A5044094465- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- Acute Ischemic Stroke Management
- Fetal and Pediatric Neurological Disorders
- Stroke Rehabilitation and Recovery
- Anesthesia and Neurotoxicity Research
- Prenatal Screening and Diagnostics
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Optical Imaging and Spectroscopy Techniques
- Spinal Dysraphism and Malformations
- Neonatal and fetal brain pathology
- Neural dynamics and brain function
- Neurological and metabolic disorders
Emory University
2018-2025
Imaging Center
2018-2025
Early neurological deterioration is associated with poor functional outcomes in stroke patients, but the underlying mechanisms remain unclear. This study aims to understand progression of stroke-related brain damage using a rhesus monkey model ischemic occlusion. Multiparameter MRI was used monitor progressive evolution lesion following stroke. Resting-state MRI, dynamic susceptibility contrast perfusion diffusion tensor imaging, and T1- T2-weighted scans were acquired prior surgery at 4–6...
Background: The oxygen extraction fraction (OEF) indicates the brain’s consumption and can be estimated by using quantitative susceptibility mapping (QSM) MRI technique. Recent studies have suggested that OEF alteration following stroke is associated with viability of at-risk tissue. In present study, temporal evolution in monkey brain during acute was investigated QSM. Methods: Ischemic induced adult rhesus monkeys (n = 8) permanent middle cerebral artery occlusion (pMCAO) an interventional...
Abstract To investigate the effects of neonatal hippocampal lesions on microstructural integrity corpus callosum (CC) in adulthood, macaque monkeys ( n = 5) with bilateral neurotoxic lesion (Neo‐Hibo) and sham‐operated controls (Neo‐C, were scanned using magnetic resonance diffusion tensor imaging (DTI) technique at 8–10 years old. CC was segmented into seven regionsgrouped anterior (rostrum, genu, rostral body midbody) posterior (posterior midbody, isthmus splenium) for data analysis....
Somatosensory deficits are frequently seen in acute stroke patients and may recover over time affect functional outcome. However, the underlying mechanism of function recovery remains poorly understood. In present study, progressive alteration secondary somatosensory cortex (S2) its relationship with regional perfusion neurological outcome were examined using a monkey model stroke.Rhesus monkeys (n = 4) induced permanent middle cerebral artery occlusion (pMCAo). Resting-state MRI, dynamic...
Investigation of stroke lesion has mostly focused on grey matter (GM) in previous studies and white (WM) degeneration during acute is understudied. In the present study, monkeys were utilized to investigate alterations GM WM brain following ischemic occlusion using diffusion tensor imaging (DTI).
Somatosensory deficits are seen in most stroke patients and can improve during recovery from as reported previously. However, the underlining mechanism of remains poorly understood. The nonhuman primate (NHP) model has demonstrated similar functional connectivity evolution secondary somatosensory cortex (S2) NHPs is recognized a direct extrapolation human. In present study, progressive function alteration S2 its relationship with cerebral blood flow (CBF) T2 changes monkey brain acute were...
The corticospinal tract (CST) is a major for motor function. It can be impaired by stroke. Its degeneration associated with stroke outcome. Diffusion tensor imaging (DTI) tractography plays an important role in assessing fiber bundle integrity. However, it limited detecting crossing fibers the brain. angular resolution of intra-voxel structure (CFARI) algorithm shows potential to resolve complex objective present study was improve delineation CST pathways monkey brains scanned conventional DTI.
Non-human primates (NHPs) are the closest living relatives of human and play a critical role in investigating effects maternal viral infection consumption medicines, drugs, alcohol on fetal development. With advance contemporary fast MRI techniques with parallel imaging, is becoming robust tool increasingly used clinical practice preclinical studies to examine congenital abnormalities including placental dysfunction, heart disease (CHD), brain non-invasively. Because NHPs usually scanned...