A5011494197- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
Duke University
2022-2024
Case Western Reserve University
2021
University of Twente
2021
Deep brain stimulation is an effective treatment for Parkinson's disease but can be complicated by side-effects such as cognitive decline. There often a delay before this side-effect apparent and the mechanism unknown, making it difficult to identify patients at risk or select appropriate deep settings. Here, we test whether connectivity between site other regions associated with decline following stimulation. First, studied unique patient cohort subthalamic (n = 10) where reprogramming...
Abstract Background Efficacy of deep brain stimulation (DBS) relies on accurate lead placement as well optimization the parameters. Although clinical software tools are now available, programming still largely a monopolar review, tedious process for both patients and programmers. Objective This study investigates safety feasibility prospective automated connectomic DBS (automated [ACP]), focusing recruitment specific white matter pathways. Methods After implantation, detailed model in...
Deep brain stimulation (DBS) is an established clinical therapy, and directional DBS electrode designs are now commonly used in practice. Directional leads have the ability to increase therapeutic window of stimulation, but they also complexity programming. Therefore, computational models become available software tools that designed assist identification settings. However, details how model implemented can influence predictions software. The goal this study was compare different methods for...