A5046685193- Adipose Tissue and Metabolism
- Holomorphic and Operator Theory
- Cardiovascular and exercise physiology
- Muscle metabolism and nutrition
- Physical Activity and Health
- Algebraic and Geometric Analysis
- Exercise and Physiological Responses
- Muscle Physiology and Disorders
- Sports Performance and Training
- Genetics and Physical Performance
- Analytic and geometric function theory
- Advanced Harmonic Analysis Research
- High Altitude and Hypoxia
- Cancer, Hypoxia, and Metabolism
- Cancer survivorship and care
- Meromorphic and Entire Functions
- Lymphatic System and Diseases
- Muscle activation and electromyography studies
- Advanced Topics in Algebra
- Spectral Theory in Mathematical Physics
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Childhood Cancer Survivors' Quality of Life
- Obesity, Physical Activity, Diet
- Angiogenesis and VEGF in Cancer
Karolinska Institutet
2016-2025
Svenska Örtmedicinska Institute
2025
University of Tennessee at Knoxville
1998-2023
Institute of Medical Ethics
2022
Stockholm University
2022
Rohde & Schwarz (Germany)
2020
Karolinska University Hospital
1990-2017
Canadian Society for Exercise Physiology
2014
Stockholm School of Economics
2012
Swedish School of Sport and Health Sciences
2010
A low maximal oxygen consumption (VO2max) is a strong risk factor for premature mortality. Supervised endurance exercise training increases VO2max with very wide range of effectiveness in humans. Discovering the DNA variants that contribute to this heterogeneity typically requires substantial sample sizes. In present study, we first use RNA expression profiling produce molecular classifier predicts response. We then hypothesized genes would harbor contributed heterogeneous Two independent...
Regular endurance exercise training induces beneficial functional and health effects in human skeletal muscle. The putative contribution to the response of epigenome as a mediator between genes environment has not been clarified. Here we investigated DNA methylation associated transcriptomic changes well-controlled intervention study. Training were mirrored by significant alterations gene expression regions with homogeneous muscle energetics remodeling ontology. Moreover, signature separated...
The proper identification of differentially methylated CpGs is central in most epigenetic studies. Illumina HumanMethylation450 BeadChip widely used to quantify DNA methylation; nevertheless, the design an appropriate analysis pipeline faces severe challenges due convolution biological and technical variability presence a signal bias between Infinium I II probe types. Despite recent attempts investigate how analyze methylation data with such array design, it has not been possible perform...
mRNA expression of vascular endothelial growth factor (VEGF), fibroblast factor-2 (FGF-2), and hypoxia-inducible (HIF) subunits HIF-1α HIF-1β in human skeletal muscle was studied during endurance exercise at different degrees oxygen delivery. Muscle biopsies were taken before after 45 min one-legged knee-extension performed under conditions nonrestricted or restricted blood flow (∼15–20% lower) the same absolute workload. Exercise increased VEGF by 178% 340%, but not FGF-2. No significant...
Endurance training leads to many adaptational changes in several tissues. In skeletal muscle, fatty acid usage is enhanced and mitochondrial content increased. The exact molecular mechanisms regulating these functional structural remain be elucidated. Contractile activity-induced metabolic perturbation has repeatedly been shown important for the induction of biogenesis. Recent reports suggest that peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α)/mitochondrial...
The human hypoxia inducible factor 1 (HIF-1) system is activated under various pathological conditions, yet less known about its physiological regulation in healthy tissue. We have studied the effect of exercise on activation HIF-1 skeletal muscle. Employing a model where oxygen consumption increases and tension can be manipulated, nine male subjects performed 45 min one-legged knee-extension exercise. Biopsies were taken before, directly after, 30, 120, 360 after Exercise led to elevated...
A celebrated theorem in operator theory is A. Beurling's description of the invariant subspaces $H^2$ terms inner functions [Acta Math. {\bf81} (1949), 239--255; MR0027954 (10,381e)]. To do same thing for Bergman space $L^2_a$ has been deemed virtually impossible by many analysts, view fact that lattice so large, and may have weird properties as viewed from perspective. The size can be appreciated known essentially every on separable Hilbert realized compression shift $M\ominus N$, where $M$...
The molecular pathways that are activated and contribute to physiological remodeling of skeletal muscle in response endurance exercise have not been fully characterized. We previously reported ∼800 gene transcripts regulated following 6 wk supervised training young sedentary males, referred as the training-responsive transcriptome (TRT) (Timmons JA et al. J Appl Physiol 108: 1487-1496, 2010). Here we utilized this database together with data on biological variation adaptation aerobic both...
It has not been established which physiological processes contribute to endurance training-related changes (Delta) in aerobic performance. For example, the relationship between intramuscular metabolic responses at intensity used during training and improved human functional capacity examined a longitudinal study. In present study we hypothesized that improvements (Vo(2max)) control would combine equally explain enhanced Twenty-four sedentary males (24 +/- 2 yr; 1.81 0.08 m; 76.6 11.3 kg)...
