A5101560598- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Reconstructive Surgery and Microvascular Techniques
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Healthcare Systems and Public Health
- Prostate Cancer Diagnosis and Treatment
- Mechanisms of cancer metastasis
- Renal cell carcinoma treatment
- Ubiquitin and proteasome pathways
- Bone fractures and treatments
- Urinary Bladder and Prostate Research
- Central Venous Catheters and Hemodialysis
- Burn Injury Management and Outcomes
- Hormonal and reproductive studies
- Angiogenesis and VEGF in Cancer
- FOXO transcription factor regulation
- Hepatitis C virus research
- Peptidase Inhibition and Analysis
- Nerve Injury and Rehabilitation
- Biological Stains and Phytochemicals
Chongqing Medical University
2017-2025
Shanxi Agricultural University
2018-2025
Hanzhong Central Hospital
2013-2019
Twelfth Guangzhou City People's Hospital
2019
Hanzhong People's Hospital
2010-2014
Circular RNA (circRNA) has a significant impact on the maturation of skeletal muscle, although their precise functions within this framework remain largely uncharted. This study presents an investigation regulatory effect circAGGF1 myogenesis in myoblasts, including potential molecular mechanisms involved. It is revealed that facilitates differentiation myoblasts into other states while simultaneously enhancing manifestation type I muscle fibers. In vivo investigations with mice promotion...
Abstract Gastric cancer (GC) is a prevalent malignant of digestive system, identification novel diagnostic and prognostic biomarkers for GC urgently demanded. The aim this study was to determine potential long noncoding RNAs (lncRNAs) associated with the pathogenesis prognosis GC. Raw RNA microarray data (GSE53137, GSE70880, GSE99417) downloaded from Gene Expression Omnibus (GEO) database. Differentially expressed genes between adjacent normal gastric tissue samples were screened by an...
Abstract Betulinic acid (BA) exhibits cytotoxic activity against some cancer cells. However, the molecular mechanism of BA CRC cells was little reported. Here, we proved that elicited cells' growth inhibition and apoptosis in a dose-dependent manner. In addition, treatment induced autophagy via inhibiting AKT-MTOR signaling pathway. Inhibition by either administration autophagic inhibitor chloroquine or siRNA-mediated knockdown ATG5 could augment BA-induced apoptotic cell death as well...
ABSTRACT Given that more than 20% of patients with cT1 solid NSCLC showed nodal or extrathoracic metastasis, early detection metastasis is crucial and urgent for improving therapeutic planning patients' risk stratification in clinical practice. This study collected clinicopathological variables from the pulmonary nodule lung cancer database First Affiliated Hospital Chongqing Medical University, where early‐stage (cT1) solitary were evaluated 2018.11 to 2022.10. The random forest model...
In order to study the role of long non-coding RNAs (lncRNAs) in predicting platinum-based chemoresistance patients with high-grade serous ovarian carcinoma (HGS-OvCa), a=7-lncRNA signature was developed by analyzing 561 microarrays and 136 specimens from RNA-sequencing (RNA-seq) obtained online databases [odds ratio (OR), 2.859; P<0.0001]. The upregulated lncRNAs (RP11-126K1.6, ZBED3-AS1, RP11-439E19.10 RP11‑348N5.7) downregulated [RNF144A-AS1, growth arrest specific 5 (GAS5) F11-AS1]...
Abstract Gastric cancer (GC) is the fourth most common malignant neoplasm and second leading cause of death. Identification key molecular signaling pathways involved in gastric carcinogenesis progression facilitates early GC diagnosis development targeted therapies for advanced patients. Emerging evidence has revealed a close correlation between forkhead box (FOX) proteins development. However, prognostic significance S1 (FOXS1) patients with function FOXS1 remain undefined. In this study,...
Abstract Background Breast cancer (BC) is a common malignant tumor and its incidence mortality rates are ranked first among female cancers. So far, there has been no effective biomarkers for BC prognosis. Methods The DNA methylation data of was downloaded from Cancer Genome Atlas (TCGA), Gene Expression Omnibus, Functional ANnoTation Mammalian databases. RNA‐Seq clinical information patients were TCGA. R packages edgeR minfi used differentially methylated genes (DMGs) screening. Then, the...
Epigenetic alterations are crucial to oncogenesis and regulation of gene expression in non-small-cell lung carcinoma (NSCLC). DNA methylation (DNAm) biomarkers may provide molecular-level prediction relapse risk cancer. Identification optimal treatment is warranted for improving clinical management NSCLC patients. Using machine learning algorithm we identified 4 recurrence predictive CpG markers (cg00253681/ART4, cg00111503/KCNK9, cg02715629/FAM83A, cg03282991/C6orf10) constructed a score...
Identification of novel clinical biomarker in clear cell renal carcinoma (ccRCC) is warranted. Integrating transcriptome (n=1669), DNA methylation (n=577) and copy number data (n=832), we developed a method to identify driver biomarkers by analyzing the omics-level dynamics Epithelial-Mesenchymal Transition (EMT)-related genes ccRCC. We first identified 504 expression dynamic changed involved ccRCC-associated key pathways such as EMT, cycle, EGFR PI3K/AKT signaling. Further analysis 229 (90...
