A5069224038- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Myasthenia Gravis and Thymoma
- Pleural and Pulmonary Diseases
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Head and Neck Cancer Studies
- Congenital Diaphragmatic Hernia Studies
- RNA modifications and cancer
- Congenital Heart Disease Studies
- Head and Neck Surgical Oncology
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Trauma Management and Diagnosis
- Meningioma and schwannoma management
- Ferroptosis and cancer prognosis
- Cardiac tumors and thrombi
- Cancer and Skin Lesions
- Tumors and Oncological Cases
Tottori University
2016-2025
Tottori University Hospital
2009-2023
The University of Texas Southwestern Medical Center
2017-2018
Southwestern Medical Center
2017-2018
University of Toyama
2017
National Cancer Center Hospital East
2012-2016
Tottori Prefectural Central Hospital
2009-2010
Background: Small cell lung cancer (SCLC) is a deadly, high grade neuroendocrine (NE) tumor without recognized morphologic heterogeneity. However, over 30 years ago we described SCLC subtype with "variant" morphology which did not express some NE markers and exhibited more aggressive growth. Methods: To quantitate properties of SCLCs, developed 50-gene expression-based score that could be applied to human tumors lines, genetically engineered mouse (GEM) models. We identified low subtypes in...
Video-assisted thoracoscopic surgery (VATS) for clinical stage I non-small cell lung cancer (NSCLC) has been widely used as a less invasive surgical procedure, but the resection method is still controversial. We retrospectively compared outcomes of lobectomy, segmentectomy and wedge resection.A total 411 patients with NSCLC who underwent VATS (218 males 193 females, aged 69.3 years; 345 adenocarcinomas, 57 squamous carcinomas, 9 others) were investigated. The procedure was lobectomy in 289,...
Although some retrospective studies have reported clinicopathological scoring systems for predicting postoperative complications and survival outcomes elderly lung cancer patients, optimized remain controversial.The Japanese Association Chest Surgery (JACS) conducted a nationwide multicentre prospective cohort enrolled total of 1019 octogenarians with medically operable cancer. Details the clinical factors, comorbidities comprehensive geriatric assessment were recorded 895 patients to...
J Oral Pathol Med (2010) 39 : 328–334 Background: Minichromosome maintenance (MCM) proteins act as the origin licensing machinery that regulates initiation of DNA replication. Geminin is a repressor and prevents reinitiation replication by blocking reloading MCM at origins. Recent studies have proposed MCM7 geminin may be sensitive proliferative prognostic markers various malignant tumors. This study aimed to analyze expression clarify pathobiological significance in human oral squamous cell...
Background/Aim: Podoplanin is a candidate cancer stem cell marker in squamous carcinoma (SCC). Several studies have reported the prognostic value of podoplanin expression tumor cells lung SCC but few focused on its cancer-associated fibroblasts (CAFs). The aim this study was to analyze significance expression, with special reference pattern both and CAFs. Patients Methods: Immunohistochemical analyses using anti-podoplanin antibody were performed 126 resected specimens SCC. When more than...
8064 Background: CRES 3 T is a multicenter, single-arm, confirmatory trial of S-1 plus cisplatin and concurrent radical-dose thoracic radiotherapy (TRT) followed by surgery in patients with superior sulcus tumor (SST). The 3-year overall survival (OS) progression-free (PFS) rates were 73% (95% confidence interval [CI]; 60–83%) 53% CI; 40–65%), respectively. primary endpoint, OS rate, was met. We report the exploratory analyses outcomes approximately 5 years after last patient enrolled....
The JIPANG study is a randomized phase III of pemetrexed/cisplatin (Pem/Cis) versus vinorelbine/cisplatin (Vnr/Cis) for completely resected stage II-IIIA non-squamous non-small cell lung cancer (Ns-NSCLC). This did not meet the primary endpoint (recurrence-free survival, RFS) but Pem/Cis had similar efficacy to Vnr/Cis with better tolerability. Tumor mutation burden (TMB) thought have predictive value immune checkpoint inhibitors. However, relevance TMB cytotoxic chemotherapy remains...
Lymph node dissection (LND) with robot-assisted thoracoscopic surgery (RATS) in lung cancer has not been fully evaluated. The aim of this study was to compare LND surgical results between video-assisted (VATS) and RATS.We retrospectively compared perioperative parameters, including the incidence LND-associated complications (chylothorax, recurrent and/or phrenic nerve paralysis bronchopleural fistula), lymph (LN) counts postoperative locoregional recurrence, among 390 patients primary who...
Non-small cell lung cancer (NSCLC) accounts for >85% of incidences cancer, which the predicted 5‑year survival rates are low and recurrence remain high. Although it has been reported that patients with SCLC cells possess cluster differentiation (CD) 117 marker exhibited poor prognosis response to chemotherapy, no studies concerning association CD117 expression NSCLC have reported. An in vitro study reportedly revealed CD117‑positive populations lines stem (CSC) phenotypes including...
Podoplanin expression in cancer-associated fibroblasts (CAFs) has been proposed as an unfavourable indicator squamous cell carcinoma of the lung, but little is known about its clinical significance early-stage lung adenocarcinoma. We evaluated prognostic impact podoplanin patients with pathological stage (p-stage) IA adenocarcinoma categorised by 8th edition tumour-node-metastasis classification for cancer.Immunohistochemical analyses using anti-podoplanin antibody were performed on resected...