A5054321315- Synthesis and Biological Evaluation
- Coccidia and coccidiosis research
- Milk Quality and Mastitis in Dairy Cows
- Gut microbiota and health
- Advanced Drug Delivery Systems
- Antibiotics Pharmacokinetics and Efficacy
- Curcumin's Biomedical Applications
- Effects of Environmental Stressors on Livestock
- Environmental Toxicology and Ecotoxicology
- Vibrio bacteria research studies
- Animal Disease Management and Epidemiology
- Veterinary Pharmacology and Anesthesia
- Folate and B Vitamins Research
- Bacteriophages and microbial interactions
- Biochemical and Structural Characterization
- Microbial Metabolism and Applications
- Advancements in Transdermal Drug Delivery
- Sulfur Compounds in Biology
- Child Nutrition and Water Access
- Drug-Induced Ocular Toxicity
- Digestive system and related health
- Heavy Metal Exposure and Toxicity
- Poisoning and overdose treatments
- Parasitic Infections and Diagnostics
- Clostridium difficile and Clostridium perfringens research
Nanjing Agricultural University
2018-2025
Maduramicin, an extensively used anticoccidial drug, has been introduced into environment due to poorly absorbed in the intestine of broiler chicken. To understand potential ecological toxicity maduramicin on aquatic organisms, acute and subacute toxicity, hemolymph biochemistry, histopathology expressions drug metabolism stress response genes crayfish (Procambius clarkii) were investigated this study. For first time, 96 h median lethal concentration (LC50) was 67.03 mg L−1 with a 95%...
Klebsiella pneumoniae is an opportunistic pathogen that causes serious infections in humans and animals. However, the availability of epidemiological information on clinical mastitis due to K. limited. To acquire new regarding mastitis, data were mined about strains dairy cattle farms (farms A H) 7 Chinese provinces 2021. Hypermucoviscous obtained by string test. MICs antimicrobial agents determined via broth microdilution method. Ten resistance genes virulence identified PCR. The prevalence...
Recent developments in the field of machine learning andwearable sensor technology have led to a renewed interest efficient monitoring cattle health conditions. Wearable inertial sensors are particularly suited for noninvasive solution assess by continuously providing their daily behavior information. However, current classification methods limitations terms lack interpretability analysis resulting models combined behaviors. In this study, data-driven assessment approach was proposed...
Copper (Cu) is an essential trace element for animals, and also important nutritional component the normal physiology metabolism of animal reproductive systems. An excess or lack Cu will directly indirectly affect activities. However, effect Cu, in particular excessive on performance sows has not been studied. Here, we report that had negative effects oocyte maturation organelle functions. We showed exposure perturbed porcine meiotic impaired spindle/chromosome structure, resulting a...
Avian influenza (AI), caused by H9N2 subtype avian virus (AIV), poses a serious threat to poultry farming and public health due its transmissibility pathogenicity. The PB2 protein is major component of the viral RNA polymerase complex. It great importance identify antigenic determinants explore function protein. In this study, sequence AIV, from 1090 1689 bp, was cloned expressed. recombinant with cutting gel used immunize BALB/c mice. After cell fusion, hybridoma lines secreting monoclonal...
Maduramicin is a toxic ionophore antibiotic that isolated from Streptomyces, frequently occurring in an aquatic environment. To understand the potential role of maduramicin crayfish consumption related Haff disease, mouse model was established this study. Two exposure routes abdominal muscle and hepatopancreas tissue homogenates were given intragastrically to mice different doses for seven days. Action changes, clinical symptoms, feed consumption, body weight, blood biochemistry,...
Background: Staphylococcus aureus is a widely distributed and highly pathogenic zoonotic bacterium. Sortase A represents crucial target for the research development of novel antibacterial drugs. Objective: This study aims to establish quantitative structure-activity relationship models based on chemical structures class benzofuranene cyanide derivatives. The will be used screen new agents predict properties these molecules. Method: compounds were randomly divided into training set test set....
Maduramicin (MAD) is widely introduced into aquatic environments and results in the contamination of fish products. Worryingly, consumption MAD-contaminated crayfish (Procambarus clarkii) may induce symptoms Haff disease. In this study, to monitor potential understand residue elimination characteristics MAD edible tissues crayfish, a sensitive efficient ultra-performance liquid chromatography–tandem mass spectrometry method was developed, validated, applied. After extraction with...
Streptococcus uberis is a common cause of mastitis. The pathogenicity among different strains S. and the resultant host immune responses remain to be elucidated. Herein, we document three uberis, preliminary explore whether how intestinal immunity plays role in anti-infection processes. Mice have been proved effective experimental animals for bovine mastitis, so utilizing mouse intramammary infection model, assay gut flora changes by histopathologic examination, RT-PCR, Western blot, 16s...
Streptococcus uberis (S. uberis) is an important causative agent of mastitis, leading to significant economic losses dairy industry. This research used a mouse mastitis model investigate the protective effects taurine on mammary inflammatory response and blood-milk barrier integrity in S.uberis challenge. The results showed that attenuated S.uberis-induced histopathological changes, especially neutrophil infiltration. expression pro-inflammatory mediators were decreased significantly by...