Purpose: Gastric cancer (GC) is the fifth most common tumor in world, and patients with GC have a poor prognosis. This study aimed to explore biological influence mechanism of LINC01272 GC. Materials Methods: Using bioinformatic analyses, we investigated expression TCGA database predicted functions Then, detected cell lines, tissues, corresponding normal tissues using real-time polymerase chain reaction (RT-PCR). Finally, explored migration invasion ability by wound-healing Transwell assays...
In order to explore the molecular mechanisms behind pathogenesis of acute liver failure (ALF) associated with hepatitis B virus (HBV) infection, present study aimed identify potential key genes and pathways involved using samples from patients HBV-associated ALF. The GSE38941 array dataset was downloaded Gene Expression Omnibus database, differentially expressed (DEGs) between 10 healthy donors 17 specimens 4 ALF were analyzed Linear Models for Microarray Data package. Ontology KEGG pathway...
<b>Background</b> Reconstruction of cervicofacial scarring continues to present challenges for surgical treatment. Here we our clinical experience in repairing using pre-expanded thoracodorsal artery perforator flaps. <b>Methods</b> From January 2007 December 2012, 15 patients were treated severe scarring. In the first stage, expanders implanted subcutaneously zone nourished by perforators. The expansion generally took 3 6 months. second cicatricial contracture was released and secondary...
Prostate cancer (PC) is a commonly diagnosed malignancy in males, especially the western hemisphere. The extensive use of multiple biomarkers plays an important role diagnosis and prognosis PC. However, accuracy for PC needs to be urgently improved. This study aimed identify novel prognostic biomarker Differentially methylated CpG sites were identified from GSE76938 dataset ( https://www.ncbi.nlm.nih.gov/geo/ ) using R software version 3.1.4. Four significant on SLCO4C1 gene found closely...
Prostate cancer (PCa) metastasis is considered the leading cause of death in males. Therapeutic strategies and diagnosis for stage-specific PCa have not been well understood. Rho guanine nucleotide exchange factor 38 (ARHGEF38) related to tumor cell polarization frequently expressed PCa. Microarray data were downloaded from GEO TCGA databases. A total 243 DEGs screened, which, 32 genes upregulated. The results enrichment analysis showed participation these pathway. ARHGEF38 was significantly...
Gastric cancer (GC) is a common type of cancer, and identification novel diagnostic biomarkers associated with this disease important. The present study aimed to identify the prognosis GC, using an integrated bioinformatics approach. Differentially expressed long non‑coding RNAs (lncRNAs) GC were identified Gene Expression Omnibus datasets (GSE58828, GSE72305 GSE99416) Cancer Genome Atlas database. A competing endogenous RNA network that incorporated five lncRNAs [long intergenic non‑protein...
The aim of this research was to screen candidate genes affecting growth traits in pigs by studying the difference expression (DEGs) between longissimus dorsi Large White (LW) and Mashen (MS) pigs. RNA-sequencing (RNA-seq) technology applied analyse transcriptomes from six two pig breeds (LW MS). Based on sequencing, DEGs were screened, functional annotation enrichment analysis performed. results showed that 697 different significant obtained (p < 0.05, FDR <0.05 |FC| ≥ 2). Gene Ontology (GO)...
Patients with clear cell renal carcinoma (ccRCC) often relapse after nephrectomy, even for those localized or locally advanced diseases. However, ideal prognostic biomarkers specifically localized, advanced, and metastatic ccRCC are inadequate. In this paper, we systematically identified potential disease-free prognosis of patients ccRCC. The expression clinical data Cancer Genome Atlas (TCGA, n = 603) international cancer genomics consortium (ICGC, 392) were leveraged to identify long...
The extensive spatial genomic intratumor heterogeneity (ITH) in liver cancer hindered treatment development and limited biomarker design. Early events that drive tumor malignant transformation founder cells are clonally present all cell populations, which provide stable biomarkers for the localization of patients’ prognosis. In study, we identified recurrently clonal somatic mutations copy number alterations (CNAs) (893 6,617 CNAs) 353 patients from Cancer Genome Atlas (TCGA) evaluated their...
It is difficult to repair knee deep burn wounds in elderly patients. In this study, we observed the therapeutic effects of descending genicular artery-saphenous artery perforator flaps on Between December 2013 and February 2018, repaired third-degree using 20 × 12 cm 23 13 56 For patella patellar ligament with complete necrosis, were completely removed, whereas for partial necrotic parts removed first. The donor area was intermediate thickness free skin graft. patients 76- 85 years' old all...
Atrial fibrosis plays a critical role in the pathogenesis of atrial fibrillation (AF). Monocyte chemotactic protein-induced protein-1 (MCPIP1), recognized as functional ribonuclease (RNase), exacerbates cardiac remodeling and contributes to range cardiovascular diseases. However, involvement MCPIP1 development AF, along with its underlying biological mechanisms, remains poorly understood. This study demonstrated that knockdown significantly reduced AF inducibility, decreased left diameter,...
Abstract It is difficult to repair large skull and dural defects. We observed the therapeutic effects of anterolateral thigh flaps with vascular fascia lata for repairing From December 2008 June 2019, we repaired defects 28 cases including 12 scalp malignant tumor 16 requiring removal titanium mesh which had been once placed due craniocerebral trauma. The invaded full-thickness in cases; cervical lymph nodes, dura mater or brain tissue 3 cases. In tumor, cm × 9 22 18 7 15 after radical...