A5027284627- Renal cell carcinoma treatment
- Renal and related cancers
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Telomeres, Telomerase, and Senescence
- Sirtuins and Resveratrol in Medicine
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- PARP inhibition in cancer therapy
- Cancer Genomics and Diagnostics
- Redox biology and oxidative stress
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Genomics and Chromatin Dynamics
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Galectins and Cancer Biology
- Acute Myeloid Leukemia Research
- Tuberous Sclerosis Complex Research
- Kidney Stones and Urolithiasis Treatments
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Zhongshan Hospital
2015-2024
Fudan University
2015-2024
Sun Yat-sen University
2015-2024
University School
2023
East China University of Science and Technology
2022
Shanghai Jiao Tong University
2022
Chinese Academy of Sciences
2022
Binzhou University
2022
Binzhou Medical University
2022
Abstract Senescent cells remain metabolically active, but their metabolic landscape and resulting implications underexplored. Here, we report upregulation of pyruvate dehydrogenase kinase 4 (PDK4) upon senescence, particularly in some stromal cell lines. display a PDK4-dependent increase aerobic glycolysis enhanced lactate production maintain mitochondrial respiration redox activity, thus adopting special form reprogramming. Medium from PDK4 + promotes the malignancy recipient cancer vitro,...
Abstract Aging is characterized by a progressive loss of physiological integrity, while cancer represents one the primary pathological factors that severely threaten human lifespan and healthspan. In clinical oncology, drug resistance limits efficacy most anticancer treatments, identification major mechanisms remains key to solve this challenging issue. Here, we highlight multifaceted senescence‐associated secretory phenotype (SASP), which comprises numerous soluble including amphiregulin...
Chemotherapy and radiation not only trigger cancer cell apoptosis but also damage stromal cells in the tumour microenvironment (TME), inducing a senescence-associated secretory phenotype (SASP) characterized by chronic secretion of diverse soluble factors. Here we report serine protease inhibitor Kazal type I (SPINK1), SASP factor produced human after genotoxic treatment. DNA causes SPINK1 expression engaging NF-κB C/EBP, while paracrine promotes aggressiveness particularly chemoresistance....
To investigate the molecular mechanism and clinical significance for an oncogenic role of enhancer zeste homolog 2 (EZH2) in renal cell carcinoma (RCC).Immunohistochemistry analyses EZH2, histone H3 trimethyl Lys27 (H3K27me3) E-cadherin were performed tumour tissue samples from 257 patients with RCC. Regulatory effects EZH2 on expression examined by quantitative real-time polymerase chain reaction, Western blot, chromatin immunoprecipitation assay immunohistochemical staining. Migration...
Photodynamic therapy (PDT) is a promising non-invasive therapeutic modality that has been proposed for treating prostate cancer, but the procedure associated with limited efficacy, tumor recurrence and photo-toxicity.In present study, we to develop novel multifunctional nano-platform targeted delivery of heat, reactive oxygen species (ROS) heat shock protein 90 (Hsp90) inhibitor simultaneously combination against cancer.This new combines two newly developed entities: 1) unique organic...
Mutations of SETD2 occur in 3% to 16% clear cell renal carcinoma cases. Previous studies identified an association between mutation and prognosis patients with nonmetastatic carcinoma. In this study we explored the prognostic predictive value expression metastatic treated targeted therapy.We retrospectively enrolled 138 sunitinib or sorafenib at a single institution from 2007 2014. was assessed by immunohistochemistry on tissue microarrays.After excluding those loss followup unavailable...
Abstract The tumor microenvironment (TME) represents a milieu enabling cancer cells to develop malignant properties, while concerted interactions between and stromal frequently shape an “activated/reprogramed” niche accelerate pathological progression. Here we report that soluble factor epiregulin (EREG) is produced by senescent cells, which non-cell-autonomously the senescence-associated secretory phenotype (SASP) upon DNA damage. Genotoxicity triggers EREG expression engaging NF-κB C/EBP,...
<b><i>Objectives:</i></b> To evaluate the efficacy and safety of mini- percutaneous nephrolithotomy (PCNL) in treatment large impacted proximal ureteral stones. <b><i>Methods:</i></b> We retrospectively reviewed outcomes 163 patients who underwent mini-PCNL between January 2006 August 2010. Mean age was 48.6 years mean stone size 18.4 mm. Hydronephrosis and/or hydroureterosis appeared all patients. In prone position, access (16-Fr sheath)...
Increased expression of EZH2 correlates with aggressive clinical behavior in various malignancies. In this study, we aim to investigate the and prognostic values activity tumor tissues improve risk stratification patients renal cell carcinoma after surgery. We analyzed its as indicated by H3K27me3 levels comprising 373 our institute. Outcome was assessed overall survival disease free using Kaplan-Meier analysis. Prognostic for outcomes were evaluated Cox regression used receiver operating...
