A5036225281- Head and Neck Cancer Studies
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Advanced Radiotherapy Techniques
- Prostate Cancer Treatment and Research
- Head and Neck Surgical Oncology
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Management of metastatic bone disease
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Crystallization and Solubility Studies
- Cutaneous Melanoma Detection and Management
- X-ray Diffraction in Crystallography
- Salivary Gland Tumors Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Neuroblastoma Research and Treatments
- Spinal Fractures and Fixation Techniques
- Nerve Injury and Rehabilitation
- Cancer, Hypoxia, and Metabolism
- Endometrial and Cervical Cancer Treatments
Huntsman Cancer Institute
2017-2025
University of Utah
2017-2024
St. Luke's Mountain States Tumor Institute
2014-2021
University of Wisconsin–Madison
2010-2017
Varian Medical Systems (United States)
2013
UW Health University Hospital
2012-2013
University of Maryland, Baltimore
2013
University of Wisconsin Carbone Cancer Center
2012
Cornell University
2007
University of Illinois Urbana-Champaign
2005
The NCCN Guidelines for Central Nervous System (CNS) Cancers focus on management of the following adult CNS cancers: glioma (WHO grade 1, WHO 2–3 oligodendroglioma [1p19q codeleted, IDH- mutant], 2–4 mutant astrocytoma, 4 glioblastoma), intracranial and spinal ependymomas, medulloblastoma, limited extensive brain metastases, leptomeningeal non–AIDS-related primary lymphomas, metastatic spine tumors, meningiomas, cord tumors. information contained in algorithms principles sections are...
Purpose Local failure rates after radiation therapy (RT) for locally advanced non–small-cell lung cancer (NSCLC) remain high. Consequently, RT dose intensification strategies continue to be explored, including hypofractionation, which allows acceleration that could potentially improve outcomes. The maximum-tolerated (MTD) with dose-escalated hypofractionation has not been adequately defined. Patients and Methods Seventy-nine patients NSCLC were enrolled on a prospective single-institution...
A miniaturized lead sensor has been developed by combining a lead-specific DNAzyme with microfabricated device containing network of microfluidic channels that are fluidically coupled via nanocapillary array interconnect. construct, selective for cleavage in the presence Pb2+ and derivatized fluorophore (quencher) at 5' (3') end substrate enzyme strands, respectively, forms molecular beacon is used as recognition element. The membrane interconnect to manipulate fluid flows deliver...
Adaptive Radiotherapy aims to identify anatomical deviations during a radiotherapy course and modify the treatment plan maintain objectives. This requires regions of interest (ROIs) be defined using most recent imaging data. study investigates clinical utility deformable image registration (DIR) automatically propagate ROIs. Target (GTV) organ-at-risk (OAR) ROIs were non-rigidly propagated from planning CT scan per-treatment for 22 patients. Propagated quantitatively compared with expert...
Patients with advanced melanoma who progress on standard-dose ipilimumab (Ipi) + nivolumab continue to have poor prognosis. Studies support a dose–response activity of Ipi, and one promising combination is Ipi 10 mg/kg (Ipi10) temozolomide (TMZ). We performed retrospective cohort analysis patients treated Ipi10 TMZ in the immunotherapy refractory/resistant setting (n = 6, all progressed after prior nivolumab), using similar Ipi3 6) as comparison. Molecular profiling by whole-exome sequencing...
Prolonged radiation treatment time (RTT) in head and neck squamous cell carcinoma (HNSCC) is associated with inferior tumor control patients treated therapy (RT) alone. However, the significance of prolonged RTT concurrent chemotherapy less clear.We reviewed outcomes for 171 primary HNSCC curative intent RT drug from 2001 to 2009. The effects other variables on local survival were analyzed.Patients >7 weeks had a significantly increased risk failure (hazard ratio [HR], 2.6; p = .018) death...
Understanding the influence of molecular environment on phospholipids is important in time-of-flight secondary ion mass spectrometry (TOF-SIMS) studies complex systems such as cellular membranes. Varying model membrane Langmuir−Blodgett (LB) films shown to affect TOF-SIMS signal films. The a LB film dipalmitoylphosphatidylcholine (DPPC) changed by varying density, sample substrate, and addition cholesterol. An increase density results decrease headgroup fragment at mass-to-charge ratio 184...
Abstract Background The risk of recurrence is overestimated by the Kaplan–Meier method when competing events, such as death without recurrence, are present. Such overestimation can be avoided using Aalen-Johansen method, which a direct extension that accounts for events. Meningiomas commonly occur in older individuals and have slow-growing properties, thereby warranting analysis. extent to events considered meningioma literature unknown, consequences incorrect methodologies analysis not been...
Lymph node yield in therapeutic neck dissection is clinically significant and incompletely studied. We quantified based on extent of presence preoperative radiation. also evaluated factors affecting incidence extracapsular spread (ECS).Retrospective review 499 patients undergoing dissection; 414 met inclusion criteria were divided into 2 groups: alone or before radiation (surgery first: 280 patients; 385 dissections) primary surgery (radiation 134 157 dissections). Node relative to levels...
Abstract Background Adult head and neck (H&N) sarcomas are a rare malignancy with limited data delineating the role of postoperative radiotherapy (PORT), particularly for positive surgical margin. There no randomized trials supporting use PORT, therefore treatment trends vary between institutions. A margin predicts recurrence poor survival outcomes. This study uses National Cancer Database (NCDB) to investigate whether PORT improves overall (OS) in adult H&N how utilization has...
To describe the safety and efficacy of single-fraction hypofractionated image-guided radiotherapy techniques for treatment large liver tumors.Forty-six patients, with 50 tumors (10 primary tumors, 40 metastases) from March 2004 to 2011 were reviewed. The maximal tumor diameter ranged 1.2 11.3 cm (median, 4.2 cm). Eighty-seven percent patients received prior systemic chemotherapy. Fifty-nine had invasive local therapy including surgery, ablation, or embolization. Twenty-five lesions treated...
We examined the impact of brachytherapy boost (BB) and external beam radiotherapy (EBRT) dose-escalation on overall survival (OS) for women with cervical cancer receiving postoperative chemotherapy radiation (CRT) a positive margin following hysterectomy.