Earl Berkson has shown that certain highly non-compact composition operators on the Hardy space H 2 are, in operator norm topology, isolated from all other operators.On hand, it is easy to see no compact so isolated.Here we explore intermediate territory, with following results: (i) Only extreme points of H°° unit hall can induce operators.In particular, those holomorphic self-maps disc whose images make at most finite order contact circle are not isolated.However, (ii) do tell whole story...
Abstract Purpose Exercise training is an effective and safe way to counteract cancer-related fatigue (CRF) improve health-related quality of life (HRQoL). High-intensity interval has proven beneficial for the health clinical populations. The aim this randomized controlled trial was compare effects resistance high-intensity (RT–HIIT), moderate-intensity aerobic (AT–HIIT) usual care (UC) in women with breast cancer undergoing chemotherapy. primary endpoint CRF secondary endpoints were HRQoL...
Lung cancer is the most frequent malignant neoplasm in countries, and main cancer-related cause of mortality worldwide both sexes combined. The geographic temporal patterns lung incidence, as well mortality, on a population level are chiefly determined by tobacco consumption, aetiological factor carcinogenesis. Other factors such genetic susceptibility, poor diet, occupational exposures air pollution may act independently or concert with smoking shaping descriptive epidemiology cancer....
Exercise has been suggested to ameliorate the detrimental effects of chemotherapy on skeletal muscle. The aim this study was compare different exercise regimens with usual care muscle morphology and mitochondrial markers in patients being treated for breast cancer. Specifically, we compared moderate-intensity aerobic training combined high-intensity interval (AT-HIIT) resistance (RT-HIIT) (UC). Resting biopsies were obtained pre- postintervention from 23 randomly selected women OptiTrain...
Advanced therapeutic strategies are often accompanied by significant adverse effects, which warrant equally progressive countermeasures. Physical exercise has proven an effective intervention to improve physical function and reduce fatigue in patients undergoing chemotherapy. Effects of high-intensity interval training (HIIT) this population not well established although HIIT other clinical populations. The aim the OptiTrain trial was examine effects concurrent resistance (RT-HIIT) or...
The acute metabolic response to sprint exercise was studied in 20 male and 19 female students. We hypothesized that the reduction of muscle glycogen content during would be smaller women than men a possible gender difference higher type II I fibers. exercise-induced increase blood lactate concentration 22% men. A considerable ATP (50%), phosphocreatine (83%), (35%) found fibers, it did not differ between genders. (17%) (78%) However, fibers 50% hypothesis indeed partly confirmed: attenuated...
Global gene expression profiling is used to generate novel insight into a variety of disease states. Such studies yield bewildering number data points, making it challenge validate which genes specifically contribute phenotype. Aerobic exercise training represents plausible model for identification molecular mechanisms that cause metabolic-related changes in human skeletal muscle. We carried out the first transcriptome-wide characterization muscle responses 6 wk supervised aerobic 8...
The aims of this study were 1) to characterize changes in matrix metalloproteinase (MMP), endostatin, and vascular endothelial growth factor (VEGF)-A expression skeletal muscle response a single bout exercise humans; 2) determine if any exchange endostatin VEGF-A between circulation the exercising leg is associated with change tissue or plasma concentration these factors. Ten healthy males performed 65 min cycle exercise, biopsies obtained from vastus lateralis at rest immediately 120 after...
Abstract Background Regular exercise reduces cardiovascular and metabolic disease partly through improved aerobic fitness. The determinants of exercise-induced gains in fitness humans are not known. We have demonstrated that over 500 genes activated response to endurance-exercise training, including modulation muscle extracellular matrix (ECM) genes. Real-time quantitative PCR, which is essential for the characterization lower abundance genes, was used examine 15 ECM potentially relevant...
The composition operator induced by a holomorphic self-map of the unit disc is compact on <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="upper L Superscript 1"> <mml:semantics> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msup> <mml:mi>L</mml:mi> <mml:mn>1</mml:mn> </mml:msup> </mml:mrow> <mml:annotation encoding="application/x-tex">{L^1}</mml:annotation> </mml:semantics> </mml:math> </inline-formula> circle if and only it Hardy space...
The delay in skeletal muscle mitochondrial ATP production at the onset of exercise is thought to be a function limited oxygen supply. delay, termed deficit, can quantified by assessing above baseline consumption during first few minutes recovery from exercise. During submaximal exercise, deficit reflected extent phosphocreatine (PCr) breakdown. In present study, nine male subjects performed 8 min submaximal, single leg knee extension after saline (Control) and dichloroacetate (DCA) infusion...
During endurance training, exercising skeletal muscle experiences severe and repetitive oxygen stress. The primary transcriptional response factor for acclimation to hypoxic stress is hypoxia-inducible factor-1alpha (HIF-1alpha), which upregulates glycolysis angiogenesis in low levels of tissue oxygenation. To examine the role HIF-1alpha we have created mice specifically lacking subjected them an training protocol. We found that only wild-type improve their oxidative capacity, as measured by...