A5046606121- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Treatment of Major Depression
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
Boston Scientific (United States)
2016-2022
Boston Scientific (Netherlands)
2022
BackgroundThe efficacy of psychiatric DBS is thought to be driven by the connectivity stimulation targets with mood-relevant fronto-temporal networks, which typically evaluated using diffusion-weighted tractography.ObjectiveLeverage intracranial electrophysiology recordings better predict circuit-wide effects neuromodulation white matter targets. We hypothesize strong convergence between tractography-predicted structural and stimulation-induced electrophysiological responses.MethodsEvoked...
Abstract Objective. Therapeutic efficacy of deep brain stimulation (DBS) in both established and emerging indications, is highly dependent on accurate lead placement optimized clinical programming. The latter relies clinicians’ experience to search among available sets parameters can be limited by the time constraints practice. Recent innovations device technology have expanded number possible electrode configurations parameter clinicians, amplifying challenge constraints. We hypothesize...
INTRODUCTION: Directional deep brain stimulation (DBS) leads designed to preferentially stimulate structures radially about the DBS lead are currently under development. Recent publications have demonstrated ability of these obtain directional effects during acute testing in patients. Here we will use computational modeling demonstrate that combining with Multiple Independent Current Control (MICC) offer additional control over shape Volume Tissue Activated (VTA). METHODS: A finite element...
Abstract Objective Therapeutic efficacy of deep brain stimulation (DBS) in both established and emerging indications, is highly dependent on accurate lead placement optimized clinical programming. The latter relies clinicians’ experience to search among available sets parameters can be limited by the time constraints practice. Recent innovations device technology have expanded number possible electrode configurations parameter clinicians, amplifying challenge constraints. We hypothesize that...
On the Cover: Example of evoked potential and streamline analysis for a single stimulation volume.Two treatment-resistant depression patients underwent neurosurgical treatment involving DBS.We compare tractography from pre-surgical MRI to postsurgical in vivo recordings.(A) Given volume interest as Right SCC monopolar stacked segmented contacts 4 7, (red sphere) diffusion whole brain is performed intersection with sEEG contact (Left OFC 3) calculated.(B) 315 single-pulse trials are applied...