A5014962360- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Brain Tumor Detection and Classification
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Musculoskeletal pain and rehabilitation
- Epilepsy research and treatment
- Radiomics and Machine Learning in Medical Imaging
- EEG and Brain-Computer Interfaces
- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Chemometric Analyses
- Treatment of Major Depression
- Pain Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Neuroscience and Neural Engineering
- Glioma Diagnosis and Treatment
- Pain Management and Treatment
- Atomic and Subatomic Physics Research
- Bone and Joint Diseases
- Machine Learning in Healthcare
- Bone health and osteoporosis research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pain Management and Placebo Effect
University of California, Los Angeles
2017-2024
Twitter (United States)
2022
Committee on Publication Ethics
2017
University of Thessaly
2009-2014
The success of deep brain stimulation (DBS) for treating Parkinson's disease has led to its application several other disorders, including treatment-resistant depression. Results with DBS depression have been heterogeneous, inconsistencies largely driven by incomplete understanding the networks regulating mood, especially on an individual basis. We report results from first subject treated using approach that incorporates intracranial recordings personalize network behavior and response...
BackgroundThe efficacy of psychiatric DBS is thought to be driven by the connectivity stimulation targets with mood-relevant fronto-temporal networks, which typically evaluated using diffusion-weighted tractography.ObjectiveLeverage intracranial electrophysiology recordings better predict circuit-wide effects neuromodulation white matter targets. We hypothesize strong convergence between tractography-predicted structural and stimulation-induced electrophysiological responses.MethodsEvoked...
Background: Epilepsy is a widespread neurologic disorder and almost one-third of patients suffer from drug-resistant epilepsy (DRE). Neuromodulation targeting the centromediannucleus thalamus (CM) has been showing promising results for with generalized DRE who are not surgical candidates. Recently, effect CM- deep brain stimulation (DBS) in was investigated Electrical Stimulation Thalamus Lennox–Gastaut phenotype (ESTEL) trial, monocentric randomized-controlled study. The same authors...
Magnetic Resonance-guided Focused UltraSound (MRgFUS) offers an incisionless approach to treat essential tremor (ET). Due lack of evident internal anatomy on traditional structural imaging, indirect targeting must still be used localize the lesion. Here, we investigate potential predictive value probabilistic tractography guided thalamic by defining how tractography-defined targets, lesion size and location, clinical outcomes interrelate. MR imaging from 12 ET patients that underwent MRgFUS...
Purpose . To evaluate the diagnostic value of 3T 1 H-MRS in grading cerebral gliomas using short and long echo times. Methods 1H-MRS was performed on 71 patients with untreated gliomas. Metabolite ratios NAA/Cr, Cho/Cr, Cho/NAA, mI/Cr were calculated for TE compared between low high grade Lipids qualitatively evaluated. ROC analysis to obtain cut-off values metabolic presenting statistical difference two glioma grades. Results Intratumoral Cho/Cr at both TEs Cho/NAA significantly different...
Abstract Objective. Therapeutic efficacy of deep brain stimulation (DBS) in both established and emerging indications, is highly dependent on accurate lead placement optimized clinical programming. The latter relies clinicians’ experience to search among available sets parameters can be limited by the time constraints practice. Recent innovations device technology have expanded number possible electrode configurations parameter clinicians, amplifying challenge constraints. We hypothesize...
Abstract The subcallosal cingulate (SCC) area is a putative hub in the brain network underlying depression. Deep stimulation (DBS) targeting particular subregion of SCC, identified as intersection forceps minor (FM), uncinate fasciculus (UCF), cingulum and fronto‐striatal fiber bundles, may be critical to therapeutic response patients with severe, treatment‐resistant forms major depressive disorder (MDD). pattern variability white matter anatomy organization within SCC has not been...
Diminished motivation to pursue and obtain primary secondary rewards has been demonstrated in anorexia nervosa (AN). However, the neurobehavioral mechanisms underlying behavioral activation component of aberrant reward remains incompletely understood. This work aims explore this underexplored facet AN. We recruited female adolescents with AN, restricting type (n = 32) a healthy control group 28). All participants underwent functional magnetic resonance imaging (fMRI) while performing...
Deep brain stimulation (DBS) studies have shown that of the motor segment thalamus based on probabilistic tractography is predictive improvement in essential tremor (ET). However, methods are computationally demanding, requiring need for alternative use clinical setting. The purpose this study was to compare vs deterministic connectivity-based targeting patients with ET. Probabilistic and were retrospectively applied diffusion-weighted data sets 36 refractory precentral gyrus selected as...
Anesthetics are believed to alter functional connectivity across brain regions. However, network-level analyses of anesthesia, particularly in humans, sparse. The authors hypothesized that propofol-induced loss consciousness results disconnection human sensorimotor cortices underlying the volitional motor responses.The recorded local field potentials from patients with Parkinson disease (N = 12) and essential tremor 7) undergoing deep stimulation surgery, before after consciousness. Local...
Deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM-DBS) is a highly successful treatment for medication-refractory essential tremor (ET). Clinical outcomes are dependent on accurate targeting. Here, we aim to develop framework connectivity-guided DBS targeting by evaluating probabilistic tractography and clinical response at both initial programming (IP) follow-up (CF). Magnetic resonance imaging were evaluated in 23 ET patients who treated VIM-DBS University California...
Depression is a heterogeneous clinical syndrome prevalent in patients with Parkinson disease (PD) that remains incompletely understood. Further, the differences biomarkers of depression PD and non-PD are unclear. The subcallosal cingulate cortex (SCC) its connections have been implicated pathophysiology major depressive disorder (MDD). Diffusion tensor imaging (DTI) provides tool to quantify MDD-related structural abnormalities underlying symptoms PD. Diffusion-weighted magnetic resonance...
BACKGROUND AND OBJECTIVES: Recent advances in stereotactic and functional neurosurgery have brought forth the stereo-electroencephalography approach which allows deeper interrogation characterization of contributions deep structures to neural affective functioning. We argue that this can should be bear on notoriously intractable issue defining pathophysiology refractory psychiatric disorders developing patient-specific optimized stimulation therapies. METHODS: developed a suite methods for...
OBJECTIVE Essential tremor (ET) is the most common movement disorder. Deep brain stimulation (DBS) targeting ventral intermediate nucleus (VIM) known to improve symptoms in patients with medication-resistant ET. However, clinical effectiveness of VIM-DBS may vary, and other targets have been proposed. The authors aimed investigate whether same anatomical structure responsible for control both immediately after at later follow-up evaluations. METHODS Of 68 electrodes from 41 ET, mapped...