A5017771473- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Treatment of Major Depression
- Neuroscience and Neural Engineering
- Genetic Neurodegenerative Diseases
- Peroxisome Proliferator-Activated Receptors
- Neural dynamics and brain function
- Musculoskeletal pain and rehabilitation
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Immune Cell Function and Interaction
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Vagus Nerve Stimulation Research
- Obsessive-Compulsive Spectrum Disorders
- Advanced MRI Techniques and Applications
- Personality Disorders and Psychopathology
- Pain Mechanisms and Treatments
- Innovations in Medical Education
- Reproductive tract infections research
Emory University
2016-2025
Temple University
2022
University of Wisconsin–Madison
2019
Queen's University Belfast
2018
University of Zurich
2018
University Hospital Bonn
2018
Universidade de São Paulo
2018
Charité - Universitätsmedizin Berlin
2018
Rutgers, The State University of New Jersey
2018
Trinity College Dublin
2018
Deep brain stimulation of the subcallosal cingulate (SCC DBS) has been studied as a potential treatment for severe and refractory major depressive disorder since 2005. The authors used an open-label, long-term follow-up design to examine participants enrolled in clinical trial SCC DBS treatment-resistant depression.Long-term outcome data were collected 28 patients (20 with seven bipolar II disorder; one patient depression subgroup was later reclassified having disorder) receiving 4-8...
Abstract Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term symptom relief for treatment-resistant depression (TRD) 1 . However, achieving stable recovery is unpredictable 2 , typically requiring trial-and-error adjustments due to individual trajectories and subjective reporting 3 We currently lack objective brain-based biomarkers guide clinical decisions by distinguishing natural transient mood fluctuations from situations intervention. To address this...
Peroxisome proliferator–activated receptor (PPAR)α is a nuclear that mediates gender differences in lipid metabolism. PPARα also functions to control inflammatory responses by repressing the activity of factor κB (NF-κB) and c-jun immune cells. Because situated at crossroads regulation, we hypothesized this gene may mediate sex development T cell–mediated autoimmune disease. We show more abundant male as compared with female CD4+ cells its expression sensitive androgen levels. Genetic...
Movement disorders of basal ganglia origin may arise from abnormalities in synchronized oscillatory activity a network that includes the ganglia, thalamus and motor cortices. In humans, much has been learned study local field potentials recorded temporarily externalized deep brain stimulator electrodes. These studies have led to theory Parkinson's disease characteristic alterations beta frequency band (13-30 Hz) ganglia-thalamocortical network. However, different rarely compared using...
The in vitro activities of tinidazole and metronidazole against Trichomonas vaginalis isolates clinically resistant to were compared. Minimal lethal concentrations (MLCs) significantly lower than MLCs metronidazole. Increased resistance correlated with increased resistance. These data support a role for the treatment trichomoniasis.
The number of depressed patients treated with deep brain stimulation (DBS) is relatively small. However, experience this intervention now spans more than 10 years at some centers, study subjects typically monitored closely. Here we describe one center's evolving impressions regarding optimal patient selection for DBS the subcallosal cingulate (SCC) as well observations short- and long-term patterns in antidepressant response mood reactivity. A consistent time course therapeutic distinct...
Subcallosal cingulate cortex deep brain stimulation (SCC-DBS) is an experimental therapy for treatment-resistant depression (TRD). Refinement and optimization of SCC-DBS will benefit from increased study SCC electrophysiology in context ongoing high-frequency therapy. The objective was a 7-mo observation frequency-domain 1/f slope off-stimulation local field potentials (SCC-LFPs) alongside standardized measurements severity 4 patients undergoing SCC-DBS. implanted bilaterally with combined...
This article proposes a framework for managing the behavioral health impacts of COVID-19 global pandemic. aligns and should be integrated with an existing public pandemic intervals model. It includes six phases response strategy: preplanning, readiness, mobilization, intervention, continuation, amelioration. The ways specialists can capitalize on their competence in leadership, prevention, education, service, research, advocacy domains within each phase are articulated. Behavioral expertise...
