A5042037298- Calpain Protease Function and Regulation
- Cell death mechanisms and regulation
- Spinal Cord Injury Research
- Retinoids in leukemia and cellular processes
- Nerve injury and regeneration
- interferon and immune responses
- Neuroblastoma Research and Treatments
- RNA regulation and disease
- Neuroscience and Neuropharmacology Research
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related Molecular Pathways
- Pregnancy-related medical research
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Venomous Animal Envenomation and Studies
- Parkinson's Disease Mechanisms and Treatments
- Estrogen and related hormone effects
- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Menopause: Health Impacts and Treatments
- Histone Deacetylase Inhibitors Research
- Garlic and Onion Studies
- NF-κB Signaling Pathways
University of South Carolina
2016-2025
National Institute of Neurosciences & Hospital
2024
Bipar
2016
Block Center
2015
Medical University of South Carolina
2001-2010
Sanford Burnham Prebys Medical Discovery Institute
1997
Emory University
1996-1997
Discovery Institute
1997
Palmetto Hematology Oncology
1995
Human glioblastoma is a deadly brain cancer that continues to defy all current therapeutic strategies. The authors induced apoptosis in human T98G and U87MG cells after treatment with apigenin, (-)-epigallocatechin, (-)-epigallocatechin-3-gallate (EGCG), genistein, which did not induce normal astrocytes.Induction of was examined using Wright staining ApopTag assay. Production reactive oxygen species (ROS) increase intracellular free Ca(2+) were measured by fluorescent probes. Analysis mRNA...
Garlic-derived organosulfur compounds such as diallyl sulfide (DAS), disulfide (DADS), and trisulfide (DATS) provide significant protection against carcinogenesis.Dose-dependent cytotoxic effects of the garlic (DAS, DADS, DATS) were tested in human glioblastoma T98G U87MG cells. Wright staining ApopTag assay confirmed induction apoptosis. Measurements showed that production reactive oxygen species (ROS) an increase intracellular free [Ca(2+)] promoted Western blot analysis indicated...
Neuroimmunology and Neuroinflammation is an open access journal, with focuses on neuroimmunology neuroinflammation research, coverage extending to other basic clinical studies related neuroscience.
Abstract Spinal cord injury (SCI) is a devastating neurologic with functional deficits for which the only currently recommended pharmacotherapy high‐dose methylprednisolone, has limited efficacy. Estrogen multiactive steroid that shown antiinflammatory and antioxidant effects, estrogen may modulate intracellular Ca 2+ attenuate apoptosis. For this study, male rats were divided into three groups. Sham group animals received laminectomy at T12. Injured both 40 g · cm force SCI. Estrogen‐group...
Abstract: Multiple investigations in vivo have shown that melatonin (MEL) has a neuroprotective effect the treatment of spinal cord injury (SCI). This study investigates role MEL as an intervening agent for ameliorating Ca 2+ ‐mediated events, including activation calpain, following its administration to rats sustaining experimental SCI. Calpain, ‐dependent neutral protease, is known be involved pathogenesis Rats were injured using standard weight‐drop method induced moderately severe (40...