A5005099889- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Cell Adhesion Molecules Research
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Radiomics and Machine Learning in Medical Imaging
- Melanoma and MAPK Pathways
- Cancer Genomics and Diagnostics
- Cardiovascular Disease and Adiposity
- Enzyme Structure and Function
- Inflammasome and immune disorders
- Head and Neck Cancer Studies
- Prion Diseases and Protein Misfolding
- Medical Imaging Techniques and Applications
- Cancer-related Molecular Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Genetic factors in colorectal cancer
- Cellular Mechanics and Interactions
- Autoimmune and Inflammatory Disorders Research
- Thyroid Cancer Diagnosis and Treatment
- Vaccine Coverage and Hesitancy
- Cell death mechanisms and regulation
Chang Gung University
2023-2024
Chang Gung Memorial Hospital
2017-2024
Linkou Chang Gung Memorial Hospital
2019-2024
Institute of Biomedical Sciences, Academia Sinica
2021
Tamkang University
2021
The Kinghorn Cancer Centre
2015
St Vincent's Hospital Sydney
2015
UCLA Jonsson Comprehensive Cancer Center
1999
University of California, Los Angeles
1999
The response rate to pioglitazone and the predictive factors for its effects on improving liver biochemistry in patients with steatotic disease (SLD) remain elusive, so we aimed investigate these issues.
The alterations of the cytoskeletal actin network have been implicated as a morphological effector in apoptosis. However, studies directly linking change to events apoptosis are lacking. This study quantitatively examined effect alteration on camptothecin (CPT)-induced apoptotic process HL-60 cells. Actin was induced by two distinctive types agent: polymerization-stimulating agent, Jasplakinolide (Jas), and polymerization-blocking cytochalasin B (CB). polymerization status measured...
Abstract The impacts of patatin‐like phospholipase domain‐containing protein 3 ( PNPLA3 ) I148M‐rs738409, methylenetetrahydrofolate reductase MTHFR Ala222Val‐rs1801133, and aldehyde dehydrogenase 2 ALDH2 Glu504Lys‐rs671 on the outcomes Taiwanese patients with steatotic liver disease (SLD) have remained elusive. An 8‐year prospective cohort study n = 546) without 580) SLD (controls) was undertaken in a tertiary care center. 546 comprised 306 (56.0%) men 240 (44.0%) women mean ages 53.3 56.4...
ABSTRACT We have constructed strains that allow a direct selection for mutators of Escherichia coli on single plate medium. The is based using two different markers whose reversion enhanced by given mutator. Plates containing limiting amounts each respective nutrient the growth ghost colonies or microcolonies give rise to full-size only if event occurs. Because successive mutational events are required, mutator cells favored generate colonies. Reversion third marker allows visualization...
Background: Hepatocellular carcinoma (HCC) remains a significant concern for patients with chronic hepatitis C (HCV), even after achieving sustained virological response (SVR) direct-acting antivirals (DAAs) or interferon (IFN)-based therapies. This study compared the risk of HCC in HCV who achieved SVR through DAA versus IFN regimens. Methods: A retrospective analysis was conducted on 4806 patients, without coinfection nor prior history, treated at Chang Gung Memorial Hospital, Taiwan (DAA:...
AIMTo explore factors associated with persistent hepatitis B virus (HBV) infection in a cohort of hepatocellular carcinoma (HCC)-affected families and then investigate that correlate individual viral load among surface antigen (HBsAg)-positive relatives. METHODSWe evaluated non-genetic HBV replication relatives patients HCC.Relatives 355 HCC cases were interviewed using structured 876 February 7, 2017|Volume 23|Issue 5| WJG|www.wjgnet.com
Fibrosis-4 (FIB4), transient elastography (TE), and acoustic radiation force impulse (ARFI) are popular modalities to assess liver fibrosis. Their cutoff values for degrees of fibrosis vary between studies. The influence hepatic steatosis on measurements different etiologies was evaluated. Data from a consecutive series patients who received measurement were included the training group. An additional with histology served as validation A standardized protocol performed both TE ARFI, mostly...
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination early diagnosis of hepatoma, complications their preventions treatments, etc.
The alterations of the cytoskeletal actin network have been implicated as a morphological effector in apoptosis. However, studies directly linking change to events apoptosis are lacking. This study quantitatively examined effect alteration on camptothecin (CPT)-induced apoptotic process HL-60 cells. Actin was induced by two distinctive types agent: polymerization-stimulating agent, Jasplakinolide (Jas), and polymerization-blocking cytochalasin B (CB). polymerization status measured...
Acoustic radiation force impulse (ARFI) imaging is a popular modality to measure liver fibrosis. ARFI selects optimal locations for measurement under guiding. However, there are concerns on study and observers bias. To decrease the variations, at two was measured with standardized protocol. This attempted establish its cutoff values according Metavir fibrosis score in different etiologies.A consecutive series of patients who received histology were prospectively enrolled. All cases had...
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination early diagnosis of hepatoma, complications their preventions treatments, etc.
Genome-wide association studies from Asia indicate that HLA-DP and HLA-DQ loci are important in persistent hepatitis B virus (HBV) infections. One of the key elements for HBV-related carcinogenesis is viral replication inflammation.To examine genetic nongenetic factors with HBV infection load families hepatocellular carcinoma (HCC).The HCC included 301 surface antigen (HBsAg) carriers 424 noncarriers born before nationwide vaccination program was initiated 1984. Five single nucleotide...
Acoustic radiation force impulse (ARFI) is used to measure liver fibrosis and predict outcomes. The performance of elastography in assessment poorer hepatitis B virus (HBV) than other etiologies chronic disease.To evaluate the ARFI long-term outcome prediction among different disease.Consecutive patients who received an study between 2011 2018 were enrolled. After excluding dual infection, alcoholism, autoimmune hepatitis, others with incomplete data, this retrospective cohort divided into...
Introduction: A deep learning algorithm to quantify steatosis from ultrasound images may change a subjective diagnosis objective quantification. We evaluate this in patients with weight changes. Materials and Methods: Patients (N = 101) who experienced changes ≥ 5% were selected for the study, using serial studies retrospectively collected 2013 2021. After applying our exclusion criteria, 74 239 included. classified into four scanning views applied algorithm. Mean values 3–5 each group used...
Background: The definition of large-volume pathologic N 1 metastases has been changed in the 2017 version National Comprehensive Cancer Network (NCCN) guidelines, leading to a controversy over optimal surgical approach selection for patients with papillary thyroid carcinoma (PTC). Aim: aim this study was investigate therapeutic efficacy total thyroidectomy (TT) and lobectomy (TL) these patients. Methods: In 906 consecutive PTC ≤ 5 mm were retrieved from Surveillance, Epidemiology, End...