Abstract Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) is a promising intervention for treatment-resistant depression (TRD). Despite failure clinical trial, multiple case series have described encouraging results, especially with introduction improved surgical protocols. Recent evidence further suggests that tractography targeting and intraoperative exposure to enhances early antidepressant effects evolve ongoing chronic DBS. Accelerating treatment gains critical care this...
The study evaluated the effects of an intensive case management model on clients' use inpatient and outpatient psychiatric care costs care.Ninety clients a county mental health system who were frequent users services randomly assigned to either group, traditional or control group received no particular services. Outcome variables measured over two-year period number units used by in private facilities various types care, including day treatment emergency unit.Clients had fewer days reduced...
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> Major depressive disorder (MDD) is a common psychiatric that leads to persistent changes in mood and interest among other signs symptoms. We hypothesized convolutional neural network (CNN) based automated facial expression recognition, pre-trained on an enormous auxiliary public dataset, could provide improve generalizable approach MDD automatic assessment from videos, classify...
Highlights –Patients with treatment-resistant depression (TRD) referred for ECT may experience anxiety. – Little is known about anxiety symptom changes during an course. Retrospective data was analyzed 117 TRD patients acute Anxiety symptoms improved but not as robustly depressive symptoms. More treatment predicted worse antidepressant outcomes. Major disorder (MDD) one of the most common psychiatric disorders in both specialist and general medical practice. 1 Symptoms are likely to...
Introduction Deep brain stimulation (DBS) is a promising treatment for refractory depression, utilizing surgically implanted electrodes to stimulate specific anatomical targets within the brain. However, limitations of patient-reported and clinician-administered mood assessments pose obstacles in evaluating DBS efficacy. In this study, we investigated whether an affective bias task, which leverages inherent negative interpretation seen individuals with could serve as reliable measure changes...
Major Depressive Disorder (MDD) is a common psychiatric illness. Automatically classifying depression severity using audio analysis can help clinical management decisions during Deep Brain Stimulation (DBS) treatment of MDD patients. Leveraging the link between short-term emotions and long-term depressed mood states, we build our predictive model on top emotion-based features. Because acquiring emotion labels patients challenging task, propose to use an auxiliary dataset train Neural Network...
Background: High-frequency Deep Brain Stimulation (DBS) of the subcallosal cingulate (SCC) region is an emerging strategy for treatment-resistant depression (TRD). This study examined changes in SCC local field potentials (LFPs). The LFPs were recorded from DBS leads following transient, unilateral stimulation at neuroimaging-defined optimal electrode contact. goal was identifying a putative electrophysiological measure target engagement during implantation. Methods: Fourteen consecutive...
Abstract Deep brain stimulation (DBS) to the subcallosal cingulate cortex (SCC) is an emerging therapy for treatment resistant depression. Precision targeting of specific white matter fibers now central model SCC DBS efficacy. A method confirm target engagement needed reduce procedural variance across providers and optimize parameters individual patients. We examined reliability a novel cortical evoked response that time‐locked 2 Hz pulse shows propagation signal from target. The was...
We used several metrics of variability to extract unsupervised features from video recordings patients before and after deep brain stimulation (DBS) treatment for major depressive disorder (MDD). Our goal was quantify the effects on facial expressivity. Multiscale entropy (MSE) capture temporal in pixel intensity level at multiple time-scales. A dynamic latent variable model (DLVM) learn a low dimensional (D = 20) set factors that explain observed covariance across high-dimensional pixels (M...
Major depressive disorder is a common psychiatric illness. At present, there are no objective, non-verbal, automated markers that can reliably track treatment response. Here, we explore the use of video analysis facial expressivity in cohort severely depressed patients before and after deep brain stimulation (DBS), an experimental for depression. We introduced set variability measurements to obtain unsupervised features from muted recordings, which were then leveraged build predictive models...