A5100701632- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Infant Nutrition and Health
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Pediatric health and respiratory diseases
- Viral gastroenteritis research and epidemiology
- Neonatal Health and Biochemistry
- COVID-19 Impact on Reproduction
- Asthma and respiratory diseases
- Management of metastatic bone disease
- Blood donation and transfusion practices
- Vascular Malformations Diagnosis and Treatment
- Spinal Dysraphism and Malformations
- Heparin-Induced Thrombocytopenia and Thrombosis
- HIV/AIDS drug development and treatment
- COVID-19 Clinical Research Studies
- Respiratory and Cough-Related Research
- Polyomavirus and related diseases
- Inhalation and Respiratory Drug Delivery
- Pneumonia and Respiratory Infections
- Behavioral Health and Interventions
Mianyang Central Hospital
2025
University of Electronic Science and Technology of China
2025
Chinese University of Hong Kong, Shenzhen
2024
Anhui University of Science and Technology
2024
Guangdong Pharmaceutical University
2023
Nanjing Drum Tower Hospital
2015-2022
Huazhong University of Science and Technology
2020
Wuhan No.1 Hospital
2020
Amgen (United States)
2015
Hebei Medical University
2014
Spinal cord vascular malformations (SCVMs) in children are relatively rare and present unique challenges due to their distinct physiological characteristics. These often manifest with nonspecific clinical symptoms, increasing the likelihood of misdiagnosis. The treatment pediatric SCVMs requires a tailored approach, choice between microsurgical intervention endovascular embolization depending on specific type malformation individual patient factors. We report case 6-year-old male who...
Abstract Background Passive-active immunoprophylaxis against mother-to-child transmission (MTCT) of hepatitis B virus (HBV) recommends administering immunoglobulin (HBIG) and birth-dose vaccine in infants within 12 or 24 hours after birth. With this protocol, MTCT HBV still occurs 5–10% HBV-infected mothers with positive e antigen (HBeAg). The present study aimed to investigate whether earlier administration HBIG birth can further increase protection efficacy. Methods We conducted a...
Breast cancer is the females' most common cancer. Targeting immune microenvironment a new and promising treatment method for breast Nevertheless, only small section of patients can profit by immunotherapy, improving ability to accurately predict potential immunotherapy response still awaiting further exploration. In this study, we found that key factors glutamine metabolism, glutaminase 1 (GLS) mitochondrial aspartate transaminase (GOT2), showed opposite expression patterns in samples. Based...
Objectives: China has implemented universal hepatitis B vaccination since 2002 and provided charge-free immunoglobulin (HBIG) to infants of HBV-infected mothers July 2011. We aimed compare mother-to-child transmission (MTCT) in children born before 2011.Methods: In total, 5,149 were tested for HBV markers. Group one contained 1,160 during August 2002–June 2011 group two 3,989 2011–June 2016.Results: 92 (1.8%, 95% confidence interval [95%CI] 1.4–2.2) infected with HBV. None (0%, 95%CI...
Despite the presence of hepatitis B virus (HBV) in human breastmilk mothers infected with HBV, it has been shown that breastfeeding does not increase risk mother-to-child transmission (MTCT) HBV. We tested hypothesis may contain active components bind to HBV and inhibit infectivity The results show whey significantly inhibited binding surface antigen (HBsAg) its antibodies competitive inhibition immunoassays. far-western blotting showed HBsAg bound a protein 80 kD whey, which was identified...
As severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) mutates continually, the current vaccines are unable to provide sufficient protection. It is important develop a broad-spectrum vaccine with conserved antigens prevent variant infection. Here we fused SARS-CoV-2 N protein Helicobacter pylori nonheme ferritin construct N-Ferritin nanoparticle vaccine. Compared monomer protein, nanoparticles induced more lymph node dendritic cells in mice trigger adoptive immunity. Following this,...
Hepatitis B e antigen (HBeAg) has been considered to cause immunotolerance hepatitis virus (HBV) in newborn infants after fetal HBeAg exposure. This study compared anti-HBs responses vaccination who were born HBeAg-positive and -negative mothers respectively, investigate whether exposure may induce HBV. Totally 265 received recommended neonatal immunoprophylaxis against had no HBV infection included. Anti-HBs levels between 124 with cord blood positive 141 negative at 7–12 months of age. The...
Background: Failure of immunoprophylaxis in the prevention mother-to-infant transmission hepatitis B virus (HBV) is usually attributed to uterine infection. We aimed clarify whether presence HBV markers cord blood indicates exposure or infection with HBV.
Objective To investigate whether amniocentesis may increase the risk for mother-to-child transmission of hepatitis B virus (HBV). Methods Totally 40 children born to HBV-infected mothers who had performed in Nanjing Drum Tower Hospital, University Medical School from January 2010 December 2013, were followed up and screened HBV markers. Amniotic fluid samples collected stored at -80 ℃ tested Among carrier mothers, three (7.5%) e antigen (HBeAg)-positive. Relevant data such as...
The COVID-19 pandemic remarkably accelerated vaccine research progress. role of adjuvants in enhancing immune intensity and influencing types has been considered. Ginseng polysaccharide (GPS) demonstrated to have strong immunoregulatory properties. It is important explore the feasibility adding GPS adjuvant components improve response effect RBD vaccines. Here, we prepared a SARS-CoV-2 antigen using Escherichia coli expression system determined that subcutaneous administration at dose 40...
Background: Quantification of viral antigens and loads in human milk samples from mothers infected with hepatitis B virus is largely unknown. Research Aim: The aim the study was to quantitatively measure levels deoxyribonucleic acid virus. Methods: Fifty-five pairs serum positive surface antigen, including 11 e antigen positive, were tested by microparticle enzyme immunoassay real-time polymerase chain reaction assay. Results: median level or negative each lower than that sera, respectively...
Objective To investigate whether human breast milk may bind to hepatitis B surface antigen (HBsAg) and its characteristics. Methods Breast samples from five women with negative HBsAg antibody (anti-HBs) at one two months post delivery were fractioned into cream skimmedmilk by centrifugation. The each fraction as well cow goat samples, served controls, separately incubated highly purified yeast recombinant HBsAg, followed determination of their binding capability enzyme linked...
Objective Human milk of mothers with positive hepatitis B surface antigen (HBsAg) contains virus (HBV). However, breastfeeding does not increase the risk mother-to-infant transmission HBV. Previous investigations demonstrated that breast has a property binding HBsAg. This study aimed to identify component in human can bind HBsAg. Methods This was performed Nanjing Drum Tower Hospital, Affiliated Hospital University Medical School, from June 2015 February 2017. Human samples two...
Background: Despite the presence of hepatitis B virus (HBV) in human breastmilk mothers infected with HBV, breastfeeding does not increase risk mother-to-child transmission (MTCT) HBV. We hypothesized that may contain active component(s) binds to HBV and inhibits infectivity HBV.Methods: Competitive inhibition immunoassays far-Western blotting were used test binding whey surface antigen (HBsAg). The identity responsible for was determined by protein mass spectrometry. component on evaluated...
Abstract Objective Nucleos(t)ide analogues (NAs) naïve chronic hepatitis B(CHB) patients were given rescue combination therapy after drug resistance to lamivudine or adefovir. Evolution of HBV mutation patterns and its impact on antiviral effects studied. Methods Total 142 CHB treated with randomly divided into two groups when occurred. One group was added adefovir, the other switched entecavir Seventy-two adefovir lamivudine, entecavir. polymerase reverse transcriptase mutations associated...