A5070132920- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Toxic Organic Pollutants Impact
- Per- and polyfluoroalkyl substances research
- Metastasis and carcinoma case studies
- Acute Myeloid Leukemia Research
- Effects and risks of endocrine disrupting chemicals
- Cancer Cells and Metastasis
- Birth, Development, and Health
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Remote Sensing and Land Use
- Ferroptosis and cancer prognosis
- Safety and Risk Management
- Lung Cancer Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Protein Degradation and Inhibitors
- Therapeutic Uses of Natural Elements
- Retinal and Macular Surgery
- Pleural and Pulmonary Diseases
- Genetic factors in colorectal cancer
- Adrenal and Paraganglionic Tumors
- Zebrafish Biomedical Research Applications
Soochow University
2021-2025
Wuxi Ninth People's Hospital
2025
Nankai University
2023-2025
University of Toronto
2024
Qujiang People's Hospital
2024
Second Affiliated Hospital of Fujian Medical University
2024
Fujian Medical University
2024
Public Health Ontario
2024
Fujian Normal University
2022
Nanjing Medical University
2012-2021
Background Stroke was a major global public health challenge, and its prognosis remarkably associated with inflammation levels nutritional status. The advanced lung cancer index (ALI) comprehensive indicator that combined Currently, the relationship between ALI of stroke patients not yet known. purpose current study to estimate their relationship. Methods Cohort data from National Health Nutrition Examination Survey (NHANES) 1999–2018 were collected. association all-cause cardiovascular...
Perfluorooctane sulfonate (PFOS) is a widespread and persistent chemical in the environment. We investigated endocrine-disrupting effects of PFOS using combination vitro vivo assays. Reporter gene assays were used to detect receptor-mediated (anti-)estrogenic, (anti-)androgenic, (anti-)thyroid hormone activities. The effect on steroidogenesis was assessed both at levels supernatant expression hormone-induced genes H295R cell. A zebrafish-based short-term screening method developed endocrine...
Abstract Background Passive-active immunoprophylaxis against mother-to-child transmission (MTCT) of hepatitis B virus (HBV) recommends administering immunoglobulin (HBIG) and birth-dose vaccine in infants within 12 or 24 hours after birth. With this protocol, MTCT HBV still occurs 5–10% HBV-infected mothers with positive e antigen (HBeAg). The present study aimed to investigate whether earlier administration HBIG birth can further increase protection efficacy. Methods We conducted a...
Abstract Introduction: Tumor endothelial cells (ECs) support the tumor microenvironment and regulate status of cells. GPRC5B, enriched in ECs, is linked to poor prognosis colorectal cancer (CRC). Yet, influence GPRC5B on ECs its regulatory mechanism CRC stemness are still elusive. Therefore, this study aims clarify impact states, specific role GPRC5B-marked (GPRC5B+ ECs) tumor/stromal interactions mechanisms regulating stemness. Methods: We analyzed scRNA-seq data from 18 samples decode...
Abstract Introduction: Individual heterogeneity in colorectal cancer (CRC) remains a major challenge therapy optimization, despite diagnostic and treatment advances. CD8+ T cells, pivotal players anti-tumor immunity, display diverse functional subtypes shaped by interactions within the tumor microenvironment (TME). However, specific role of cells mediating through interacting with CRC as well their influence on immune response CRC, poorly understood. Here, we employ multi-transcriptomic...
Studies on the issue of whether elective cesarean section (ECS) may reduce mother-to-child transmission (MTCT) HBV in infants carrier mothers with high viremia (HBV DNA > 2 × 105 IU/ml) showed inconsistent results. In addition, breastfeeding cause MTCT is still a concern. We compared rates born to non-antiviral IU/ml different delivery and feeding modes. total, 460 their 462 (2 twin sets) were included. Hepatitis B surface antigen (HBsAg) antibodies against HBsAg (anti-HBs) quantitatively...
To investigate the incidence, clinical and microbiological features of febrile, risk factors during neutropenia periods in patients with hematological diseases.From October 20, 2014 to March 2015, consecutive who had diseases developed hospitalization were enrolled prospective, multicenter observational study.A total 784 episodes febrile occurred 1 139 neutropenic diseases. The cumulative incidence was 81.9% at 21 days after neutropenia. Multivariate analysis suggested that central venous...
The mechanism associated with the overproduction of aldosterone by aldosterone-producing adenomas (APA) is unknown.The objective study was to explore role D2 dopamine receptor (D2R) on synthesis and secretion clarify clinical importance this in APA.D2R expression APA examined 24 patients much less than that nontumorous adrenal cortex. D2R mRNA levels were inversely correlated CYP11B2 patient's plasma concentration. Angiotensin II (AII)-stimulated human adenocarcinoma cells (H295R) attenuated...
