A5007978842- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiomics and Machine Learning in Medical Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Metastasis and carcinoma case studies
- RNA modifications and cancer
- Congenital Diaphragmatic Hernia Studies
- Myasthenia Gravis and Thymoma
- Trauma Management and Diagnosis
- Pneumothorax, Barotrauma, Emphysema
- Head and Neck Cancer Studies
- Gastric Cancer Management and Outcomes
- Multiple and Secondary Primary Cancers
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Soft tissue tumor case studies
- Advanced Radiotherapy Techniques
- Vascular Anomalies and Treatments
National Institutes for Quantum Science and Technology
2023-2024
Kanagawa Cardiovascular and Respiratory Center
2013-2022
Yokohama City University
1999-2019
Society of Thoracic Surgeons
2015
Kanagawa Prefectural Hospital Organization
1996-2007
Kansai Rosai Hospital
1998-2000
Kanagawa Cancer Center
1996-1998
Sanin Rosai Hospital
1998
Saiseikai Fukuoka General Hospital
1984
Kurume University
1980-1984
A new classification of adenocarcinoma ( ADC ) was proposed by the I nternational ssociation for S tudy L ung C ancer, merican T horacic ociety, and E uropean R espiratory ociety IASLC / ATS ERS in 2011. The present study evaluates its prognostic value stage disease J apanese cases. One‐hundred‐and‐seventy‐nine cases with pathological were classified according to system their association recurrence analyzed. Eighteen (10.1%) 24 (13.4%) situ AIS minimally invasive MIA ), respectively....
The present study investigated expression profiles of the potential CSC markers including CD 133, 44, ALDH 1, and β‐catenin, evaluated their prognostic value in lung adenocarcinomas. One‐hundred‐and‐seventy‐seven tumors (stage I ) were immunohistochemically examined for these markers, thresholds to subdivide levels determined using receiver operating characteristics curves. Tumors with high 133 (adjusted hazard ratio ( HR 4.55 (95% confidence interval CI 1.26–16.40, P = 0.021), 44 3.73, 95%...
Background Interstitial lung abnormalities (ILAs) are present at CT in about 10% of individuals undergoing cancer screening. The relationship between histologic findings ILAs and their influence on patient prognosis remains unknown. Purpose To evaluate the percentage preoperative CT, as measured by radiologists a computer-aided detection (CAD) software, predictor disease-free survival patients with cancer. Materials Methods This retrospective study evaluated 217 consecutive who underwent...
Video-assisted thoracic surgery (VATS) lobectomy for primary lung cancer is considered minimally invasive. However, different procedures may be used the VATS lobectomy, from complete videoscopic (CV) to a technique similar muscle-sparing thoracotomy. We divided patients into two groups based on surgical approach and analysed outcomes.Two hundred thirty-one were treated using one of procedures: video-supported method (VS, n = 63) CV (n 168). Patients by posterolateral thoracotomy (PL, 61)...
Background Surgical lung biopsy is generally considered the most appropriate method for diagnosing diffuse disease. However, there are few reports focusing on only one thoracoscopic technique. This study was designed to determine morbidity and mortality related video-assisted in a single center, thereby providing data severity of clarifying risk factors. Methods We analyzed 285 patients with undiagnosed disease who underwent at Kanagawa Cardiovascular Respiratory Center from February 2007...
We previously reported that patients with lung adenocarcinomas KRAS gene mutations and strong proliferating activity had poorer outcomes, even in the early stage of disease. The aim present study was to elucidate potential molecular basis these highly malignant tumors by focusing on S100 proteins (S100A2, S100A7, S100A11), which are downstream targets oncogenic promoters tumor progression. immunohistochemical expression examined 179 primary adenocarcinomas, relationships between their levels...
Aims To investigate the pathological features of idiopathic interstitial pneumonia ( IIP )‐associated pulmonary adenocarcinoma. Methods and results Surgically resected adenocarcinomas associated with (the group) without non‐ were subjected to analysis. Adenocarcinomas in group subdivided into two groups: one included tumours connected bronchiolar metaplasia honeycomb lesions H‐ group), other unrelated NH ‐ group). Histomorphological appearance immunohistochemical expression compared among...
Ciliated muconodular papillary tumors (CMPTs) are a recently categorized benign or low-grade malignant neoplasm that develops in the peripheral lung. Only about 40 cases have been reported to date, and clinicopathological characteristics yet be defined detail. Here, we present four of CMPTs with focus on their immunohistochemical profiles driver gene mutations. These were proliferation mixture ciliated, mucous, basal cells located Ciliated, mucous positive for TTF-1 when using clone SPT24,...
This study investigated the proteome modulated by oncogenic KRAS in immortalized airway epithelial cells. Chloride intracellular channel protein 4 (CLIC4), S100 proteins (S100A2 and S100A11), tropomyosin 2, cathepsin L1, integrinsα3, eukaryotic elongation factor 1, vimentin, others were discriminated. We here focused on CLIC4 to investigate its potential involvement carcinogenesis lung because previous studies suggested that some chloride channels regulators could function as tumor...
The traditional histologic classification of lung cancer is not satisfactory to describe the morphologic characteristics individual tumors, because it does fully cover cytologic features. This paper describes a novel typing system using morphometric profiling that covers variety features including architecture, cell type, cytoplasmic color and internal structure, nuclear outline, chromatin pattern, nucleoli count remarkableness, average deviation size circularity. In all, 201 cases tumors...
The purpose of this study was to define histological features determining the malignant potential EGFR-mutated lung adenocarcinoma (LADC). Surgically resected tumors (EGFR-mutated LADCs with (21) and without (79) lymph node metastasis EGFR wild-type (26) (108) metastasis) biopsy samples from inoperably advanced (78) (99)) were examined. In surgically tumors, had micropapillary element in a significantly greater proportion than others (Mann-Whitney tests P ≤0.026). higher LADC at stage (stage...
Gene silencing by promoter hypermethylation plays an important role in molecular pathogenesis. We previously reported that insulin‐like growth factor (IGF) binding protein‐4 (IGFBP‐4), which inhibits IGF‐dependent growth, is expressed via early response‐1 (EGR‐1) and often silenced cultivated lung cancer cells. The purpose of the present study was to clarify clinicopathological factors associated with IGFBP‐4 gene adenocarcinomas. Seventy‐six surgically resected adenocarcinomas (20 well‐, 35...
The aim of this study was to evaluate the efficacy Thopaz system, a new drainage system in management general thoracic surgery, based on review our clinical practice and comparison utility device compared with standard system.A 540 surgeries at hospital performed. These cases were divided into 275 treated from April 2014 March 2015 265 2013 2014. characteristics patients outcomes after surgery these 2 groups.The similar groups. Outcomes including types operation, period chest tube placement,...
Small non-protein coding RNA, microRNA (miR), which regulate messenger RNA levels, have recently been identified, and may play important roles in the pathogenesis of various diseases. The present study focused on miR-31 investigated its potential involvement lung carcinogenesis. expression was altered cancer cells through either amplification or loss host gene locus. strong large cell carcinomas attributed to amplification. Meanwhile, more frequently observed aggressive adenocarcinomas....