A5101538083- Musculoskeletal pain and rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Acupuncture Treatment Research Studies
- Microbial Natural Products and Biosynthesis
- Pain Management and Placebo Effect
- scientometrics and bibliometrics research
- Complementary and Alternative Medicine Studies
- Biochemical and Structural Characterization
- Multiple Sclerosis Research Studies
- Acute Myocardial Infarction Research
- Health and Medical Research Impacts
- Thermoregulation and physiological responses
- Bacterial Genetics and Biotechnology
- Peptidase Inhibition and Analysis
- Drug-Induced Ocular Toxicity
- Academic Publishing and Open Access
- S100 Proteins and Annexins
- Plant biochemistry and biosynthesis
- Infrared Thermography in Medicine
- Health Systems, Economic Evaluations, Quality of Life
- Peripheral Neuropathies and Disorders
- Spine and Intervertebral Disc Pathology
Nankai University
2025
Guangzhou University of Chinese Medicine
2021-2022
Guangdong Provincial Hospital of Traditional Chinese Medicine
2021
Sun Yat-sen University
2010-2015
The First Affiliated Hospital, Sun Yat-sen University
2015
Technische Universität Dresden
2012-2014
Hunan Normal University
2012
Abstract The reconstruction of a natural product biosynthetic pathway from bacteria in vector and subsequent heterologous expression technically amenable microbial system represents an efficient alternative to empirical traditional methods for functional discovery, yield improvement, genetic engineering produce “unnatural” derivatives. However, the cloning procedure based on genomic library construction screening are complicated due large size (>10 kb) most pathways. Here, we describe...
Abstract Natural product peptide‐based proteasome inhibitors show great potential as anticancer drugs. Here we have cloned the biosynthetic gene cluster of a potent inhibitor—glidobactin from Burkholderia DSM7029—and successfully detected glidobactins/luminmycins in E. coli Nissle. We also improved yield glidobactin A tenfold by promoter change heterologous host. In addition, two new intermediates were identified comparative MS/MS fragmentation analysis. Identification acyclic luminmycin E...
Objectives: As novel therapeutics have been extensively studied in alopecia areata (AA) randomized controlled trials (RCTs), a placebo is often used as control. The response varied widely across different trials, and the influencing factors remained unknown. Therefore, comprehensive understanding of crucial for guiding AA drug development. This study aimed to establish model identify critical response. Methods: A systematic bibliographic search was conducted PubMed, EMBASE Cochrane library...
Abstract Introduction: Individual heterogeneity in colorectal cancer (CRC) remains a major challenge therapy optimization, despite diagnostic and treatment advances. CD8+ T cells, pivotal players anti-tumor immunity, display diverse functional subtypes shaped by interactions within the tumor microenvironment (TME). However, specific role of cells mediating through interacting with CRC as well their influence on immune response CRC, poorly understood. Here, we employ multi-transcriptomic...
Background Although there is a growing research base on low back pain, the bibliometric literature related to it deficient. The aim of this study was conduct and visualization analysis pain provide broad view current trends in LBP potential guide discipline. Methods authors searched Web Science extract publications regarding found total 12,249 during period 22 years, among which 12,242 were eligible. We classified analyzed such as citations, average citations per item, H-index, types,...
Abstract Background Despite the increasing research on low back pain, bibliometric literature in field of pain is limited. The aim this study was to perform a and visualization analysis pain. Methods authors searched Web Science database extract publications regarding last 22 years. A total 12,201 were eligible. We classified analyzed such as citations, average citations per item, H-index, types, countries/regions, institutions journals by using standard indicators. Bibliometric methods...