A5051034017- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Medicinal Plants and Neuroprotection
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Chronic Lymphocytic Leukemia Research
- Obstructive Sleep Apnea Research
- Biochemical effects in animals
- Autophagy in Disease and Therapy
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Bioactive Compounds and Antitumor Agents
- Antioxidants, Aging, Portulaca oleracea
- Genetic Associations and Epidemiology
- Traditional Chinese Medicine Analysis
- Circular RNAs in diseases
- RNA modifications and cancer
- Biochemical and Molecular Research
- Cytokine Signaling Pathways and Interactions
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Cancer-related Molecular Pathways
Fujian University of Traditional Chinese Medicine
2025
Key Laboratory of Guangdong Province
2024
Southern Medical University
2024
Chinese University of Hong Kong
2018-2021
Southwest University
2017-2018
Baylor College of Medicine
2009
Z-Ligustilide (Z-LIG) is a major component in Rhizoma Chuanxiong, which has been traditionally used as health food supplement for the prevention of cerebrovascular disease China. This study investigates ability intranasal Z-LIG pretreatment to enhance protection against neuronal damage rats with middle cerebral artery occlusion (MCAO) and role cellular stress response mechanisms Nrf2 HSP70. significantly mitigated infarct volume, neurological dysfunction, blood-brain barrier disruption,...
Background: To further understand the complex relationship between Obstructive Sleep Apnea (OSA) and ischemic stroke, this study explores role of genetic factors in comorbidity these two conditions. Methods: Based on large-scale available Genome-Wide Association Studies (GWAS) for OSA we conducted a multi-level cross-trait analysis. First, utilized Linkage Disequilibrium Score Regression (LDSC) to analyze correlation diseases. Subsequently, performed analysis identify pleiotropic Single...
// Hui Ma 1, * , Li Guojun Dou 1 Chengqiang Wang Juan He Mingxia Wu and Hongyi Qi College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China These authors have contributed equally to this work Correspondence to: Qi, email: hongyiqi@swu.edu.cn Keywords: Z-ligustilide, tamoxifen, ERα negative breast cancer, MTA1, histone modification Received: January 13, 2017 Accepted: March 02, Published: 22, ABSTRACT Emerging evidence indicates epigenetic represses estrogen receptor α...
β-asarone, the main component in volatile oil of Acori tatarinowii Rhizoma, has been found to possess antitumor activity. However, its effect and mechanisms against tumor invasion epithelial-mesenchymal transition (EMT) are still unclear. In this study, no or less cytotoxicity was caused by β-asarone within 0-120 μM human glioma U251 cells for 48 h. (30 60 μM) inhibited migration wound healing assay, suppressed Boyden chamber adhesion onto Matrigel. Moreover, EMT with up-regulation...
Abstract #34 Background: Activating mutations of PI3 kinase (PIK3CA) and PTEN loss may be associated with trastuzumab resistance. Trastuzumab, a HER2 humanized monoclonal antibody, lapatinib, an EGFR/HER2 tyrosine inhibitor are both established treatments. Greater understanding the cellular response to or lapatinib is needed tailor targeted therapy for individual patients identify those less likely benefit. Material Methods: We performed two sequential neoadjuvant clinical trials in HER-2...
HnRNP A2/B1 has been found to be an oncogenic protein strongly related the growth of human glioma cells. Herein, β-asarone, main component in volatile oil Acori tatarinowii Rhizoma, inhibited cell viability, proliferation, and colony formation ability U251 Moreover, β-asarone induced apoptosis cycle arrest at G1 phase. Notably, suppressed expression hnRNP hnRNPA2/B1 overexpression remarkably reversed β-asarone-mediated arrest. Importantly, promoted alternative splicing Bcl-x by enhancing...
Gefitinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) approved for first-line treatment of non-small cell lung cancer (NSCLC) with sensitizing EGFR mutations. However, NSCLC patients bearing mutant KRAS are inherently unresponsive to gefitinib. Defective autophagy was proposed mediate resistance EGFR-TKIs. In this study, the reversal primary gefitinib in by putative inducers investigated. A few were investigated cells harboring or Quantitative real-time PCR...
Abstract Aim: This study investigated the inhibition of proliferation and invasiveness colorectal cancer (CRC) by niclosamide via targeting secreted Frizzled-related protein 1 (SFRP1) Wnt/beta-catenin signaling pathway. Background: CRC is third most common worldwide. Aberrant activation various pathways in leads to its poor response chemotherapy. Hyperactivation pathway known drive cell proliferation, invasion, migration CRC. Epigenetic silencing extracellular Wnt inhibitors, such as...