A5038040398- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Metabolism, Diabetes, and Cancer
- MicroRNA in disease regulation
- FOXO transcription factor regulation
- Hedgehog Signaling Pathway Studies
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Pancreatitis Pathology and Treatment
- TGF-β signaling in diseases
- Proteoglycans and glycosaminoglycans research
- Genomics, phytochemicals, and oxidative stress
- Nerve injury and regeneration
- Cancer Genomics and Diagnostics
- Fibroblast Growth Factor Research
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Natural product bioactivities and synthesis
- Protein Degradation and Inhibitors
- RNA Interference and Gene Delivery
First People's Hospital of Yunnan Province
2021-2025
Kunming University of Science and Technology
2021-2025
First Affiliated Hospital of Xi'an Jiaotong University
2017-2019
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-associated mortality worldwide with an overall five-year survival rate less than 7%. Accumulating evidence has revealed cancer preventive and therapeutic effects metformin, one most widely prescribed medications for type 2 diabetes mellitus. However, its role in pancreatic not fully elucidated. Herein, we aimed to further study metformin genetically engineered mouse models cancer. LSL-KrasG12D/+; Pdx1-Cre (KC)...
NAF-1 (nutrient-deprivation autophagy factor-1), which is an outer mitochondrial membrane protein, known to play important roles in calcium metabolism, antiapoptosis, and antiautophagy. Resveratrol, a natural polyphenolic compound, considered as potent anticancer agent. Nevertheless, the molecular mechanisms underlying effects of resveratrol their mediation drug resistance pancreatic cancer remain unclear. Here, we demonstrate that suppresses expression cells by inducing cellular reactive...
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with mortality rate that closely parallels its incidence rate, and better understanding of the molecular cellular mechanisms associated invasion distant metastasis required. Heat shock factor 1 (HSF1) very highly conserved in eukaryotes regulates protective heat response. Here, we show HSF1 abnormally activated pancreatic cancer. The knockdown impaired migration epithelial-mesenchymal transition (EMT) cancer cells vitro; however,...
Gemcitabine is a standard treatment for advanced pancreatic cancer patients but can cause chemoresistance during treatment. The chemoresistant cells have features of stem (CSCs). Resveratrol has been reported to overcome the resistance induced by gemcitabine. However, mechanism which resveratrol enhances chemosensitivity remains elusive. Here, we explored enhanced and role sterol regulatory element binding protein 1 (SREBP1) in gemcitabine-induced stemness.The cell lines MiaPaCa-2 Panc-1...
Activation of pancreatic stellate cells (PSCs) initiates fibrosis in chronic pancreatitis and furnishes a niche that enhances the malignancy cancer (PCCs) ductal adenocarcinoma (PDAC). Resveratrol (RSV), natural polyphenol, exhibits potent antioxidant anticancer effects. However, whether how RSV influences biological properties activated PSCs effects these changes on tumor remain unknown. In present study, we found impeded hydrogen peroxide-driven reactive oxygen species- (ROS-) induced...
Pancreatic stellate cells ( PSC s), a key component of the tumor microenvironment, contribute to invasion, metastasis, and chemoresistance. Osteopontin OPN ), phosphorylated glycoprotein, is overexpressed in pancreatic cancer. However, expression s its potential roles tumor–stroma interactions remain unclear. The present study first showed that highly expressed secreted activated driven by hypoxia, this process ROS ‐dependent manner; addition, was shown be involved ‐induced...
Abstract The existences of cancer stem cells in patients with pancreatic are considered as pivotal factors contributing to chemoresistance and disease relapse. Glypican‐4 (GPC4) is one the members glypicans family, which underlies human congenital malformations multiple diseases. However, its potential biological function still remains elusive. In this study, we first demonstrate that GPC4 was involved 5‐fluorouracil (5‐FU) resistance stemness through comprehensive bioinformatical analysis....
Cancer stem cells (CSCs), which are found in various types of human cancer, including pancreatic possess elevated metastatic potential, lead to tumor recurrence and cause chemoradiotherapy resistance. Alterations cellular bioenergetics through the regulation 5' adenosine monophosphate‑activated protein kinase (AMPK) signaling may be a prerequisite stemness. Betulinic acid (BA) is well‑known bioactive compound with antiretroviral anti‑inflammatory has been reported exert anticancer effects on...
Sonic hedgehog (SHH) signaling is an important promotor of desmoplasia, a critical feature in pancreatic cancer stromal reactions involving the activation stellate cells (PSCs). Gremlin 1 widely overexpressed cancer-associated cells, including activated PSCs. In embryonic development, SHH potent regulator through interaction network. This subtle mechanism microenvironment remains to be fully elucidated. The present study investigated association between and SHH, effect cancer. expression...
Breast cancer (BC) is the most frequently diagnosed in women. Increasing evidence suggests that circular RNA (circRNA) exerts critical functions BC progression. However, roles of circRNA septin 9 (circSEPT9) development and underneath mechanism remain largely unclear so far. In this work, levels circSEPT9, microRNA-149-5p (miR-149-5p) solute carrier family 1 member 5 (SLC1A5) were detected by quantitative real-time polymerase chain reaction. Western blot was performed to check protein...
Papillary thyroid carcinoma (PTC) is the most common type of cancer. LncRNA HOTAIR (HOx Transcript AntIsense RNA) and Galectin-3 are involved in PTC. This study explored clinical effect lncRNA HOTAIR/Galectin-3 on PTC patients.Subjects were assigned into (160 cases) benign tumor groups (150 cases). Fasting peripheral venous blood was collected. expressions serum detected. Subjects HOTAIR/Glactin-3 high/low expression their correlation with age, gender, BMI, size, pathological stage, TSH,...
Gold nanoparticles (NPs) (GNPs) had been a hot spot in recent years and widely used drug carriers. GNPs could be directly synthesized showed very good physical chemical properties. To analyze the mechanism of ulinastatin (UTI) based on proliferation migration breast cancer cells (BCC), UTI@GNPs was prepared applied treatment sub-cultured MDA-MB-231 human BCC. According to different dosage regimens, BCCs divided into S0 group (normal saline), S1 (200 U/mL UTI@GNPs), S2 (700 UTI@GNPs) S3...