No AccessJournal of UrologyAdult Urology1 Apr 2016A Prospective Randomized Controlled Trial the Efficacy External Physical Vibration Lithecbole after Extracorporeal Shock Wave Lithotripsy for a Lower Pole Renal Stone Less Than 2 cm Qilai Long, Jian Zhang, Zhibing Xu, Yanjun Zhu, Li Liu, Hang Wang, Jianming Guo, and Guomin Wang LongQilai Long , ZhangJian Zhang XuZhibing Xu ZhuYanjun Zhu LiuLi Liu WangHang GuoJianming Guo WangGuomin View All Author...
// Wei Xi 1, * , Li Liu Jiajun Wang Yu Xia 1 Qi Bai Ying Xiong Yang Qu Qilai Long Jiejie Xu 2 Jianming Guo Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China Biochemistry and Molecular Biology, School Basic Medical Sciences, These authors contributed equally to this work Correspondence to: Xu, email: jjxufdu@fudan.edu.cn Guo, guo.jianming@zs-hospital.sh.cn Keywords: ccRCC, C5aR, C5a-C5aR axis, prognosis, nomogram Received: September 20,...
Anaphylatoxin C5a, a potent pro-inflammatory peptide produced in the process of complement activation, was proved to have vital role tumor initiation and progession by previous investigations. However whether it could act as prognostic marker remains unknown. Here we retrospectively enrolled 272 ccRCC patients undergoing nephrectomy Zhongshan Hospital, Shanghai between 2005 2007. C5a level assessed immunohistochemistry its association with clinicopathologic features prognosis were evaluated....
// Yang Qu 1, * , Li Liu Jiajun Wang Wei Xi 1 Yu Xia Qi Bai Ying Xiong Qilai Long Jiejie Xu 2 Jianming Guo Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China Biochemistry and Molecular Biology, School Basic Medical Sciences, These authors have contributed equally to this work Correspondence to: Xu, email: jjxufdu@fudan.edu.cn Guo, guo.jianming@zs-hospital.sh.cn Keywords: clear-cell renal cell carcinoma, Dot1l, overall survival, prognostic biomarker, nomogram...
Aberrant sialylated carbohydrate synthesis is frequently noted in various cancers. Sialyltransferase ST3GAL-1, which adds a sialic acid an α-2,3 linkage to Gal β1,3 GalNAc, preforms important role modulating cellular behaviors. However, little known about prognostic significance of ST3GAL-1 clear cell renal carcinoma (ccRCC). In this study, we aimed investigate the sialyltransferase and its correlation with clinical outcomes patients ccRCC. A total 286 who underwent nephrectomy between 2005...
Abstract Dectin-1, a classical pattern-recognition receptor, was now identified as an important regulator in immune homeostasis and cancer immunity through its extensive ligands binding functions subsequent cytokines production. The aim of this study to assess the clinical significance dectin-1 expression 290 patients with clear cell renal carcinoma (ccRCC) immunohistochemistry on tissue microarrays. We found that predominantly expressed ccRCC cells, accordance several other online...
// Ying Xiong 1, * , Li Liu Yu Xia Jiajun Wang 1 Wei Xi Qi Bai Yang Qu Qilai Long Jiejie Xu 2 Jianming Guo Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China Biochemistry and Molecular Biology, School Basic Medical Sciences, These authors contributed equally to this work Correspondence to: Xu, email: jjxufdu@fudan.edu.cn Guo, guo.jianming@zs-hospital.sh.cn Keywords: c-type lectin-like receptor 2, clear cell renal carcinoma, prognostic factor, overall...
Purpose The purpose of this study was to report our approach partial nephrectomy (PN) using a supra-12th rib mini-flank incision. We compared mini-incision open (MI-OPN) with (OPN) and laparoscopic (LPN) verify whether MI-OPN can be an alternative OPN LPN. Methods This retrospective single-center including 194 patients who underwent between February 2005 December 2010. Demographic, perioperative, complication data were among the group, group LPN group. Results No statistical differences...
Clear cell renal carcinoma (ccRCC) features a Von Hippel-Lindau mutation, associated with hypoxia-inducible factor (HIF) imbalance. Copper transporter 1 (CTR1) may also promote tumor progression through the modulation of HIF pathway by copper. Therefore, present study explored prognostic effect CTR1 expression in patients ccRCC. A total 293 ccRCC that underwent nephrectomy were retrospectively enrolled. was assessed immunohistochemistry, and its association clinicopathological prognosis...