China is an endemic area for hepatitis E virus (HEV). The previous surveys of anti-HEV seroprevalence are cross-sectional. This study aimed to investigate the prevalence infection among pregnant women and their children in Jiangsu, China, observe postpartum evolution. Sera from 497 collected during pregnancy 6-year were screened by ELISA confirmed Western blotting. HEV RNA was detected reverse transcription-nested PCR. Of women, 3 (0.6 %) IgM positive 55 (11.1 IgG positive. At postpartum, 18...
Triclocarban (TCC), which is used as an antimicrobial agent in personal care products, has been widely detected aquatic ecosystems. However, the consequence of TCC exposure on embryo development still elusive. Here, by using zebrafish embryos, we aimed to understand developmental defects caused exposure. After 0.3, 30, and 300 μg/L from 4-hour postfertilization (hpf) 120 hpf, observed that significantly increased mortality malformation, delayed hatching, reduced body length. Exposure also...
Abstract Background During the early phase of COVID-19 vaccine rollout, low and middle-income countries (LMICs) were facing challenges in achieving equitable delivery. Few studies have contextualized global distributive injustice into national-specific contexts to understand its impact on delivery from an equity perspective. We aimed investigate factors influencing Philippines provide recommendations enhance LMICs prepare for future health emergencies. Methods The Health Equity...
To evaluate the clinical value of circulating tumor cells (CTC) count in peripheral venous blood patients with non-small cell lung carcinoma (NSCLC).A total 50 NSCLC who were diagnosed Wuxi No. 2 People's Hospital from January 2013 to December selected as group, 35 benign and 28 healthy subjects normal control group. Venous samples (3 mL) collected all for counting CTC, a result ≥8.7 was judged be positive. The relationships between positive rate CTC age, sex, pathological type, stage...
Objectives: China has implemented universal hepatitis B vaccination since 2002 and provided charge-free immunoglobulin (HBIG) to infants of HBV-infected mothers July 2011. We aimed compare mother-to-child transmission (MTCT) in children born before 2011.Methods: In total, 5,149 were tested for HBV markers. Group one contained 1,160 during August 2002–June 2011 group two 3,989 2011–June 2016.Results: 92 (1.8%, 95% confidence interval [95%CI] 1.4–2.2) infected with HBV. None (0%, 95%CI...
With the development of social economy, incidence gout is increasing, which closely related to people's increasingly rich diet. Eating a diet high in purine, fat, sugar and low-fibre for long time further aggravates by affecting uric acid metabolism. The renal metabolism mechanism has been thoroughly studied. To find new treatment method gout, increasing studies have recently conducted on intestinal excretion, absorption acid. most important research relationship between microbiota risk...
Resistance to cytarabine is an important cause of therapy failure in persons with acute myeloid leukemia (AML). Deoxycytidine kinase, encoded by DCK, catalyzes phosphorylation monophosphate, a necessary step for eventual incorporation triphosphate into DNA and clinical efficacy. Whether DCK mutations make AML cells resistant controversial. We studied messenger RNA (mRNA) concentrations from 10 subjects who received cytarabine-based relapsed 2 artificially induced cytarabine-resistant cell...
The epithelial-mesenchymal transition (EMT) is an important process during metastasis in various tumors, including colorectal cancer (CRC). Thus, the study of its characteristics and related genes great significance for CRC treatment. In this study, 26 EMT-related gene sets were used to score each sample from Cancer Genome Atlas program (TCGA) colon adenocarcinoma (COAD) database. Based on EMT enrichment scores sample, we performed unsupervised cluster analysis classified TCGA-COAD samples...
Hepatitis B e antigen (HBeAg) has been considered to cause immunotolerance hepatitis virus (HBV) in newborn infants after fetal HBeAg exposure. This study compared anti-HBs responses vaccination who were born HBeAg-positive and -negative mothers respectively, investigate whether exposure may induce HBV. Totally 265 received recommended neonatal immunoprophylaxis against had no HBV infection included. Anti-HBs levels between 124 with cord blood positive 141 negative at 7–12 months of age. The...
To evaluate the effect of combined diclofenac sodium and nuclear rotation on prevention posterior capsule opacification (PCO).Wuxi People's Hospital, Jiangsu, China.Comparative case series.In a preclinical trial, porcine eyes were randomized to have hydrodissection with (Group A), B), or control (balanced salt solution/lidocaine). Primary cells lens epithelium from obtained in each group. Proliferation coverage time for epithelial (LECs) noted. In clinical study, patients age-related...
Postvaccination serologic testing (PVST) is utilized to monitor the success or failure of vaccination against hepatitis B virus (HBV) infection in infants surface antigen (HBsAg) positive mothers. This secondary analysis 1255 HBsAg-positive mothers at 7-14 months age included two prospective studies aimed determine optimal interval for PVST after three vaccine doses. HBsAg and anti-HBs were quantitatively tested with microparticle enzyme immunoassay. The average was 3.8 ± 2.2 months....