health cohort (n = 38,344)...
Despite growing interest surrounding the integration of genetic risk tools such as polygenic scores (PRSs) into routine care for early disease identification and management, major questions remain about whether how these are to be implemented at-scale. Many interventions have explored their use in encouraging adoption preventative health behaviours—yet existing evidence remains undetermined, limited by focus on White European populations. The present study used structural equation modelling...
Background General practice provides first-line National Health Service care for around 400,000 home residents. Good primary can enhance residents’ health and well-being optimise use of hospital services. Objectives This study aimed to explore the relationships between organisation general perspectives experiences residents, staff, outcomes costs. Design Survey practices (2018), qualitative (2019), analysis data (2019–21). Policy context England Vanguard funded innovation in services homes...
Late-life depression (LLD) is associated with poor social functioning. However, previous research uses bias-prone self-report scales to measure functioning and a more objective lacking. We tested novel wearable device speech that participants encounter as an indicator of interaction.Twenty nine LLD 29 age-matched controls wore wrist-worn continuously for seven days, which recorded their acoustic environment. Acoustic data were automatically analysed using deep learning models had been...
Obesity and rapid weight gain are established risk factors for noncommunicable diseases have emerged as independent severe disease following Coronavirus Disease 2019 (COVID-19) infection. Restrictions imposed to reduce COVID-19 transmission resulted in profound societal changes that impacted many health behaviours, including physical activity nutrition, associated with rate of gain. We investigated which clinical sociodemographic characteristics were the greatest acceleration during pandemic...
Understanding the genetic basis of routinely-acquired blood tests can provide insights into several aspects human physiology. We report a genome-wide association study 42 quantitative test traits defined using Electronic Healthcare Records (EHRs) ~50,000 British Bangladeshi and Pakistani adults. demonstrate causal variant within PIEZO1 locus which was associated with alterations in red cell glycated haemoglobin. Conditional analysis within-ancestry fine mapping confirmed that this signal is...