A5101525628- Cancer Cells and Metastasis
- Genomics, phytochemicals, and oxidative stress
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Sirtuins and Resveratrol in Medicine
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- TGF-β signaling in diseases
- Hip and Femur Fractures
- Medical Research and Treatments
- Temporomandibular Joint Disorders
- Global Maternal and Child Health
- Collagen: Extraction and Characterization
- BRCA gene mutations in cancer
- Tunneling and Rock Mechanics
- Bioactive Compounds and Antitumor Agents
- Facial Rejuvenation and Surgery Techniques
- Reproductive Health and Contraception
- Infectious Diseases and Mycology
- Kruppel-like factors research
- Cerebral Venous Sinus Thrombosis
Hunan Normal University
2025
Zhejiang Provincial People's Hospital
2012-2023
Southwest Petroleum University
2022
Jiangsu Normal University
2022
Hangzhou Medical College
2021
Australian Regenerative Medicine Institute
2020
Monash University
2020
Luoyang Orthopedic-Traumatological Hospital of Henan Province
2017-2020
Shanghai Institute of Planned Parenthood Research
2019
Fudan University
2019
// Jiguang Ma 1,* , Wanxing Duan Suxia Han 1 Jianjun Lei 2 Qinhong Xu Xin Chen Zhengdong Jiang Ligang Nan Jiahui Li Ke Liang Zheng Wang Xuqi 3 Erxi Wu 4 Xiongwei Huo Department of Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China Hepatobiliary Surgery, General Pharmaceutical Sciences, North Dakota State Fargo, ND, USA * These authors have contributed equally to this work Correspondence to: Han, email: Huo, Keywords : lipogenesis, cancer metabolism, ginkgolic acid...
Background/Aims: Sulforaphane (SFN) is known for its potent bioactive properties, such as anti-inflammatory and anti-tumor effects. However, effect on pancreatic cancer still poorly understood. In the present study, we explored therapeutic potential of SFN disclosed underlying mechanism. Methods: Panc-1 MiaPaca-2 cell lines were used in vitro. The biological function was measured using EdU staining, colony formation, apoptosis, migration invasion assays. Reactive oxygen species (ROS)...
Abstract Hyperactive EGF receptor (EGFR) and mutant p53 are common genetic abnormalities driving the progression of non–small cell lung cancer (NSCLC), leading cause deaths in world. The Drosophila gene Dachshund (Dac) was originally cloned as an inhibitor hyperactive EGFR alleles. Given importance signaling etiology, we examined role DACH1 expression development. protein mRNA reduced human NSCLC. Reexpression NSCLC colony formation tumor growth vivo via p53. Endogenous colocalized with a...
// Na-Na Tao 1, * , Hong-Zhong Zhou Hua Tang 2, Xue-Fei Cai 1 Wen-Lu Zhang Ji-Hua Ren Li 3 Xiang Chen Ke Wan-Yu Bo Liu Qiu-Xia Yang Sheng-Tao Cheng Li-Xia Huang Ai-Long 2 Juan Key Laboratory of Molecular Biology for Infectious Diseases (Ministry Education), Institute Viral Hepatitis, Department Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China Collaborative Innovation Center Diagnosis and Treatment Zhejiang Zhejiang, Epidemiology, School Public Health...
Enhanced aldehyde dehydrogenase (ALDH) activity has been shown to serve as a hallmark for cancer stem cells (CSCs). Recent evidence suggests that its role cell-related marker come down the specific isoform. However, little is known about ALDH isoform contributing aldefluor in gastric cancer. In this study, we isolated ALDHbright from 2 human cell lines MKN-45 and SGC‑7901 by using an Aldefluor assay found elevated self-renewal, differentiation tumorigenicity, demonstration of stemness...
<title>Abstract</title> Antimicrobial peptides (AMPs) show great potential in combating multi-drug resistant (MDR) bacteria, but their clinical application is limited by issues such as proteolytically labile, nonspecific membrane lysis toxicity and high manufacturing costs. Herein, we proposed a multi-modification strategy integrating sequence truncation, substitution of unnatural amino acids like 2,3-Diaminopropionic acid 3,3-diphenylpropanoic acid, miniPEG modification. This uses...
Pancreatic cancer is a lethal disease in part because of its potential for aggressive invasion and metastasis. Lipoxin A4 (LXA4) one the metabolites that derived from arachidonic acid catalyzed by 15-lipoxygenase (15-LOX), it has recently been reported to exhibit anti-cancer effects. However, role LXA4 pancreatic remains be elucidated. cell lines were treated with vehicle or LXA4, invasive capacity was then assessed Transwell assays. The expression epithelial mesenchymal markers determined...
Nrf2 (NF‐E2‐related factor 2) pathway and autophagy both can respond to oxidative stress promote cancer cells survive in the tumor microenvironment. We, therefore, explored relevance between pancreatic upon stimulation of reactive oxygen species (ROS). Pancreatic were cultured under controlled ROS stressing condition or basal condition. Different inhibitors used prevent at particular stages. siRNA was inhibit activation. Ad‐mRFP‐GFP‐LC3 infection monitor autophagic flux. The result shows...
Rosiglitazone metformin adduct (RZM) is a novel compound, synthesized from rosiglitazone (Ros) and (Met) combined at molar mass ratio of 1:1. Met Ros are widely used together for treating type 2 diabetes to improve drug effectiveness reduce adverse reactions. Recent studies reported that both may possess antineoplastic properties in several cancers, including hepatocellular carcinoma (HCC). However, the effects RZM HCC its underlying mechanisms remain unknown. was an equal identified by...
Resistance to polymyxin antibiotics is increasing. Without new antibiotic classes, combination therapy often required. We systematically investigated bacterial killing with polymyxin-based combinations against multidrug-resistant (including polymyxin-resistant), carbapenemase-producing Klebsiella pneumoniae . Monotherapies and double- triple-combination therapies were compared identify the most efficacious treatment using static time-kill studies (24 h, six isolates), an in vitro...
The intestine function recovery decoction (IFRD) is a traditional Chinese medicine that has been used for the treatment of adhesive intestinal obstruction. In this study, preventative effects and probable mechanism IFRD were investigated in rat model. We randomly assigned rats to five groups: normal, model, control, low dose IFRD, high IFRD. animal caecum wall parietal peritoneum abraded induce intra-abdominal adhesion formation. Seven days after surgery, scores assessed using visual scoring...
Abstract Mixed mucinous cystadenoma with serous of the pancreas is rare. There have been only two previous case reports in English-language literature. We present a 46-year-old woman who was diagnosed mixed pancreas. Computed tomography and magnetic resonance imaging showed cystic neoplasm dorsal/proximal body clear-margin multilocular cavity enhanced internal septum. The patient underwent laparoscopic central pancreatectomy. diagnosis confirmed by pathological examination. followed up for 3...